Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Fabien, Delahaye"'
Autor:
Raquel Furtado, Mahinder Paul, Jinghang Zhang, Joowhan Sung, Paul Karell, Ryung S. Kim, Sophie Caillat-Zucman, Li Liang, Philip Felgner, Andy Bauleni, Syze Gama, Andrea Buchwald, Terrie Taylor, Karl Seydel, Miriam Laufer, Fabien Delahaye, Johanna P. Daily, Grégoire Lauvau
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Clinical immunity against Plasmodium falciparum infection develops in residents of malaria endemic regions, manifesting in reduced clinical symptoms during infection and in protection against severe disease but the mechanisms are not fully u
Externí odkaz:
https://doaj.org/article/8d8983c6bafb42b98c6123c872ef74b1
Autor:
William Casazza, Amy M. Inkster, Giulia F. Del Gobbo, Victor Yuan, Fabien Delahaye, Carmen Marsit, Yongjin P. Park, Wendy P. Robinson, Sara Mostafavi, Jessica K. Dennis
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109047- (2024)
Summary: Molecular quantitative trait loci (QTLs) allow us to understand the biology captured in genome-wide association studies (GWASs). The placenta regulates fetal development and shows sex differences in DNA methylation. We therefore hypothesized
Externí odkaz:
https://doaj.org/article/220ea8500dd1436fa1eeef520eddff9d
Autor:
Franck Auge, Matteo Cesaroni, Angelique Biancotto, Angela Virone-Oddos, Angela Hadjipanayis, Donald Jackson, Galina Boldina, Manoel Nunes, Karine Berthelot, Wilson Dos-Santos-Bele, Fabien Delahaye
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5afac666831c4e6485430eed620be1e5
Autor:
Thibaut Gauvrit, Hamza Benderradji, Alexandre Pelletier, Soulaimane Aboulouard, Emilie Faivre, Kévin Carvalho, Aude Deleau, Emmanuelle Vallez, Agathe Launay, Anna Bogdanova, Mélanie Besegher, Stéphanie Le Gras, Anne Tailleux, Michel Salzet, Luc Buée, Fabien Delahaye, David Blum, Didier Vieau
Publikováno v:
Nutrients, Vol 15, Iss 21, p 4691 (2023)
Early-life exposure to high-fat diets (HF) can program metabolic and cognitive alterations in adult offspring. Although the hippocampus plays a crucial role in memory and metabolic homeostasis, few studies have reported the impact of maternal HF on t
Externí odkaz:
https://doaj.org/article/cdf71de6faea41f1bf108b58721ec789
Autor:
Ana Raquel Melo de Farias, Alexandre Pelletier, Lukas Cruz Carvalho Iohan, Orthis Saha, Amélie Bonnefond, Philippe Amouyel, Fabien Delahaye, Jean-Charles Lambert, Marcos R. Costa
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2564 (2023)
Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, characterized by the presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, synapse loss and neurodegeneration in the brain. The amyloid c
Externí odkaz:
https://doaj.org/article/ddfe357a5c8c476c8210243386f1932f
Autor:
Shu Shien Chin, Erik Guillen, Laurent Chorro, Sooraj Achar, Karina Ng, Susanne Oberle, Francesca Alfei, Dietmar Zehn, Grégoire Altan-Bonnet, Fabien Delahaye, Grégoire Lauvau
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The strength and duration of interleukin-2 (IL-2) signals is known to regulate T cell memory. Here the authors show that T cell receptor signalling strength controls the requirement for IL-2 signals to form CD8+ T cell memory with high functional act
Externí odkaz:
https://doaj.org/article/be0c9487ecc8454f9c2bdb6ecbd69bd9
Autor:
Erwan Lambert, Orthis Saha, Bruna Soares Landeira, Ana Raquel Melo de Farias, Xavier Hermant, Arnaud Carrier, Alexandre Pelletier, Johanna Gadaut, Lindsay Davoine, Cloé Dupont, Philippe Amouyel, Amélie Bonnefond, Frank Lafont, Farida Abdelfettah, Patrik Verstreken, Julien Chapuis, Nicolas Barois, Fabien Delahaye, Bart Dermaut, Jean-Charles Lambert, Marcos R. Costa, Pierre Dourlen
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-23 (2022)
Abstract The Bridging Integrator 1 (BIN1) gene is a major susceptibility gene for Alzheimer’s disease (AD). Deciphering its pathophysiological role is challenging due to its numerous isoforms. Here we observed in Drosophila that human BIN1 isoform1
Externí odkaz:
https://doaj.org/article/5a00e9ef0aa64aa8b839b112c52f6f26
Autor:
Alexandre Pelletier, Arnaud Carrier, Yongmei Zhao, Mickaël Canouil, Mehdi Derhourhi, Emmanuelle Durand, Lionel Berberian-Ferrato, John Greally, Francine Hughes, Philippe Froguel, Amélie Bonnefond, Fabien Delahaye
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7323 (2022)
Excessive fetal growth is associated with DNA methylation alterations in human hematopoietic stem and progenitor cells (HSPC), but their functional impact remains elusive. We implemented an integrative analysis combining single-cell epigenomics, sing
Externí odkaz:
https://doaj.org/article/a2b06bb457d84a89a152df63f1a64cf1
Autor:
Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the benef
Externí odkaz:
https://doaj.org/article/6c2da7569db9463080f4475bda1b2e80
Autor:
Fabien Delahaye, Catherine Do, Yu Kong, Remi Ashkar, Martha Salas, Ben Tycko, Ronald Wapner, Francine Hughes
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008118 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1007785.].
Externí odkaz:
https://doaj.org/article/983ddae95212416bb8f60fb451412613