Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Fabiana I.A.L. Layng"'
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
An inhibitor of the pleckstrin homology domain of CNK1 selectively blocks the growth of mutant KRAS cells and tumors Supplemental Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4049decc5165ea5a5548638457e6315
https://doi.org/10.1158/0008-5472.22421073
https://doi.org/10.1158/0008-5472.22421073
Autor:
Garth Powis, Lynn Kirkpatrick, Robert C. Liddington, Laurie A. Bankston, Ricardo G. Correa, Fabiana I.A.L. Layng, Lei Du-Cuny, Robert Lemos, Shuxing Zhang, Emmanuelle J. Meuillet, Zamal Ahmed, Michael Scott, Geoffrey Grandjean, Nathan T. Ihle, Marco Maruggi, Roisin Puentes, Martin Indarte
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570ccd2ee8215290557b6c0ec2d39371
https://doi.org/10.1158/0008-5472.c.6510828.v1
https://doi.org/10.1158/0008-5472.c.6510828.v1
Autor:
Kristiina Vuori, Darren Finlay, Animesh Ray, Masanobu Komatsu, Anupama Sahoo, Ranjan J. Perera, John Marchica, Piyush Joshi, Bongyong Lee, Petrus R. de Jong, Fabiana I.A.L. Layng, Junko Sawada, Joseph Mazar, Sanjay Sahoo
Publikováno v:
J Invest Dermatol
MicroRNAs (miRs) are important posttranscriptional regulators of cell fate in both normal and disease states. miR-211 has previously been shown to be a direct regulator of metabolism in BRAFV600E-mutant melanoma cells in vitro. Here, we report that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96739f14608179f84bd33282f6522d0a
https://doi.org/10.1016/j.jid.2020.06.038
https://doi.org/10.1016/j.jid.2020.06.038
Autor:
Allison S. Limpert, Lena M. Berger, Stefan Knapp, Lester J. Lambert, Nicholas D. P. Cosford, Fabiana I.A.L. Layng, Apirat Chaikuad, Cunxiang Yuan, Jing Dong, Li Wang, Maria Celeridad, Yi Peng, Douglas J. Sheffler, Nicole Bata, Guoxiong Liu, Nicole A Bakas
Publikováno v:
J Med Chem
Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key components of the Hippo signaling pathway, which regulates cell proliferation and death and provides a potential therapeutic target for acute myeloid leukemia (AML). Herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc05bd607eb905af295851148fa0764
https://europepmc.org/articles/PMC10149138/
https://europepmc.org/articles/PMC10149138/
Autor:
Francesca M. Marassi, Martin Indarte, Roisin Puentes, Hei-Cheul Jeung, Alexander E. Aleshin, Laurie A. Bankston, Garth Powis, Ignacio I. Wistuba, Fabiana I.A.L. Layng, Shuxing Zhang, Ricardo G. Correa, Robert C. Liddington, Zamal Ahmed, Emmanuelle J. Meuillet, Yong Yao, Daniela G. Duenas, Lynn Kirkpatrick
Publikováno v:
Exp Cell Res
Plekha7 (Pleckstrin homology [PH] domain containing, family A member 7) regulates the assembly of proteins of the cytoplasmic apical zonula adherens junction (AJ), thus ensuring cell-cell adhesion and tight-junction barrier integrity. Little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e929eb1613fa0052fdd02673a433457c
https://europepmc.org/articles/PMC8925131/
https://europepmc.org/articles/PMC8925131/
Autor:
Ricardo G. Correa, Nathan T. Ihle, Laurie A. Bankston, Robert Lemos, Lynn Kirkpatrick, Michael J. Scott, Shuxing Zhang, Robert C. Liddington, Martin Indarte, Fabiana I.A.L. Layng, Garth Powis, Geoffrey Grandjean, Zamal Ahmed, Lei Du-Cuny, Emmanuelle J. Meuillet, Roisin Puentes, Marco Maruggi
Publikováno v:
Cancer Res
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain-containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c4b1cc628c0b53bf009b240b2162a1
https://pubmed.ncbi.nlm.nih.gov/31040156
https://pubmed.ncbi.nlm.nih.gov/31040156
Autor:
Junko Sawada, Kristiina Vuori, Animesh Ray, Bongyong Lee, Fabiana I.A.L. Layng, Joseph Mazar, Anupama Sahoo, Sanjay Sahoo, Garth Powis, Piyush Joshi, Petrus R. de Jong, Ranajan J. Perera, John Marchica, Darren Finlay, Masanobu Komatsu
The microRNA MIR211 is an important regulator of melanoma tumor cell behavior. Previous studies suggested that in certain tumors, MIR211 acted as a tumor suppressor while in others it behaved as an oncogenic regulator. When MIR211 is expressed in BRA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22915368240920e57cc485a7fe8d9051
Autor:
Fabiana I.A.L. Layng, Marco Maruggi, Petrus R. de Jong, Monica Sevilla, Brian P. James, Ferran Soldevilla, Bas J. G. Baaten, Mei Yee Koh, Robert Lemos, Garth Powis, Guillermina Garcia
Publikováno v:
Cancer Res
Cancer cells respond to hypoxia by upregulating the hypoxia-inducible factor 1α (HIF1A) transcription factor, which drives survival mechanisms that include metabolic adaptation and induction of angiogenesis by VEGF. Pancreatic tumors are poorly vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06686c77e18d1532d085ef87f6204926
https://pubmed.ncbi.nlm.nih.gov/31585939
https://pubmed.ncbi.nlm.nih.gov/31585939
Autor:
Ricardo G. Correa, Roisin Puentes, Nathan T. Ihle, Fabiana I.A.L. Layng, Robert Lemos, Mike Scott, Marco Maruggi, Lei Du-Cuny, Garth Powis, Laurie A. Bankston, Robert C. Liddington, Zamal Ahmed, Martin Indarte, Lynn Kirkpatrick, Emmanuelle J. Meuillet, Geoffrey Grandjean, Shuxing Zang
Publikováno v:
Cancer research. 79(12)
Cnk1 (connector enhancer of kinase suppressor of Ras 1) is a pleckstrin homology (PH) domain–containing scaffold protein that increases the efficiency of Ras signaling pathways, imparting efficiency and specificity to the response of cell prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf247d096d80bb6b6446e9263018847
https://pubmed.ncbi.nlm.nih.gov/31615811
https://pubmed.ncbi.nlm.nih.gov/31615811
Autor:
Piyush Joshi, Animesh Ray, Bongyong Lee, Anupama Sahoo, Masanobu Komatsu, Fabiana I.A.L. Layng, Kristiina Vuori, Joseph Mazar, Ranjan J Perera, John Marchica, Darren Finlay, Junko Sawada, Dimitrios G. Zisoulis, Garth Powis, Petrus R. de Jong, Sanjay Sahoo
Publikováno v:
Cancer Research. 79:3550-3550
The microRNA miR-211 is an established participant in melanomagenesis, but controversy exists as to whether it acts as a bone fide tumor suppressor or oncogene. Here we ectopically expressed miR-211 in the BRAF v600E-mutant A375 melanoma cell line an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4b5aa0beaa818ed88497b81fdaf70f0
https://doi.org/10.1158/1538-7445.am2019-3550
https://doi.org/10.1158/1538-7445.am2019-3550