Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fabian Stavenuiter"'
Autor:
Peter Thygesen, A. Henriksen, Haisun Zhu, Mette B. Hermit, Laust Bruun Johnsen, Per Jr Greisen, Søren Lund, Henrik Rahbek-Nielsen, Stine Kjellev, Kasper Lamberth, Henrik Østergaard, Eva Johansson, Thomas Lindebo Holm, Jais Rose Bjelke, Prafull S. Gandhi, Carsten Dan Ley, Daniel Elenius Madsen, Nikolai Lorenzen, Lisbeth Moreau Andersen, Zhiru Yang, Gustav Røder, Jacob Lund, Mette Loftager, Bjarne Gram Hansen, Amalie Carnbring Bonde, Rong Zhou, Ida Hilden, Thomas Egebjerg, Karina Thorn, Morten Grønbech Rasch, Xun Li, Fabian Stavenuiter
Publikováno v:
Blood
Østergaard and colleagues report the development of a potent bispecific antibody, Mim8, which binds both activated factor IX and factor X, mimicking the propagation of coagulation by activated factor VIII. They detail biophysical, in vitro, and in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e433ece5cb66919dedef92b8e13f3d4
https://pubmed.ncbi.nlm.nih.gov/34077951
https://pubmed.ncbi.nlm.nih.gov/34077951
Autor:
Fabian Stavenuiter, Laurent O. Mosnier
Publikováno v:
Blood. 124:3480-3489
Endothelial barrier protective effects of activated protein C (APC) require the endothelial protein C receptor (EPCR), protease-activated receptor (PAR) 1, and PAR3. In contrast, PAR1 and PAR3 activation by thrombin results in barrier disruption. Non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf13149215bb71fa87a79bee0c3fbb6
https://doi.org/10.1182/blood-2014-06-582775
https://doi.org/10.1182/blood-2014-06-582775
Autor:
Ingrid Bulder, Gerben Marsman, Liza M. Bakker, Femke Stephan, Sacha Zeerleder, Fabian Stavenuiter, Lucien A. Aarden
Publikováno v:
Arthritis & Rheumatology. 66:686-693
Objective Removal of dead cells is essential in the maintenance of tissue homeostasis, and efficient removal prevents exposure of intracellular content to the immune system, which could lead to autoimmunity. The plasma protease factor VII–activatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8029d0786fba7741f3e991e074c6bfc6
https://doi.org/10.1002/art.38265
https://doi.org/10.1002/art.38265
Publikováno v:
Journal of Thrombosis and Haemostasis. 11:242-253
The protein C pathway provides multiple important functions to maintain a regulated balance between haemostasis and host defence systems in response to vascular and inflammatory injury. The anticoagulant protein C pathway is designed to regulate coag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a14a42976076c50a29abd58594062d
https://doi.org/10.1111/jth.12247
https://doi.org/10.1111/jth.12247
Publikováno v:
The FASEB Journal. 27:2918-2925
Protein S (PS) is a multifunctional plasma protein of the hemostatic and inflammatory pathways, although mechanisms for its regulation are poorly understood. Since certain plasma proteins are regulated through extracellular phosphorylation, we invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d513819f485c575d1434b2b62e4507
https://doi.org/10.1096/fj.12-225961
https://doi.org/10.1096/fj.12-225961
Publikováno v:
Thrombosis and Haemostasis. 109:229-237
SummaryAnticoagulant plasma protein S (PS) is essential for maintaining haemostatic balance. About 2.5% of PS is stored in platelets and released upon platelet stimulation. So far, little is known about the functionality and importance of platelet (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6684e0b4bb1725ac8fdfdf381f89f9ab
https://doi.org/10.1160/th12-08-0622
https://doi.org/10.1160/th12-08-0622
Publikováno v:
Thrombosis and haemostasis. 114(6)
SummaryThe protein C (PC) system conveys beneficial anticoagulant and cytoprotective effects in numerous in vivo disease models. The endothelial protein C receptor (EPCR) plays a central role in these pathways as cofactor for PC activation and by enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e038b3bd200f119d55388112550d0dd9
https://pubmed.ncbi.nlm.nih.gov/26272345
https://pubmed.ncbi.nlm.nih.gov/26272345
Autor:
Femke, Stephan, Gerben, Marsman, Liza M, Bakker, Ingrid, Bulder, Fabian, Stavenuiter, Lucien A, Aarden, Sacha, Zeerleder
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 66(3)
Removal of dead cells is essential in the maintenance of tissue homeostasis, and efficient removal prevents exposure of intracellular content to the immune system, which could lead to autoimmunity. The plasma protease factor VII-activating protease (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c767e0516dfded9efa5389372f166e5e
https://pubmed.ncbi.nlm.nih.gov/24574229
https://pubmed.ncbi.nlm.nih.gov/24574229
Autor:
Koen Mertens, Alexander B. Meijer, I. Dienava-Verdoold, H.-J. M. Brinkman, Mariëtte Boon-Spijker, Fabian Stavenuiter
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 10(5)
Summary. Background: Factor seven activating protease (FSAP) was initially reported as an activator of single-chain urokinase-type plasminogen activator (scuPA) and factor VII (FVII). Subsequently, numerous additional substrates have been identified,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db1cdaf4555d4f7d812ebf75138ce43
https://pubmed.ncbi.nlm.nih.gov/22394423
https://pubmed.ncbi.nlm.nih.gov/22394423
Autor:
Laurent O. Mosnier, Fabian Stavenuiter
Publikováno v:
Blood. 124:2802-2802
Introduction: Endothelial barrier protective effects of activated protein C (APC) require the endothelial protein C receptor (EPCR), protease activated receptor 1 (PAR1), and PAR3. In contrast, PAR1 and PAR3 activation by thrombin results in barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1b221a2388fab0bbcf2d5275b97a9e
https://doi.org/10.1182/blood.v124.21.2802.2802
https://doi.org/10.1182/blood.v124.21.2802.2802