Enabling the formation of native mAb, Fab′ and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs)

Autor: Fabien Thoreau, Léa N. C. Rochet, James R. Baker, Vijay Chudasama

Publikováno v: Chemical Science. 14:3752-3762

Using a bis-pyridazinedione-based disulfide rebridging agent, we enable the formation of various mAb, Fab′ and Fc conjugates with the ability to tune payload loading on each construct.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2f2b182af1caa106e9e50c88ca22c9f
https://doi.org/10.1039/d2sc06318b

Modular chemical construction of IgG-like mono- and bispecific synthetic antibodies (SynAbs)

Autor: Fabien Thoreau, Peter A. Szijj, Michelle K. Greene, Léa N. C. Rochet, Ioanna A. Thanasi, Jaine K. Blayney, Antoine Maruani, James R. Baker, Christopher J. Scott, Vijay Chudasama

Publikováno v: Thoreau, F, Szijj, P A, Greene, M K, Rochet, L N C, Thanasi, I A, Blayney, J K, Maruani, A, Baker, J R, Scott, C J & Chudasama, V 2023, ' Modular chemical construction of IgG-like mono-and bispecific synthetic antibodies (SynAbs) ', ACS Central Science, vol. 9, no. 3, pp. 476-487 . https://doi.org/10.1021/acscentsci.2c01437

In recent years there has been rising interest in the field of protein–protein conjugation, especially related to bispecific antibodies (bsAbs) and their therapeutic applications. These constructs contain two paratopes capable of binding two distin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c54408a605bd6acd6895ca5b37f529f0
https://pure.qub.ac.uk/en/publications/5f277b29-755b-45e5-9f63-7465bbb31441

Enabling the next steps in cancer immunotherapy: from antibody-based bispecifics to multispecifics, with an evolving role for bioconjugation chemistry

Autor: Vijay Chudasama, Fabien Thoreau

Publikováno v: RSC Chemical Biology. 3:140-169

In the past two decades, immunotherapy has established itself as one of the leading strategies for cancer treatment, as illustrated by the exponentially growing number of related clinical trials. This trend was, in part, prompted by the clinical succ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0038b8ffd349fecaf4ae9c0bbcac6b
https://doi.org/10.1039/d1cb00082a

Synthesis and Biological Characterization of Monomeric and Tetrameric RGD-Cryptophycin Conjugates

Autor: Fabien Thoreau, Jean-Luc Coll, Eduard Figueras, Didier Boturyn, Adina Borbély, Malika Kadri, Norbert Sewald

Publikováno v: Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2020, 26 (12), pp.2602-2605. ⟨10.1002/chem.201905437⟩

The effective delivery of cytotoxic agents to tumor cells is a key challenge in anticancer therapy. Multivalent integrinspecific ligands are considered a promising tool to increase the binding affinity, selectivity, and internalization efficiency of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f75274b01f10e85ac3bb12a5ae06ce
https://pubmed.ncbi.nlm.nih.gov/31943410

Design of RGD–ATWLPPR peptide conjugates for the dual targeting of α V β 3 integrin and neuropilin-1

Autor: Didier Boturyn, Fabien Thoreau, Jean-Luc Coll, Laetitia Vanwonterghem, Maxime Henry

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (22), pp.4101-4107. ⟨10.1039/c8ob00669e⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (22), pp.4101-4107. ⟨10.1039/C8OB00669E⟩

Targeting the tumour microenvironment is a promising strategy to detect and/or treat cancer. The design of selective compounds that co-target several receptors frequently overexpressed in solid tumours may allow a reliable and selective detection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a220dae0c86cc83c32cdfebc20f89fa
https://hal.archives-ouvertes.fr/hal-01846985