Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Fabiana, Perocchi"'
Autor:
Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Monika S. Brill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies
Externí odkaz:
https://doaj.org/article/ec46b342acf04066b968bee81cb16163
Autor:
Alexandros A. Pittis, Valerie Goh, Alberto Cebrian-Serrano, Jennifer Wettmarshausen, Fabiana Perocchi, Toni Gabaldón
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The mitochondrial calcium uptake system, crucial for cellular processes, evolved in ancient eukaryotes. Here, authors perform a phylogenomic analysis across 1,156 eukaryotes, and show that previously identified animal and fungal genes in this system
Externí odkaz:
https://doaj.org/article/be276a83a522423db2f562d273d11d58
Autor:
Thomas Meul, Korbinian Berschneider, Sabine Schmitt, Christoph H. Mayr, Laura F. Mattner, Herbert B. Schiller, Ayse S. Yazgili, Xinyuan Wang, Christina Lukas, Camille Schlesser, Cornelia Prehn, Jerzy Adamski, Elisabeth Graf, Thomas Schwarzmayr, Fabiana Perocchi, Alexandra Kukat, Aleksandra Trifunovic, Laura Kremer, Holger Prokisch, Bastian Popper, Christine von Toerne, Stefanie M. Hauck, Hans Zischka, Silke Meiners
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108059- (2020)
Summary: The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs. Here, we demonstrate that mitochondrial dysfunction and concomitant metabolic reprogramming of the tric
Externí odkaz:
https://doaj.org/article/777edfb804a34fd7bfeb044873d90981
Autor:
Alexandra Stavsky, Ohad Stoler, Marko Kostic, Tomer Katoshevsky, Essam A. Assali, Ivana Savic, Yael Amitai, Holger Prokisch, Steffen Leiz, Cornelia Daumer-Haas, Ilya Fleidervish, Fabiana Perocchi, Daniel Gitler, Israel Sekler
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/71dbc48b81ff44bf90112ee9c7bd576d
Autor:
Jennifer Wettmarshausen, Valerie Goh, Kai-Ting Huang, Daniela M. Arduino, Utkarsh Tripathi, Anja Leimpek, Yiming Cheng, Alexandros A. Pittis, Toni Gabaldón, Dejana Mokranjac, György Hajnóczky, Fabiana Perocchi
Publikováno v:
Cell Reports, Vol 25, Iss 6, Pp 1425-1435.e7 (2018)
Summary: The mitochondrial calcium uniporter is a highly selective ion channel composed of species- and tissue-specific subunits. However, the functional role of each component still remains unclear. Here, we establish a synthetic biology approach to
Externí odkaz:
https://doaj.org/article/ba54a49daa084585978270d366902706
Autor:
Seiji Kishi, Gabriela Campanholle, Vishal M. Gohil, Fabiana Perocchi, Craig R. Brooks, Ryuji Morizane, Venkata Sabbisetti, Takaharu Ichimura, Vamsi K. Mootha, Joseph V. Bonventre
Publikováno v:
EBioMedicine, Vol 2, Iss 9, Pp 1090-1101 (2015)
Global or local ischemia contributes to the pathogenesis of acute kidney injury (AKI). Currently there are no specific therapies to prevent AKI. Potentiation of glycolytic metabolism and attenuation of mitochondrial respiration may decrease cell inju
Externí odkaz:
https://doaj.org/article/c728f1ea69d94c5695d54c6a5aba4701
Autor:
Tomer Katoshevsky, Fabiana Perocchi, Daniel Gitler, Essam A. Assali, Steffen Leiz, Ohad Stoler, Marko Kostic, Yael Amitai, Ilya A. Fleidervish, Ivana Savic, Israel Sekler, Alexandra Stavsky, Holger Prokisch, Cornelia Daumer-Haas
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Comm. Biol. 4:666 (2021)
Communications Biology
Comm. Biol. 4:666 (2021)
Communications Biology
Calcium dynamics control synaptic transmission. Calcium triggers synaptic vesicle fusion, determines release probability, modulates vesicle recycling, participates in long-term plasticity and regulates cellular metabolism. Mitochondria, the main sour
Autor:
Annika Schneider, Veit Hornung, Melanie Laschinger, Susan Kläger, Norber Hüser, Marcus Brugger, Hans Zischka, Daniel Hartmann, Philippe Schmitt-Kopplin, Marianne K. Janas, Ulrike Protzer, Percy A. Knolle, Dietmar Zehn, Fabiana Perocchi, Kerstin Lohr, Sandra Lampl, Marcus Conrad, Martin Klingenspor, Andreas Pichlmair, Philipp J. Jost, K Manske, Laura E. Sperl, Sainitin Donakonda, Franz Hagn, Hamid Kashkar, Dirk Wohlleber, Bernhard Kuster, Martin Krönke, Sabrina Schreiner, Katja Steiger, Mathias Heikenwalder, Marco Prinz, Jennifer Wettmarshausen, Christoph Borner, Constanze Müller, Lars Zender
Publikováno v:
J. Hepatol. 73, 1347-1359 (2020)
Background & Aims Selective elimination of virus-infected hepatocytes occurs through virus-specific CD8 T cells recognizing peptide-loaded MHC molecules. Herein, we report that virus-infected hepatocytes are also selectively eliminated through a cell
Autor:
Angelika B. Harbauer, J. Tabitha Hees, Simone Wanderoy, Inmaculada Segura, Whitney Gibbs, Yiming Cheng, Martha Ordonez, Zerong Cai, Romain Cartoni, Ghazaleh Ashrafi, Chen Wang, Fabiana Perocchi, Zhigang He, Thomas L. Schwarz
Publikováno v:
Neuron 110, 1516-1531.e9 (2022)
PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa706e9325823230f048bfb2512a6aa
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64542
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=64542
Autor:
Paulina, Sander, Michael, Feng, Maria K, Schweitzer, Fabiola, Wilting, Sophie M, Gutenthaler, Daniela M, Arduino, Sandra, Fischbach, Lisa, Dreizehnter, Alessandra, Moretti, Thomas, Gudermann, Fabiana, Perocchi, Johann, Schredelseker
Publikováno v:
British journal of pharmacologyREFERENCES. 178(22)
Treatment of cardiac arrhythmia remains challenging due to severe side effects of common anti-arrhythmic drugs. We previously demonstrated that mitochondrial CaHerewe screened 727 compounds with a history of use in human clinical trials in a three-st