Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Fabian Spill"'
Autor:
Patricia Rojas, Jianming Wang, Giovanni Guglielmi, Martina Mustè Sadurnì, Lucas Pavlou, Geoffrey Ho Duen Leung, Vijay Rajagopal, Fabian Spill, Marco Saponaro
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background DNA replication progression can be affected by the presence of physical barriers like the RNA polymerases, leading to replication stress and DNA damage. Nonetheless, we do not know how transcription influences overall DNA replicat
Externí odkaz:
https://doaj.org/article/072a3bf961d1417a9d243d2700149b95
Autor:
Elias Vera-Siguenza, Cristina Escribano-Gonzalez, Irene Serrano-Gonzalo, Kattri-Liis Eskla, Fabian Spill, Daniel Tennant
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011374 (2023)
It is increasingly apparent that cancer cells, in addition to remodelling their metabolism to survive and proliferate, adapt and manipulate the metabolism of other cells. This property may be a telling sign that pre-clinical tumour metabolism studies
Externí odkaz:
https://doaj.org/article/3120aec55e704f36a79cae22cabc2538
Autor:
Yousef Javanmardi, Ayushi Agrawal, Andrea Malandrino, Soufian Lasli, Michelle Chen, Somayeh Shahreza, Bianca Serwinski, Leila Cammoun, Ran Li, Mehdi Jorfi, Boris Djordjevic, Nicolas Szita, Fabian Spill, Sergio Bertazzo, Graham K Sheridan, Vivek Shenoy, Fernando Calvo, Roger Kamm, Emad Moeendarbary
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest on the endothelium, transendothelial migration (TEM), followed by the invasion into the subendothelial extracellular matrix (ECM) of distant tissues
Externí odkaz:
https://doaj.org/article/28f88a3bdf124cc89be1eea1ffbeb641
Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity
Autor:
Eoin McEvoy, Tal Sneh, Emad Moeendarbary, Yousef Javanmardi, Nadia Efimova, Changsong Yang, Gloria E. Marino-Bravante, Xingyu Chen, Jorge Escribano, Fabian Spill, José Manuel Garcia-Aznar, Ashani T. Weeraratna, Tatyana M. Svitkina, Roger D. Kamm, Vivek B. Shenoy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown,
Externí odkaz:
https://doaj.org/article/671f9aee7e3c4eecaf25244cfd1b1fc2
Autor:
Michael Mak, Aurélie Carlier, Fabian Spill, Andrea Malandrino, Mian Long, Maria Jose Gomez-Benito
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/c11d4becceb549f5812f9c6b24f2e92a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 237-245 (2018)
Mechanics and biochemical signaling are both often deregulated in cancer, leading to increased cell invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control basic mechanical properties, such as cell
Externí odkaz:
https://doaj.org/article/25bd2214404b4745be740649cc53e980
Autor:
Jorge Escribano, Michelle B Chen, Emad Moeendarbary, Xuan Cao, Vivek Shenoy, Jose Manuel Garcia-Aznar, Roger D Kamm, Fabian Spill
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 5, p e1006395 (2019)
The formation of gaps in the endothelium is a crucial process underlying both cancer and immune cell extravasation, contributing to the functioning of the immune system during infection, the unfavorable development of chronic inflammation and tumor m
Externí odkaz:
https://doaj.org/article/23b2b81df548466695ac8ade7b6edff9
Chemotherapeutic drugs are used to treat almost all types of cancer, but the intended response, i.e., elimination, is often incomplete, with a subset of cancer cells resisting treatment. Two critical factors play a role in chemoresistance: the p53 tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f66b665306ac290a169416832ec706d
https://doi.org/10.1101/2022.12.07.519451
https://doi.org/10.1101/2022.12.07.519451
Autor:
Shouryadipta, Ghosh, Giovanni, Guglielmi, Ioannis, Orfanidis, Fabian, Spill, Anthony, Hickey, Eric, Hanssen, Vijay, Rajagopal
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 377(1864)
Diabetic cardiomyopathy is a leading cause of heart failure in diabetes. At the cellular level, diabetic cardiomyopathy leads to altered mitochondrial energy metabolism and cardiomyocyte ultrastructure. We combined electron microscopy (EM) and comput
Autor:
Elias Vera-Siguenza, Cristina Escribano-Gonzalez, Irene Serrano-Gonzalo, Kattri-Liis Eskla, Fabian Spill, Daniel Tennant
It is increasingly apparent that cancer cells, in addition to remodelling their metabolism to survive and proliferate, adapt and manipulate the metabolism of other cells. This property may be a telling sign that pre-clinical tumour metabolism studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0efb310c375d04cafb4021a9c5543671
https://doi.org/10.1101/2022.09.12.507672
https://doi.org/10.1101/2022.09.12.507672