Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Fabian Steinebach"'
Publikováno v:
Current Opinion in Biotechnology. 53:76-84
With the growth of our understanding of biopharmaceutical processes, a transition from classical batch to continuous integrated manufacturing of therapeutic proteins is taking place across laboratory, clinical and commercial scales. Encouraged by reg
Autor:
Fabian Steinebach, Efstratios N. Pistikopoulos, Massimo Morbidelli, Maria M. Papathanasiou, Athanasios Mantalaris
Publikováno v:
Computers & Chemical Engineering. 105:173-184
Process Intensification (PI) has been gaining increasing interest as industrial trends urge a shift towards more eco-efficient processes of significantly decreased operation and capital costs. In this direction we focus on the development of advanced
Publikováno v:
Journal of Chromatography A. 1507:95-103
In this work the relation between physical and chemical resin characteristics and the total amount of adsorbed protein (saturation capacity) for ion-exchange resins is discussed. Eleven different packing materials with a sulfo-functionalization and o
Publikováno v:
Industrial & Engineering Chemistry Research. 56:13482-13489
A procedure for designing the operation parameter space for the twin-column multicolumn countercurrent solvent gradient purification (MCSGP) process for the purification of therapeutic proteins is derived. This is based on the equilibrium theory, whi
Autor:
Efstratios N. Pistikopoulos, Ana L. Quiroga-Campano, Athanasios Mantalaris, Montaña Elviro, Maria M. Papathanasiou, Fabian Steinebach
Publikováno v:
Biotechnology Progress. 33:966-988
Current industrial trends encourage the development of sustainable, environmentally friendly processes with minimal energy and material consumption. In particular, the increasing market demand in biopharmaceutical industry and the tight regulations i
Publikováno v:
Biotechnology and Bioengineering. 114:298-307
Continuous manufacturing is currently being seriously considered in the biopharmaceutical industry as the possible new paradigm for producing therapeutic proteins, due to production cost and product quality related benefits. In this study, a monoclon
Publikováno v:
Biotechnology Journal. 11:1126-1141
The economic advantages of continuous processing of biopharmaceuticals, which include smaller equipment and faster, efficient processes, have increased interest in this technology over the past decade. Continuous processes can also improve quality as
Autor:
Andreas Hierlemann, Jasmin Krismer, Gregor W. Schmidt, Marie R.G. Kopp, Daniel J. Karst, Renato Zenobi, Robert F. Steinhoff, Massimo Morbidelli, Martin Pabst, Fabian Steinebach, Alexander Stettler, Miroslav Soos
Publikováno v:
Methods. 104:33-40
Cell culture process monitoring in monoclonal antibody (mAb) production is essential for efficient process development and process optimization. Currently employed online, at line and offline methods for monitoring productivity as well as process rep
Advanced control strategies for the multicolumn countercurrent solvent gradient purification process
Autor:
Efstratios N. Pistikopoulos, Richard Oberdieck, Massimo Morbidelli, Styliani Avraamidou, Fabian Steinebach, Thomas Mueller-Spaeth, Athanasios Mantalaris, Maria M. Papathanasiou
Publikováno v:
AIChE Journal. 62:2341-2357
The multicolumn countercurrent solvent gradient purification process (MCSGP) is a semicontinuous, chromatographic separation process used in the production of monoclonal antibodies) . The process is characterized by high model complexity and periodic
Publikováno v:
Continuous Biomanufacturing-Innovative Technologies and Methods ISBN: 9783527699902
Continuous Biomanufacturing - Innovative Technologies and Methods
Continuous Biomanufacturing - Innovative Technologies and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecfdfedf135b8cc41c20788543da7e7f
https://doi.org/10.1002/9783527699902.ch16
https://doi.org/10.1002/9783527699902.ch16