Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Fabian Konrath"'
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107917- (2023)
Summary: The activation of IKK/NF-κB by genotoxic stress is a crucial process in the DNA damage response. Due to the anti-apoptotic impact of NF-κB, it can affect cell-fate decisions upon DNA damage and therefore interfere with tumor therapy-induce
Externí odkaz:
https://doaj.org/article/19dd6388fc374ac7857349befd9cdd40
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics.
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 6, p e1007901 (2020)
The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crossta
Externí odkaz:
https://doaj.org/article/c75db1df7f4a4c2896588f994787f4d4
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1655 (2021)
Personalized medicine aims to tailor treatment to patients based on their individual genetic or molecular background. Especially in diseases with a large molecular heterogeneity, such as diffuse large B-cell lymphoma (DLBCL), personalized medicine ha
Externí odkaz:
https://doaj.org/article/fa11e8ee04db491da78735748c189709
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003528 (2014)
The transcription factor nuclear factor kappa-B (NFκB) is a key regulator of pro-inflammatory and pro-proliferative processes. Accordingly, uncontrolled NFκB activity may contribute to the development of severe diseases when the regulatory system i
Externí odkaz:
https://doaj.org/article/dc042349a89c4c7887cbf6fdb2b89a8b
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40274 (2012)
Activation of nuclear factor κB (NF-κB) by interleukin-1β (IL-1) usually results in an anti-apoptotic activity that is rapidly terminated by a negative feedback loop involving NF-κB dependent resynthesis of its own inhibitor IκBα. However, apop
Externí odkaz:
https://doaj.org/article/f5eacdb6710f431593a2325859fd99b3
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b01b03f36b43afef35329ade25d869
https://doi.org/10.1007/978-1-0716-3008-2_12
https://doi.org/10.1007/978-1-0716-3008-2_12
Autor:
David, Willnow, Uwe, Benary, Anca, Margineanu, Maria Lillina, Vignola, Fabian, Konrath, Igor M, Pongrac, Zahra, Karimaddini, Alessandra, Vigilante, Jana, Wolf, Francesca M, Spagnoli
Publikováno v:
Nature. 597(7874)
Studies based on single cells have revealed vast cellular heterogeneity in stem cell and progenitor compartments, suggesting continuous differentiation trajectories with intermixing of cells at various states of lineage commitment and notable degrees
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 6, p e1007901 (2020)
PLoS Computational Biology, Vol 16, Iss 6, p e1007901 (2020)
The transcription factors NF-κB and p53 are key regulators in the genotoxic stress response and are critical for tumor development. Although there is ample evidence for interactions between both networks, a comprehensive understanding of the crossta
Autor:
Fabian Konrath
Cells are permanently challenged by DNA damage which can be induced by environmental factors such as UV irradiation or intracellular factors like reactive oxygen species. As damaged DNA can lead to malignant transformations, a complex signaling netwo