Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fabien, Franco"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/92ae81b79f0540e9ae491f37027d2a81
Autor:
Mukul Girotra, Yi-Hsuan Chiang, Melanie Charmoy, Pierpaolo Ginefra, Frederica Schyrr, Fabien Franco, Ping-Chih Ho, Olaia Naveiras, Johan Auwerx, Werner Held, Nicola Vannini
Aging compromises hematopoietic and immune system functions, making elderly individuals especially susceptible to hematopoietic failure, infections and tumor development and thus representing an important medical target for a broad range of diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1c64909d0b58d5a126b73f112fda707
https://doi.org/10.1101/2023.03.30.534925
https://doi.org/10.1101/2023.03.30.534925
Publikováno v:
Nature Metabolism. 2:1001-1012
Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance. However, after prolonged antigen exposure, CD8+ T cells differentiate into a special differentiation sta
Autor:
Haiping Wang, Isabel C. Lopez-Mejia, Mathias Wenes, Bastien Marti, Nina Dumauthioz, Pedro Romero, Wenhui Li, Benjamin O. Tschumi, Alena Donda, Lluis Fajas, Ping-Chih Ho, Fabien Franco, Lianjun Zhang
Publikováno v:
Cellular and Molecular Immunology
Cellular & molecular immunology, vol. 18, no. 7, pp. 1761-1771
Cellular & molecular immunology, vol. 18, no. 7, pp. 1761-1771
Memory CD8 T cells can provide long-term protection against tumors, which depends on their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain cellular fitness. Specifically, memory CD8 T cells engage oxidative phos
Autor:
Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Giusy Di Conza, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt
Publikováno v:
Cell Reports
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8+ T cells activated and differentiated in vitro in physiological medium to resolve these metabolic dynamics. We identify a differential
Autor:
Giusy Di Conza, Fabien Franco, Chin Hsien Tsai, Piergiorgio Percipalle, Hector Gallart-Ayala, Stanley Ching-Cheng Huang, Léa Zaffalon, Julijana Ivanisevic, Zhengtao Xiao, Antoine Jalil, Jason W. Locasale, Maryline Falquet, Xiaoyun Li, Yi Ru Yu, David Masson, Ping-Chih Ho, Lydia N. Raines, Fabio Martinon, Xin Xie
Publikováno v:
Nature immunology, vol. 22, no. 11, pp. 1403-1415
Tumor-associated macrophages (TAMs) display pro-tumorigenic phenotypes for supporting tumor progression in response to microenvironmental cues imposed by tumor and stromal cells. However, the underlying mechanisms by which tumor cells instruct TAM be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed9ac7cc41a01274b4d01ae94535454
https://serval.unil.ch/notice/serval:BIB_38FF542D6B24
https://serval.unil.ch/notice/serval:BIB_38FF542D6B24
Autor:
Mathias Wenes, Alison Jaccard, Tania Wyss, Noelia Maldonado-Pérez, Shao Thing Teoh, Anouk Lepez, Fabrice Renaud, Fabien Franco, Patrice Waridel, Céline Yacoub Maroun, Benjamin Tschumi, Nina Dumauthioz, Lianjun Zhang, Alena Donda, Francisco Martín, Denis Migliorini, Sophia Y. Lunt, Ping-Chih Ho, Pedro Romero
Publikováno v:
Cell metabolism (2022)
Glycolysis, including both lactate fermentation and pyruvate oxidation, orchestrates CD8+T cell differentiation. However, how mitochondrial pyruvate metabolism and uptake controlled by the mitochondrial pyruvate carrier (MPC) impact T cell function a
Autor:
Juan, Fernández-García, Fabien, Franco, Sweta, Parik, Patricia, Altea-Manzano, Antonino Alejandro, Pane, Dorien, Broekaert, Joke, van Elsen, Ines, Vermeire, Tessa, Schalley, Mélanie, Planque, Thomas, van Brussel, Rogier, Schepers, Elodie, Modave, Tobias K, Karakach, Peter, Carmeliet, Diether, Lambrechts, Ping-Chih, Ho, Sarah-Maria, Fendt
Publikováno v:
Cell reports. 41(7)
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8
Autor:
Sarah-Maria Fendt, Peter Carmeliet, Rogier Schepers, Sweta Parik, Antonino Alejandro Pane, Juan Fernández-García, Fabien Franco, Tobias K. Karakach, Ping-Chih Ho, Dorien Broekaert, Joke Van Elsen, Ines Vermeire, Elodie Modave, Thomas Van Brussel, Diether Lambrechts
Cytotoxic T cells dynamically rewire their metabolism during the course of an immune response. While T-cell metabolism has been extensively studied at phenotypic endpoints of activation and differentiation, the underlying dynamics remain largely elus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81551b208900057b3f8feb8cdf0f083
https://doi.org/10.1101/2021.07.27.453976
https://doi.org/10.1101/2021.07.27.453976
Autor:
Yugang Guo, Yuxi Wang, Haiping Wang, Fabien Franco, Hanshuo Yang, Imran Siddiqui, Pedro Romero, Catherine M. Sabatel, Ping-Chih Ho, Bing Feng, Weihua Xiao, Yu-Qing Xie, Weimin Li, Werner Held, Benjamin O. Tschumi, Alessio Bevilacqua, Amphun Chaiboonchoe, Mathias Wenes, Min Gao, Li Tang, Yang Zhao, Xin Xie
Publikováno v:
Nature Immunology
Nature immunology
Nature immunology, vol. 22, no. 6, pp. 746-756
Nature immunology
Nature immunology, vol. 22, no. 6, pp. 746-756
Tang and colleagues show that a half-life-extended IL-10-Fc fusion protein acts directly on terminally exhausted PD1(+)TIM-3(+)CD8(+) T cells to enhance their proliferation and effector function by reprogramming the cellular metabolism to oxidative p