Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

Autor: Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F. Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gámbaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M. Romero-Vivas, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Johan Neyts, Laurent Nguyen, Suzanne J. F. Kaptein, Louis Lambrechts

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Here, the authors compare seven low passage Zika virus (ZIKV) strains representing the recently circulating viral genetic diversity of African and Asian strains and find that African ZIKV strains have higher transmissibility in mosquitoes and higher

Externí odkaz: https://doaj.org/article/c48f91d15fcb42c39e43fb6ac7859613

Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone

Autor: Franck Touret, Magali Gilles, Raphaelle Klitting, Fabien Aubry, Xavier de Lamballerie, Antoine Nougairède

Publikováno v: Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-12 (2018)

Abstract Zika virus (ZIKV) has recently become dispersed throughout the tropics and sub-tropics, causing epidemics associated with congenital disease and neurological complications. There is currently no commercial vaccine for ZIKV. In this study, we

Externí odkaz: https://doaj.org/article/d2ca378db1b24da992f877fe694de2d0

Haiku: New paradigm for the reverse genetics of emerging RNA viruses.

Autor: Thérèse Atieh, Miriam Diala El Ayoubi, Fabien Aubry, Stéphane Priet, Xavier de Lamballerie, Antoine Nougairède

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0193069 (2018)

Reverse genetics is key technology for producing wild-type and genetically modified viruses. The ISA (Infectious Subgenomic Amplicons) method is a recent versatile and user-friendly reverse genetics method to rescue RNA viruses. The main constraint o

Externí odkaz: https://doaj.org/article/0ef5137f76b94f15bc5bd0cf03be80ad

Attenuation of tick-borne encephalitis virus using large-scale random codon re-encoding.

Autor: Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie

Publikováno v: PLoS Pathogens, Vol 11, Iss 3, p e1004738 (2015)

Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febri

Externí odkaz: https://doaj.org/article/53918eccd20b4bb19c54b8807ad64071

Potential role of vector-mediated natural selection in dengue virus genotype/lineage replacements in two epidemiologically contrasted settings

Autor: Sebastian Lequime, Saraden In, Thavry Hoem, Louis Lambrechts, Nicolas Pocquet, Veasna Duong, Myrielle Dupont-Rouzeyrol, Marine Minier, Valérie Burtet-Sarramegna, Tey Putita Ou, Fabien Aubry, Sébastien Boyer, Olivia O’Connor, Sylvie Russet, Philippe Dussart, Stéphanie Dabo, Dominique Girault

Publikováno v: Emerging microbes & infections
Emerging microbes & infections, 2021, 10 (1), pp.1346-1357. ⟨10.1080/22221751.2021.1944789⟩
Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2021, pp.1-33. ⟨10.1080/22221751.2021.1944789⟩
Emerging Microbes & Infections
article-version (VoR) Version of Record

International audience; Dengue virus (DENV) evolutionary dynamics are characterized by frequent DENV genotype/lineage replacements, potentially associated with changes in disease severity and human immunity. New Caledonia (NC) and Cambodia, two contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edd1dd4cf321d07620dacbc6d4e2b58
https://hal-riip.archives-ouvertes.fr/pasteur-03265221