Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Fabien, Pierrel"'
Autor:
Sarah Charital, Serena Shunmugam, Sheena Dass, Anna Maria Alazzi, Christophe-Sébastien Arnold, Nicholas J. Katris, Samuel Duley, Nyamekye A. Quansah, Fabien Pierrel, Jérôme Govin, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTApicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have major health and economic burdens. These unicellular pathogens are obligate intracellular parasites that heavily depend on lipid metabolism for the surviva
Externí odkaz:
https://doaj.org/article/9417f62639aa4f78aae0a9672dc9d200
Autor:
Jutta Diessl, Jens Berndtsson, Filomena Broeskamp, Lukas Habernig, Verena Kohler, Carmela Vazquez-Calvo, Arpita Nandy, Carlotta Peselj, Sofia Drobysheva, Ludovic Pelosi, F.-Nora Vögtle, Fabien Pierrel, Martin Ott, Sabrina Büttner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis
Externí odkaz:
https://doaj.org/article/4dc9625ee56c416c8681a2d756ae7db0
Autor:
Rodrigo Arias-Cartin, Katayoun Kazemzadeh Ferizhendi, Emmanuel Séchet, Ludovic Pelosi, Corinne Loeuillet, Fabien Pierrel, Frédéric Barras, Emmanuelle Bouveret
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Isoprenoid quinones are essential for cellular physiology. They act as electron and proton shuttles in respiratory chains and various biological processes. Escherichia coli and many α-, β-, and γ-proteobacteria possess two types of isopre
Externí odkaz:
https://doaj.org/article/69a2da8600964046bbbe167e8ee71fb6
Autor:
Sheena Dass, Serena Shunmugam, Laurence Berry, Christophe-Sebastien Arnold, Nicholas J. Katris, Samuel Duley, Fabien Pierrel, Marie-France Cesbron-Delauw, Yoshiki Yamaryo-Botté, Cyrille Y. Botté
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Apicomplexa generate essential lipids as combination of host fatty acids and de novo synthesized within the apicoplast. Here, the authors identify a phosphatidic acid phosphatase in Toxoplasma gondii, TgLIPIN, as central for controlled lipid synthesi
Externí odkaz:
https://doaj.org/article/226664588bd840de98c6c9d52b6e4025
Autor:
Romain Launay, Elin Teppa, Carla Martins, Sophie S. Abby, Fabien Pierrel, Isabelle André, Jérémy Esque
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10323 (2022)
Ubiquinone (UQ) is a polyisoprenoid lipid found in the membranes of bacteria and eukaryotes. UQ has important roles, notably in respiratory metabolisms which sustain cellular bioenergetics. Most steps of UQ biosynthesis take place in the cytosol of E
Externí odkaz:
https://doaj.org/article/02aeb8cbdcab45bc8a235001ec6858f1
Publikováno v:
Metabolites, Vol 12, Iss 5, p 428 (2022)
Coenzyme Q10 (CoQ10) is a lipid-soluble compound with important physiological functions and is sought after in the food and cosmetic industries owing to its antioxidant properties. In our previous proof of concept, we engineered for CoQ10 biosynthesi
Externí odkaz:
https://doaj.org/article/600a26b3c89d4d3889ecb888ac3ddd43
Autor:
Nathalie Sturm, Morgane Roger-Margueritat, Fabien Pierrel, Philippe Lehours, Muriel Genevay, Bertrand Huard
Publikováno v:
Journal of Leukocyte Biology. 113:376-382
Eosinophils may reside in the lower intestine to play several homeostatic functions. Regulation of IgA+ plasma-cell (PC) homeostasis is one of these functions. Here, we assessed regulation of expression for a proliferation-inducing ligand (APRIL), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b316f832af0c857c3903157cc116be
https://doi.org/10.1093/jleuko/qiad014
https://doi.org/10.1093/jleuko/qiad014
Publikováno v:
MicrobiologyOpen, Vol 9, Iss 8, Pp n/a-n/a (2020)
Abstract Antibiotic‐tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive. Controversies revolve around the relative contribution o
Externí odkaz:
https://doaj.org/article/e728ff20f9c94ec18d7672cb78382025
Autor:
Vinzent Schulz, Somsuvro Basu, Sven-A. Freibert, Holger Webert, Linda Boss, Ulrich Mühlenhoff, Fabien Pierrel, Lars-O. Essen, Douglas M. Warui, Squire J. Booker, Oliver Stehling, Roland Lill
Publikováno v:
Nature Chemical Biology. 19:206-217
Ferredoxins comprise a large family of iron-sulfur (Fe-S) proteins that shuttle electrons in diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] ferredoxins, FDX1 (aka adrenodoxin) and FDX2, with known functions in cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1845ac316956605a467f82d2aea00d31
https://doi.org/10.1038/s41589-022-01159-4
https://doi.org/10.1038/s41589-022-01159-4
Autor:
Ludovic Pelosi, Chau-Duy-Tam Vo, Sophie Saphia Abby, Laurent Loiseau, Bérengère Rascalou, Mahmoud Hajj Chehade, Bruno Faivre, Mathieu Goussé, Clothilde Chenal, Nadia Touati, Laurent Binet, David Cornu, Cameron David Fyfe, Marc Fontecave, Frédéric Barras, Murielle Lombard, Fabien Pierrel
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Most bacteria can generate ATP by respiratory metabolism, in which electrons are shuttled from reduced substrates to terminal electron acceptors, via quinone molecules like ubiquinone. Dioxygen (O2) is the terminal electron acceptor of aerob
Externí odkaz:
https://doaj.org/article/423abeece346423189b8b110c50b32a4