Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Fabian Zanella"'
Autor:
Cleber A Trujillo, Jason W Adams, Priscilla D Negraes, Cassiano Carromeu, Leon Tejwani, Allan Acab, Ben Tsuda, Charles A Thomas, Neha Sodhi, Katherine M Fichter, Sarah Romero, Fabian Zanella, Terrence J Sejnowski, Henning Ulrich, Alysson R Muotri
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Duplication or deficiency of the X‐linked MECP2 gene reliably produces profound neurodevelopmental impairment. MECP2 mutations are almost universally responsible for Rett syndrome (RTT), and particular mutations and cellular mosaicism of M
Externí odkaz:
https://doaj.org/article/62a5f92686b74314967f1f52b82ce189
Autor:
Grace Woodruff, Naomi Phillips, Cassiano Carromeu, Oivin Guicherit, Alistair White, McCay Johnson, Fabian Zanella, Blake Anson, Timothy Lovenberg, Pascal Bonaventure, Anthony W Harrington
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240991 (2020)
Human induced Pluripotent Stem Cells (iPSCs) are a powerful tool to dissect the biology of complex human cell types such as those of the central nervous system (CNS). However, robust, high-throughput platforms for reliably measuring activity in human
Externí odkaz:
https://doaj.org/article/35b57f2d9c9348399512c9991766b55f
Autor:
Ileana Slavin, Steven Dea, Priyanka Arunkumar, Neha Sodhi, Sandro Montefusco, Jair Siqueira-Neto, Janet Seelke, Mary Anne Lofstrom, Blake Anson, Fabian Zanella, Cassiano Carromeu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1908 (2021)
With increasing global health threats has come an urgent need to rapidly develop and deploy safe and effective therapies. A common practice to fast track clinical adoption of compounds for new indications is to repurpose already approved therapeutics
Externí odkaz:
https://doaj.org/article/e1ea4556e8d64a8390882339fe1a6956
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1823 (2008)
BACKGROUND: Inhibition of Akt signaling is considered one of the most promising therapeutic strategies for many cancers. However, rational target-orientated approaches to cell based drug screens for anti-cancer agents have historically been compromis
Externí odkaz:
https://doaj.org/article/10168327854240408c88e4880d6144be
Abstract 105: Novel Functions For Synaptosomal-associated Protein 29 (snap29) In Cardiac Arrhythmias
Autor:
Farah Sheikh, Fabian Zanella, Jie Wang, Kirk L. Peterson, Vishal Nigam, Yan Liang, Jing Zhang, Yusu Gu, Jason Pellman, Nancy D. Dalton, Robert C. Lyon, Valeria Mezzano
Publikováno v:
Circulation Research. 129
Human genetic studies and mouse models have classically linked mutations/deficiencies in components of the desmosomal cell-cell junction to arrhythmogenic right ventricular cardiomyopathy (ARVC). However, growing evidence points to the importance of
Autor:
Cassiano Carromeu, Melvin M. Scheinman, Kyohei Fujita, Kirk L. Peterson, William H. Bradford, Ioannis Karakikes, Robert C. Lyon, Valeria Mezzano, Alysson R. Muotri, J. Martin, Jason D. Roberts, Fabian Zanella, Farah Sheikh, Jing Zhang, Yusu Gu
Publikováno v:
Circulation Research. 129
Limited efforts have been focused on the interventions which could therapeutically alter arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C), a fatal cardiac disease of the desmosomal (mechanical) cell-cell junction. The desmosome is a
Autor:
Cassiano Carromeu, Yusu Gu, Melvin M. Scheinman, Fabian Zanella, Philip C. Ursell, Kirk Peterson, Valeria Mezzano, Farah Sheikh, Alysson R. Muotri, Jody Carl Martin, Robert Lyon, Jason Roberts, Jing Zhang
Publikováno v:
The FASEB Journal. 35
Autor:
Fabian Zanella, Mary Anne Lofstrom, Janet Seelke, Blake Anson, Sandro Montefusco, Steven Dea, Priyanka Arunkumar, Ileana Slavin, Neha Sodhi, Jair L. Siqueira-Neto, Cassiano Carromeu
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1908, p 1908 (2021)
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1908, p 1908 (2021)
With increasing global health threats has come an urgent need to rapidly develop and deploy safe and effective therapies. A common practice to fast track clinical adoption of compounds for new indications is to repurpose already approved therapeutics
Publikováno v:
Diabetes. 69
Diabetes mellitus (DM) is a prevalent and chronic metabolic disorder that affects more than 300 million patients in the world. One of the major obstacles in DM is the lack of in vitro models that can capture the physiological features of the in vivo
Autor:
Neha Sodhi, Oksana Sirenko, Oivin Guicherit, Grischa Chandy, Carole Crittenden, Sergio Mora-Castilla, Fabian Zanella, Steven Biesmans, Mamta Behl, Sarah Vargas-Hurlston, Frederick M. Parham, Ryan Gordon, Kristen Ryan, Steven Dea, Cassiano Carromeu
Publikováno v:
Toxicological Sciences. 167:58-76
Neurological disorders affect millions of people worldwide and appear to be on the rise. Whereas the reason for this increase remains unknown, environmental factors are a suspected contributor. Hence, there is an urgent need to develop more complex,