Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Fabian den Brave"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4618-4625 (2022)
A complex network of molecular chaperones and proteolytic machinery safeguards the proteins which comprise the proteome, from the time they are synthesized on ribosomes to their destruction via proteolysis. Impaired protein quality control results in
Externí odkaz:
https://doaj.org/article/7aeb2908854d499bbf65936f59cbd10d
Autor:
Matías Capella, Imke K. Mandemaker, Lucía Martín Caballero, Fabian den Brave, Boris Pfander, Andreas G. Ladurner, Stefan Jentsch, Sigurd Braun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
rDNA repeats residing in the nucleolus must be released to the nucleoplasm to allow repair by homologous recombination. Here the authors reveal insights into the molecular mechanism proposing that phosphorylation and SUMOylation of the rDNA-tethering
Externí odkaz:
https://doaj.org/article/7c25cbe4fae14af59e6291014ce9f3bc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondria contain two membranes, the outer and inner membrane. The outer membrane fulfills crucial functions for the communication of mitochondria with the cellular environment like exchange of lipids via organelle contact sites, the transport of
Externí odkaz:
https://doaj.org/article/9a8d6a10ecf54c79b54f7c697e4fefbd
Autor:
Fabian den Brave, Lucas V. Cairo, Chandhuru Jagadeesan, Carmen Ruger-Herreros, Axel Mogk, Bernd Bukau, Stefan Jentsch
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the absence of the autophagic machinery, nuclear protein aggrega
Externí odkaz:
https://doaj.org/article/1bce3ea995b94ff6894220e79aaecc63
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mitochondria are essential organelles important for energy production, proliferation, and cell death. Biogenesis, homeostasis, and degradation of this organelle are tightly controlled to match cellular needs and counteract chronic stress conditions.
Externí odkaz:
https://doaj.org/article/b4e10c45d6df4179bdc9091b7de3dc2a
Publikováno v:
Bio-Protocol, Vol 8, Iss 22 (2018)
In this protocol we describe the separation and visualization of ubiquitylated forms of the yeast mitofusin Fzo1 by Western blot. To this aim, we express HA-tagged Fzo1 in Saccharomyces cerevisiae, break the cells to extract a membrane-enriched fract
Externí odkaz:
https://doaj.org/article/e7e2ab053e374e2b855ea6d536c2144a
Publikováno v:
eLife, Vol 7 (2018)
Cdc48/p97, a ubiquitin-selective chaperone, orchestrates the function of E3 ligases and deubiquitylases (DUBs). Here, we identify a new function of Cdc48 in ubiquitin-dependent regulation of mitochondrial dynamics. The DUBs Ubp12 and Ubp2 exert oppos
Externí odkaz:
https://doaj.org/article/091815149a064e6c82ccd4df8c9f26c2
Autor:
Uwe Schulte, Fabian den Brave, Alexander Haupt, Arushi Gupta, Jiyao Song, Catrin S. Müller, Jeannine Engelke, Swadha Mishra, Christoph Mårtensson, Lars Ellenrieder, Chantal Priesnitz, Sebastian P. Straub, Kim Nguyen Doan, Bogusz Kulawiak, Wolfgang Bildl, Heike Rampelt, Nils Wiedemann, Nikolaus Pfanner, Bernd Fakler, Thomas Becker
Publikováno v:
Nature. 614:153-159
Mitochondria have crucial roles in cellular energetics, metabolism, signalling and quality control1–4. They contain around 1,000 different proteins that often assemble into complexes and supercomplexes such as respiratory complexes and preprotein t
Autor:
Jon V. Busto, Hannah Mathar, Conny Steiert, Eva F. Schneider, Sebastian P. Straub, Lars Ellenrieder, Jiyao Song, Sebastian B. Stiller, Philipp Lübbert, Bernard Guiard, Fabian den Brave, Uwe Schulte, Bernd Fakler, Thomas Becker, Nils Wiedemann
SUMMARYThe majority of mitochondrial precursor proteins are imported through the Tom40 β-barrel channel of the translocase of the outer membrane (TOM). The sorting and assembly machinery (SAM) is essential for β-barrel membrane protein insertion in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a2ae70e0b950c1bbab7cca212dee99
https://doi.org/10.1101/2023.02.03.527057
https://doi.org/10.1101/2023.02.03.527057
Autor:
Saskia Rödl, Fabian den Brave, Markus Räschle, Svenja Lenhard, Carina Groh, Hanna Becker, Jannik Zimmermann, Bruce Morgan, Elke Richling, Thomas Becker, Johannes M. Herrmann
Mitochondria are essential organelles that play a key role in cellular energy metabolism. Transitions between glycolytic and respiratory conditions induce considerable adaptations of the cellular proteome. These metabolism-dependent changes are parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d368b806046d2640b4b3d0de6ca8ffd7
https://doi.org/10.1101/2022.04.26.489513
https://doi.org/10.1101/2022.04.26.489513