Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Fabian Kern"'
Autor:
Annika Engel, Nicole Ludwig, Friederike Grandke, Viktoria Wagner, Fabian Kern, Tobias Fehlmann, Georges P. Schmartz, Ernesto Aparicio-Puerta, Dominic Henn, Barbara Walch-Rückheim, Matthias Hannig, Stefan Rupf, Eckart Meese, Matthias W. Laschke, Andreas Keller
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 31-44 (2024)
Non-thermal plasma, a partially ionized gas, holds significant potential for clinical applications, including wound-healing support, oral therapies, and anti-tumour treatments. While its applications showed promising outcomes, the underlying molecula
Externí odkaz:
https://doaj.org/article/0f8aeea9ae554d44837d51695cf68609
Autor:
Martin Hart, Fabian Kern, Claudia Fecher-Trost, Lena Krammes, Ernesto Aparicio, Annika Engel, Pascal Hirsch, Viktoria Wagner, Verena Keller, Georges Pierre Schmartz, Stefanie Rheinheimer, Caroline Diener, Ulrike Fischer, Jens Mayer, Markus R. Meyer, Veit Flockerzi, Andreas Keller, Eckart Meese
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 4, Pp 935-945 (2024)
Abstract The identification of targetomes remains a challenge given the pleiotropic effect of miRNAs, the limited effects of miRNAs on individual targets, and the sheer number of estimated miRNA–target gene interactions (MTIs), which is around 44,5
Externí odkaz:
https://doaj.org/article/3efe0c622e26455595bea061ca0cb9f0
Autor:
Masood Abu-Halima, Andreas Keller, Lea Simone Becker, Ulrike Fischer, Annika Engel, Nicole Ludwig, Fabian Kern, Trine B. Rounge, Hilde Langseth, Eckart Meese, Verena Keller
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 1-9 (2023)
For cancers and other pathologies, early diagnosis remains the most promising path to survival. Profiling of longitudinal cohorts facilitates insights into trajectories of biomarkers. We measured microRNA expression in 240 serum samples from patients
Externí odkaz:
https://doaj.org/article/510e66b6eacd43e18bfd37cdb72d0f39
Autor:
Fabian Kern, Thomas Kuhn, Nicole Ludwig, Martin Simon, Laura Gröger, Natalie Fabis, Ernesto Aparicio-Puerta, Abdulrahman Salhab, Tobias Fehlmann, Oliver Hahn, Annika Engel, Viktoria Wagner, Marcus Koch, Katarzyna Winek, Hermona Soreq, Irina Nazarenko, Gregor Fuhrmann, Tony Wyss-Coray, Eckart Meese, Verena Keller, Matthias W. Laschke, Andreas Keller
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 482-494 (2023)
Previous work on murine models and humans demonstrated global as well as tissue-specific molecular ageing trajectories of RNAs. Extracellular vesicles (EVs) are membrane vesicles mediating the horizontal transfer of genetic information between differ
Externí odkaz:
https://doaj.org/article/c4f989c3cc3d47828f08997c492f2092
Autor:
Tobias Fehlmann, Benoit Lehallier, Nicholas Schaum, Oliver Hahn, Mustafa Kahraman, Yongping Li, Nadja Grammes, Lars Geffers, Christina Backes, Rudi Balling, Fabian Kern, Rejko Krüger, Frank Lammert, Nicole Ludwig, Benjamin Meder, Bastian Fromm, Walter Maetzler, Daniela Berg, Kathrin Brockmann, Christian Deuschle, Anna-Katharina von Thaler, Gerhard W. Eschweiler, Sofiya Milman, Nir Barziliai, Matthias Reichert, Tony Wyss-Coray, Eckart Meese, Andreas Keller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Aging is a key risk factor for chronic diseases of the elderly. Here the authors perform large-scale miRNA profiling of blood from individuals of a range of ages and show that common diseases alter the physiological age-related blood microRNA profile
Externí odkaz:
https://doaj.org/article/132c3d783c2f4f77b4984be2f3b3481b
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-17 (2020)
Abstract Background Enhancers play a fundamental role in orchestrating cell state and development. Although several methods have been developed to identify enhancers, linking them to their target genes is still an open problem. Several theories have
Externí odkaz:
https://doaj.org/article/6af9954ace1f4ca99906d7c4ef964481
Autor:
Nicole Ludwig, Tobias Fehlmann, Fabian Kern, Manfred Gogol, Walter Maetzler, Stephanie Deutscher, Simone Gurlit, Claudia Schulte, Anna-Katharina von Thaler, Christian Deuschle, Florian Metzger, Daniela Berg, Ulrike Suenkel, Verena Keller, Christina Backes, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 17, Iss 4, Pp 430-440 (2019)
Blood-borne small non-coding (sncRNAs) are among the prominent candidates for blood-based diagnostic tests. Often, high-throughput approaches are applied to discover biomarker signatures. These have to be validated in larger cohorts and evaluated by
Externí odkaz:
https://doaj.org/article/94179eb5c6b74dcfa68e5256fcf611ce
Publikováno v:
Energies, Vol 14, Iss 15, p 4472 (2021)
Low-voltage distribution grids face new challenges through the expansion of decentralized, renewable energy generation and the electrification of the heat and mobility sectors. We present a multi-agent system consisting of the energy management syste
Externí odkaz:
https://doaj.org/article/cc2c8ca2889e4ec0adff80013474f0f5
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1576 (2020)
For many research aspects on small non-coding RNAs, especially microRNAs, computational tools and databases are developed. This includes quantification of miRNAs, piRNAs, tRNAs and tRNA fragments, circRNAs and others. Furthermore, the prediction of n
Externí odkaz:
https://doaj.org/article/792e1ea455084463bdecee77075d5d79
Autor:
Andreas Keller, Nicole Ludwig, Tobias Fehlmann, Mustafa Kahraman, Christina Backes, Fabian Kern, Claus F. Vogelmeier, Caroline Diener, Ulrike Fischer, Frank Biertz, Christian Herr, Rudolf A. Jörres, Hans-Peter Lenhof, Robert Bals, Eckart Meese
Publikováno v:
Cells, Vol 8, Iss 10, p 1162 (2019)
Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of
Externí odkaz:
https://doaj.org/article/e09b38aa81f9401085f00ca677862d3f