Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Fabiana Perna"'
Autor:
Maryam Ghashghaei, Yilin Liu, James Ettles, Giuseppe Bombaci, Niveditha Ramkumar, Zongmin Liu, Leo Escano, Sandra Spencer Miko, Yerin Kim, Joseph A. Waldron, Kim Do, Kyle MacPherson, Katie A. Yuen, Thilelli Taibi, Marty Yue, Aaremish Arsalan, Zhen Jin, Glenn Edin, Aly Karsan, Gregg B. Morin, Florian Kuchenbauer, Fabiana Perna, Martin Bushell, Ly P. Vu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Protein synthesis is frequently deregulated during tumorigenesis. However, the precise contexts of selective translational control and the regulators of such mechanisms in cancer is poorly understood. Here, we uncovered CNOT3, a subunit of t
Externí odkaz:
https://doaj.org/article/70b7701b4c0b40d88cc303cdcb9178b8
Autor:
Maryam Ghashghaei, Yilin Liu, James Ettles, Giuseppe Bombaci, Niveditha Ramkumar, Zongmin Liu, Leo Escano, Sandra Spencer Miko, Yerin Kim, Joseph A. Waldron, Kim Do, Kyle MacPherson, Katie A. Yuen, Thilelli Taibi, Marty Yue, Aaremish Arsalan, Zhen Jin, Glenn Edin, Aly Karsan, Gregg B. Morin, Florian Kuchenbauer, Fabiana Perna, Martin Bushell, Ly P. Vu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0f59f076c7fc4285a49794e5de178a16
Autor:
Silvia Marino, Daniela N. Petrusca, Ryan T. Bishop, Judith L. Anderson, Hayley M. Sabol, Cody Ashby, Justin H. Layer, Annamaria Cesarano, Utpal P. Davé, Fabiana Perna, Jesus Delgado-Calle, John M. Chirgwin, G. David Roodman
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
Multiple myeloma (MM) is a malignancy of plasma cells whose antibody secretion creates proteotoxic stress relieved by the N-end rule pathway, a proteolytic system that degrades N-arginylated proteins in the proteasome. When the proteasome is inhibite
Externí odkaz:
https://doaj.org/article/9399ee6ec7fd4afdb54ee2c23dc3ce56
Autor:
Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, Devin Bready, Hayley Donaldson, Christopher Lawson, Cathryn Lapierre, Aryeh Korman, Tori Rodrick, Enze Liu, Joshua D. Frenster, Gabriele Stephan, Jordan Wilcox, Alexis D. Corrado, Julia Cai, Rebecca Ronnen, Shuai Wang, Sara Haddock, Jonathan Sabio Ortiz, Orin Mishkit, Alireza Khodadadi-Jamayran, Aris Tsirigos, David Fenyö, David Zagzag, Julia Drube, Carsten Hoffmann, Fabiana Perna, Drew R. Jones, Richard Possemato, Akiko Koide, Shohei Koide, Christopher Y. Park, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113374- (2023)
Summary: Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as treatment targets. Here, we show that CD97 (ADGRE5) is the most promi
Externí odkaz:
https://doaj.org/article/e954f101e34e4454841a124bf6a6e405
Corrigendum: Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma
Autor:
Hong Phuong Nguyen, Anh Quynh Le, Enze Liu, Annamaria Cesarano, Francesco DiMeo, Fabiana Perna, Reuben Kapur, Brian A. Walker, Ngoc Tung Tran
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/ba67b86054da46258eada6bd445a2061
Autor:
Hong Phuong Nguyen, Anh Quynh Le, Enze Liu, Annamaria Cesarano, Francesco DiMeo, Fabiana Perna, Reuben Kapur, Brian A. Walker, Ngoc Tung Tran
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Multiple myeloma (MM) is a devastating plasma cell malignancy characterized by the expansion of aberrant monoclonal plasma cells in the bone marrow, leading to severe clinical manifestations and poor prognosis, particularly in relapsed/refractory cas
Externí odkaz:
https://doaj.org/article/b9200917b99549e9a2974c8b73d1ad82
Autor:
Lakshmi Reddy Palam, Baskar Ramdas, Katelyn Pickerell, Santhosh Kumar Pasupuleti, Rahul Kanumuri, Annamaria Cesarano, Megan Szymanski, Bryce Selman, Utpal P. Dave, George Sandusky, Fabiana Perna, Sophie Paczesny, Reuben Kapur
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Loss-of-function mutations in the DNA methyltransferase 3A (DNMT3A) are seen in a large number of patients with acute myeloid leukemia (AML) with normal cytogenetics and are frequently associated with poor prognosis. DNMT3A mutations are an early pre
Externí odkaz:
https://doaj.org/article/ec0e132ad5ae448a979e9b996e562b3e
Autor:
Christopher Schorr, Fabiana Perna
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Acute Myeloid Leukemia (AML) is an aggressive myeloid malignancy associated with high mortality rates (less than 30% 5-year survival). Despite advances in our understanding of the molecular mechanisms underpinning leukemogenesis, standard-of-care the
Externí odkaz:
https://doaj.org/article/29360531fc714cb1bd13c987c9a554ef
Autor:
Suheil Albert Atallah-Yunes, Michael J. Robertson, Utpal P. Davé, Paola Ghione, Fabiana Perna
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Prognosis for patients with refractory/relapsed (R/R) diffuse large B-cell lymphoma (DLBCL) is poor. Immune-based therapeutic treatments such as CD19 Chimeric Antigen Receptor (CAR) T cell therapies have dramatically changed the treatment landscape f
Externí odkaz:
https://doaj.org/article/6c7256b69a6a4c90871d8fb86e73e022
Autor:
Christopher Schorr, Jorge Forindez, Manuel Espinoza-Gutarra, Rakesh Mehta, Natalie Grover, Fabiana Perna
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8349 (2023)
Chimeric antigen receptor (CAR) T-cell therapy has greatly transformed the treatment and prognosis of B-cell hematological malignancies. As CAR T-cell therapy continues to be more readily adopted and indications increase, the field’s recognition of
Externí odkaz:
https://doaj.org/article/e897862caa594fbe87ee4021a98bd30a