Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fabian Muttach"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2819-2832 (2017)
Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparati
Externí odkaz:
https://doaj.org/article/5dfbdefcfc5643d8958c0a4e721c52d3
Autor:
Andrea Rentmeister, Kristina Rau, Freideriki Michailidou, Fabian Muttach, Nicolas V. Cornelissen
Publikováno v:
Chemical Communications
Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are powerful tools to site-specifically introduce a variety of functional groups and exhibit potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d842e13681416dd3aab4b91851261e5
https://doi.org/10.1039/c9cc07807j
https://doi.org/10.1039/c9cc07807j
Autor:
Petr Špaček, Andrea Rentmeister, Armido Studer, Nils Klöcker, Fabian Muttach, Florian Mäsing, Lea Anhäuser
Publikováno v:
Angewandte Chemie. 132:3186-3191
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f559b1444a631249aef3cd14f0e95c57
https://doi.org/10.1002/ange.201914573
https://doi.org/10.1002/ange.201914573
Autor:
Florian Mäsing, Andrea Rentmeister, Fabian Muttach, Armido Studer, Petr Špaček, Nils Klöcker, Lea Anhäuser
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie International Edition
Selective modification of nucleobases with photolabile caging groups enables the study and control of processes and interactions of nucleic acids. Numerous positions on nucleobases have been targeted, but all involve formal substitution of a hydrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914f4547d131e60dde08c8bf39b3bac8
http://europepmc.org/articles/PMC7012642
http://europepmc.org/articles/PMC7012642
Publikováno v:
Chemistry - A European Journal. 23:5988-5993
Elucidation of biomolecular interactions is of utmost importance in biochemistry. Photo-cross-linking offers the possibility to precisely determine RNA-protein interactions. However, despite the inherent specificity of enzymes, approaches for site-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2481b0256b57a6f1c1a2e4b4dcc9cc87
https://doi.org/10.1002/chem.201605663
https://doi.org/10.1002/chem.201605663
Publikováno v:
Chemical Science. 8:7947-7953
Site-specific alkylation of complex biomolecules is critical for late-stage product diversification as well as post-synthetic labeling and manipulation of proteins and nucleic acids. Promiscuous methyltransferases in combination with analogs of S-ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9a5b6ca04143418e2ad712f2c5bbc4d
https://doi.org/10.1039/c7sc03631k
https://doi.org/10.1039/c7sc03631k
Publikováno v:
Organic & Biomolecular Chemistry. 15:278-284
Messenger RNA may not be very abundant in the cell but its central role in gene expression is indisputable. In addition to being the template for translation it can be subject for a variety of regulatory mechanisms affecting gene expression, ranging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b795631929d3ae8f5f96a5ffec4900
https://doi.org/10.1039/c6ob02144a
https://doi.org/10.1039/c6ob02144a
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2008
Photo-cross-linking moieties have proven invaluable for elucidating interactions of biomolecules. While methods for site-specific incorporation of those moieties into proteins have been developed, comparable methods for nucleic acids are lacking. Uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4a1682be3d97c70d156a95254c70779
https://pubmed.ncbi.nlm.nih.gov/31124094
https://pubmed.ncbi.nlm.nih.gov/31124094
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995363
Photo-cross-linking moieties have proven invaluable for elucidating interactions of biomolecules. While methods for site-specific incorporation of those moieties into proteins have been developed, comparable methods for nucleic acids are lacking. Uti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4712ce9e3fd85674f9250d6e10510958
https://doi.org/10.1007/978-1-4939-9537-0_11
https://doi.org/10.1007/978-1-4939-9537-0_11
Autor:
Andrea Rentmeister, Fabian Muttach
Publikováno v:
Methods. 107:3-9
This paper outlines chemically and enzymatically synthesized S-adenosylmethionine (AdoMet) analogs and their use in the site-specific modification of RNA by methyltransferases, enabling the facile attachment of clickable moieties to the nucleic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b57cc32f9f5f19eb8775ba3502ce69
https://doi.org/10.1016/j.ymeth.2016.02.008
https://doi.org/10.1016/j.ymeth.2016.02.008