Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Fabian Krutzek"'
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-24 (2024)
Abstract Background Programmed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has been reported. This was associated with a downregulation of the local immune response, spec
Externí odkaz:
https://doaj.org/article/6b92fb27767c475693a3d55f22417df7
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15088 (2023)
Immune checkpoint inhibitor therapy targeting the PD-1/PD-L1 axis in cancer patients, is a promising oncological treatment. However, the number of non-responders remains high, causing a burden for the patient and the healthcare system. Consequently,
Externí odkaz:
https://doaj.org/article/56795f443dbb478ba14e07561c76fab3
Autor:
Austin Craig, Jürgen Kogler, Fabian Krutzek, Florian Brandt, Markus Laube, Martin Ullrich, Cornelius Kurt Donat, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 127 (2022)
Efficient 18F-fluorination procedures for the production of radiopharmaceuticals are urgently needed to satisfy the increasing demand for clinical diagnostics using positron emission tomography (PET). However, the development of PET tracers is often
Externí odkaz:
https://doaj.org/article/54384e0141a64f7d968e1a127df00aef
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 747 (2022)
Immune checkpoint inhibitor (ICI) therapy has emerged as a major treatment option for a variety of cancers. Among the immune checkpoints addressed, the programmed death receptor 1 (PD-1) and its ligand PD-L1 are the key targets for an ICI. PD-L1 has
Externí odkaz:
https://doaj.org/article/ec4a625cdf6d40b7901dd0c9282fd9e4
Autor:
Fabian Krutzek, Cornelius K. Donat, Martin Ullrich, Kristof Zarschler, Marie-Charlotte Ludik, Anja Feldmann, Liliana R. Loureiro, Klaus Kopka, Sven Stadlbauer
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2638
Cancers 15(2023), 2638
Cancers 15(2023), 2638
Noninvasive molecular imaging of the PD-1/PD-L1 immune checkpoint is of high clinical relevance for patient stratification and therapy monitoring in cancer patients. Here we report nine small-molecule PD-L1 radiotracers with solubilizing sulfonic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46211b5531942ab4d43bf4598ab05790
Autor:
Fabian Krutzek, Cornelius Donat, Martin Ullrich, Liliana Rodrigues Loureiro, Klaus Kopka, Sven Stadlbauer
Publikováno v:
International Symposium on Radiopharmaceutical Sciences, 29.05.-02.06.2022, Nantes, France
Objective: The programmed cell death-ligand 1 (PD-L1) is upregulated on many different cancers and allows the tumor cells to evade immune response through binding to the PD-1 receptor.[1] Monoclonal antibodies, i.e. checkpoint inhibitors, are able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d93a8d8e6f31e7d08194672db5a4b28
https://www.hzdr.de/publications/Publ-35962-1
https://www.hzdr.de/publications/Publ-35962-1
Publikováno v:
Nuclear Medicine and Biology. :S80-S81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::459c39a892acd70a6b6b3174384ab509
https://doi.org/10.1016/s0969-8051(22)00193-7
https://doi.org/10.1016/s0969-8051(22)00193-7
Autor:
Andreas Dreuw, Tobias Kirschbaum, Michael Mastalerz, Frank Rominger, Kevin Baumgärtner, Fabian Krutzek
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 23(70)
Extended fused aromatic compounds are promising materials for organic electronics. Among them, structures with five-membered annulated rings differ from those consisting only of six-membered carbocyclic rings. To date, fusion of five-membered rings h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02168ce786c7d099dc98ca2ef427b5f1
https://pubmed.ncbi.nlm.nih.gov/28977702
https://pubmed.ncbi.nlm.nih.gov/28977702