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Polymorphic Variants in NR1I3 and UGT2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case-Control Study

Autor: Arbitrio, Mariamena, Scionti, Francesca, Altomare, Emanuela, Di Martino, Maria Teresa, Agapito, Giuseppe, Galeano, Teresa, Staropoli, Nicoletta, Iuliano, Eleonora, Grillone, Francesco, Fabiani, Fernanda, Caracciolo, Daniele, Cannataro, Mario, Arpino, Grazia, Santini, Daniele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro

Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important interindividual variability. Genetic polymorphisms in absorption, distribution, metabolism, and excretion (ADME) genes may account for variability in drug efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::7e242f1aef0c546a2f84947c3a0eca33
http://hdl.handle.net/11588/890670

Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study

Autor: Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2, Tagliaferri Pierosandro (2

Publikováno v: Clinical pharmacology and therapeutics (2019). doi:10.1002/cpt.1391
info:cnr-pdr/source/autori:Arbitrio Mariamena (1), Scionti Francesca (2), Altomare Emanuela (2), Di Martino Maria Teresa (2), Agapito Giuseppe (3), Galeano Teresa (2), Staropoli Nicoletta (4), Iuliano Eleonora(2), Grillone rancescaF (4), Fabiani Fernanda (5), Caracciolo Daniele (2), Cannataro Mario (3), Arpino Grazia (6), Santini Daniele (7), Tassone Pierfrancesco (2,3), Tagliaferri Pierosandro (2,3)/titolo:Polymorphic variants in NR1I3 and UGT2B7 predict taxane neurotoxicity and have prognostic relevance in breast cancer patients: a case-control study/doi:10.1002%2Fcpt.1391/rivista:Clinical pharmacology and therapeutics/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume

Taxane-related peripheral neuropathy (TrPN) is a dose-limiting toxicity with important inter-individual variability. Genetic polymorphisms in ADME genes may account for variability in drug efficacy and/or toxicity. By the use of Affymetrix DMETTM mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::d8a7c37c277d69dd8ee4c57f8162802b
https://publications.cnr.it/doc/399806

Multiple Genetic Alterations within the PI3K Pathway Are Responsible for AKT Activation in Patients with Ovarian Carcinoma

Autor: De Marco, Carmela, Rinaldo, Nicola, Bruni, Paola, Malzoni, Carmine, Zullo, Fulvio, Fabiani, Fernanda, Losito, Simona, Scrima, Marianna, Marino, Federica Zito, Quintiero, Alfina, Agosti, Valter, Viglietto, Giuseppe, ZITO MARINO, Federica, FRANCO, Renato

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55362 (2013)
PLoS ONE

The phosphatidylinositol 3-kinase (PI3K)/AKT pathway is activated in multiple cancers including ovarian carcinoma (OC). However, the relative contribution of the single components within the PI3K pathway to AKT activation in OC is still unclear. We e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb222d78195639509c2c393a1a329dd
http://hdl.handle.net/11591/334765