Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

Autor: Tommy Regen, Daniel Jardanhazi-Kurutz, Fabian Nadrigny, Uwe-Karsten Hanisch, Markus P. Kummer, Lucia Dumitrescu-Ozimek, Michael T. Heneka, Ana Martinez-Hernandez, Frank Kirchhoff, Jochen Walter, Dick Terwel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 107(13), 6058-6063 (2010). doi:10.1073/pnas.0909586107
Proceedings of the National Academy of Sciences of the United States of America

Locus ceruleus (LC)-supplied norepinephrine (NE) suppresses neuroinflammation in the brain. To elucidate the effect of LC degeneration and subsequent NE deficiency on Alzheimer's disease pathology, we evaluated NE effects on microglial key functions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc802921fed46432568c030bee61e421
https://pubmed.ncbi.nlm.nih.gov/20419860