Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Fabian V. Filipp"'
Quiescence and aging of melanocyte stem cells and a novel association with programmed death-ligand 1
Autor:
Joseph W. Palmer, Kyrene M. Villavicencio, Misgana Idris, Ian J. Baranyk, Nunaya Polycarp, Alex D. Dawson, Dominique Weddle, William J. Pavan, Fabian V. Filipp, Melissa L. Harris
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110908- (2024)
Summary: Cellular quiescence is a reversible and tightly regulated stem cell function essential for healthy aging. However, the elements that control quiescence during aging remain poorly defined. Using melanocyte stem cells (McSCs), we find that ste
Externí odkaz:
https://doaj.org/article/1a31ec8ff6884852991e7733ad925b6f
Autor:
Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri, Ivana L. de la Serna
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Background Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of cell identity and diffe
Externí odkaz:
https://doaj.org/article/3388d5c1150043a58943b8a9ef32ec3a
Autor:
Richard H. Kimura, Ling Wang, Bin Shen, Li Huo, Willemieke Tummers, Fabian V. Filipp, Haiwei Henry Guo, Thomas Haywood, Lotfi Abou-Elkacem, Lucia Baratto, Frezghi Habte, Rammohan Devulapally, Timothy H. Witney, Yan Cheng, Suhas Tikole, Subhendu Chakraborti, Jay Nix, Christopher A. Bonagura, Negin Hatami, Joshua J. Mooney, Tushar Desai, Scott Turner, Richard S. Gaster, Andrea Otte, Brendan C. Visser, George A. Poultsides, Jeffrey Norton, Walter Park, Mark Stolowitz, Kenneth Lau, Eric Yang, Arutselvan Natarajan, Ohad Ilovich, Shyam Srinivas, Ananth Srinivasan, Ramasamy Paulmurugan, Juergen Willmann, Frederick T. Chin, Zhen Cheng, Andrei Iagaru, Fang Li, Sanjiv S. Gambhir
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.
Externí odkaz:
https://doaj.org/article/029f63b5dea042f582dd348aecf36a8e
Autor:
Neil F. Box, Lionel Larue, Prashiela Manga, Lluis Montoliu, Richard A. Spritz, Fabian V. Filipp
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-6 (2018)
Abstract The International Federation of Pigment Cell Societies (IFPCS) held its XXIII triennial International Pigment Cell Conference (IPCC) in Denver, Colorado in August 2017. The goal of the summit was to provide a venue promoting a vibrant interc
Externí odkaz:
https://doaj.org/article/3a98407a530442f28445dce227e3197a
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions from mouse ESCs using o
Externí odkaz:
https://doaj.org/article/f349aa99471e4090bb4e46cd16334275
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 2, Pp 121-132 (2016)
The epigenetic modifier EZH2 is in the center of a repressive complex controlling differentiation of normal cells. In cancer EZH2 has been implicated in silencing tumor suppressor genes. Its role in melanoma as well as target genes affected by EZH2 a
Externí odkaz:
https://doaj.org/article/704f39f89a894b89a4d5598140a5c899
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 4, Pp 664-673 (2012)
Ursodeoxycholic acid (UDCA, ursodiol) is used to prevent damage to the liver in patients with primary biliary cirrhosis. The drug also prevents the progression of colorectal cancer and the recurrence of high-grade colonic dysplasia. However, the mole
Externí odkaz:
https://doaj.org/article/a1c1550ef295401588af24834665c24c
Autor:
Tupa Basuroy, Megan Dreier, Caitlin Baum, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Ivana L. de la Serna
Publikováno v:
Pigment Cell Melanoma Res. 36, 19-32 (2023)
Lineage-specific differentiation programs are activated by epigenetic changes in chromatin structure. Melanin-producing melanocytes maintain a gene expression program ensuring appropriate enzymatic conversion of metabolites into the pigment, melanin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68a6cc7d1a03fa12b76e28d35f8c92b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66392
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66392
Autor:
Vijayasaradhi Setaluri, Caitlin E. Baum, Ivana L. de la Serna, Brandon Lewis, Thomas M. Blomquist, Tupa Basuroy, Robert J. Trumbly, Archit R. Trivedi, Aanchal Mehrotra, Fabian V. Filipp
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-18 (2020)
Epigenetics Chromatin 13:14 (2020)
Epigenetics & Chromatin
Epigenetics Chromatin 13:14 (2020)
Epigenetics & Chromatin
BackgroundPharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer. Some studies have also implicated BET proteins as regulators of cell identity and differentiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc5d4c65f2e1a773a923abaa01ccad0
http://link.springer.com/article/10.1186/s13072-020-00333-z
http://link.springer.com/article/10.1186/s13072-020-00333-z
Autor:
Fabian V. Filipp
Publikováno v:
Curr. Genet. Med. Rep. 7, 208-213 (2019)
Current genetic medicine reports
Current genetic medicine reports
Purpose of Review We critically evaluate the future potential of machine learning (ML), deep learning (DL), and artificial intelligence (AI) in precision medicine. The goal of this work is to show progress in ML in digital health, to exemplify future
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2a8c8b89c77fd3b4ce0c543e7ead5
https://doi.org/10.1007/s40142-019-00177-4
https://doi.org/10.1007/s40142-019-00177-4