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Akademický článek

Neural network-assisted humanisation of COVID-19 hamster transcriptomic data reveals matching severity states in human diseaseResearch in context

Publikováno v: EBioMedicine, Vol 108, Iss , Pp 105312- (2024)

Summary: Background: Translating findings from animal models to human disease is essential for dissecting disease mechanisms, developing and testing precise therapeutic strategies. The coronavirus disease 2019 (COVID-19) pandemic has highlighted this

Externí odkaz: https://doaj.org/article/550b504cdf1443abbb5bb72c0b333a6c

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Akademický článek

Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

Autor: Stefan Peidli, Geraldine Nouailles, Emanuel Wyler, Julia M. Adler, Sandra Kunder, Anne Voß, Julia Kazmierski, Fabian Pott, Peter Pennitz, Dylan Postmus, Luiz Gustavo Teixeira Alves, Christine Goffinet, Achim D. Gruber, Nils Blüthgen, Martin Witzenrath, Jakob Trimpert, Markus Landthaler, Samantha D. Praktiknjo

Publikováno v: Cell Reports, Vol 43, Iss 6, Pp 114328- (2024)

Summary: A key issue for research on COVID-19 pathogenesis is the lack of biopsies from patients and of samples at the onset of infection. To overcome these hurdles, hamsters were shown to be useful models for studying this disease. Here, we further

Externí odkaz: https://doaj.org/article/c99d11239614470a8f8f7a476d42cda0

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Akademický článek

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The immune response is key in determining disease severity of COVID19. Here Nouailles et al., apply bulk proteomics and scRNA-Seq of lung and blood samples of SARS-CoV-2 infected Syrian hamsters and provide a temporal atlas of the systemic and pulmon

Externí odkaz: https://doaj.org/article/072ec28bf61e4f88ac379cb3aa53c111

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Akademický článek

Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Autor: Fabian Pott, Dylan Postmus, Richard J. P. Brown, Emanuel Wyler, Elena Neumann, Markus Landthaler, Christine Goffinet

Publikováno v: Emerging Microbes and Infections, Vol 10, Iss 1, Pp 2151-2168 (2021)

Infection by (re-)emerging RNA arboviruses including Chikungunya virus (CHIKV) and Mayaro virus primarily cause acute febrile disease and transient polyarthralgia. However, in a significant subset of infected individuals, debilitating arthralgia pers

Externí odkaz: https://doaj.org/article/b4572736f4fa4d98b4dc42c21f980331

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Akademický článek

Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

Autor: Simon Schroeder, MSc, Fabian Pott, MSc, Daniela Niemeyer, PhD, Talitha Veith, MPhil, Anja Richter, Doreen Muth, PhD, Christine Goffinet, ProfPhD, Marcel A Müller, PhD, Christian Drosten, ProfPhD

Publikováno v: The Lancet Microbe, Vol 2, Iss 5, Pp e210-e218 (2021)

Summary: Background: The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the viruses share a completely homologous repertoire of proteins and use the

Externí odkaz: https://doaj.org/article/819ce5aee3df4748b4a4a8a997aedc0c

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Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication

Autor: Sarah Krieg, Fabian Pott, Laura Potthoff, Maud Verheirstraeten, Mareike Bütepage, Alexandra Golzmann, Barbara Lippok, Christine Goffinet, Bernhard Lüscher, Patricia Korn

Publikováno v: Cellular and molecular life sciences : (CMLS) 80(3), 72 (2023). doi:10.1007/s00018-023-04717-8

Cellular and molecular life sciences : (CMLS) 80(3), 72 (2023). doi:10.1007/s00018-023-04717-8
Published by Springer International Publishing AG, Cham (ZG)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f277f5fda77165b3d04c94ea835f278
https://lirias.kuleuven.be/handle/20.500.12942/716303

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Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression

Autor: Christine Goffinet, Dylan Postmus, Fabian Pott, Emanuel Wyler, Richard J. C. Brown, Elena Neumann, Markus Landthaler

Publikováno v: Emerging Microbes & Infections
article-version (VoR) Version of Record
Emerging Microbes & Infections, 10:2151-2168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1000e81e355b00ff686deab86ae088
http://europepmc.org/articles/PMC8604527

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