Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Fabian K. Eggimann"'
Publikováno v:
Journal of Analytical Science and Technology, Vol 8, Iss 1, Pp 1-7 (2017)
Abstract Background Human UDP-glucuronosyltransferase UGT1A4 is reported to convert a range of tertiary amine substrates to the respective quaternary glucuronides. In this study, we report on the in vitro glucuronidation of a substituted 1H-indazole
Externí odkaz:
https://doaj.org/article/607da0c4cd364910b12f6a16d73bc182
Autor:
Ernst Freund, Dan Huynh, Richard A. Lewis, Eric J. Ma, Markus Stoeckli, Elke Koch, Holger Schlingensiepen, Markus Vogel, Mathieu Ligibel, Radka Snajdrova, Charles Moore, Elina Maria Siirola, Luca Siegrist, Caroline Bouquet, Michael Faller, Edward J. Oakeley, Geoffrey Cutler, Anne-Christine Acker, Fabian K. Eggimann, Arkadij Kummer
Publikováno v:
ACS Catalysis. 11:12433-12445
Autor:
Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau
Publikováno v:
Journal of Medicinal Chemistry
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor
Autor:
Marco Girhard, Florian Tieves, Fabian K. Eggimann, Matthias Kittelmann, Anne Worsch, Kai Sohn, Clemens J von Bühler, Stephan Lütz, Vlada B. Urlacher, Rico Czaja, Christian Grumaz, Andreas Vogel
Publikováno v:
Biotechnology and Bioengineering. 115:2156-2166
Cytochrome P450 mono-oxygenases (P450) are versatile enzymes which play essential roles in C-source assimilation, secondary metabolism, and in degradations of endo- and exogenous xenobiotics. In humans, several P450 isoforms constitute the largest pa
Autor:
Qiong Shen, William C. Forrester, Philipp Krastel, David E. Fisher, Jessi Ambrose, Daniel K. Nomura, Jeremy L. Jenkins, Nathan T. Ross, Lydia H. Zhang, Marc Hild, Akinori Kawakami, Hyelim Cho, Amanda Cobos-Correa, Fabian K. Eggimann, Howard R Miller, Scott Gleim, Frederic Sigoillot, John A. Tallarico, Charles Moore, Philippe Piechon, Ying Wang, Mikiko Okumura, Peter Aspesi, Felipa A. Mapa, Burks Heather Elizabeth, Thomas J. Maimone, Stephen M. Canham, Guglielmo Roma
Publikováno v:
Cell Chemical Biology. 28:1407-1419.e6
Three limonoid natural products with selective anti-proliferative activity against BRAF(V600E) and NRAS(Q61K)-mutation-dependent melanoma cell lines were identified. Differential transcriptome analysis revealed dependency of compound activity on expr
Publikováno v:
Journal of Analytical Science and Technology, Vol 8, Iss 1, Pp 1-7 (2017)
Background Human UDP-glucuronosyltransferase UGT1A4 is reported to convert a range of tertiary amine substrates to the respective quaternary glucuronides. In this study, we report on the in vitro glucuronidation of a substituted 1H-indazole (benzpyra
Autor:
Joseph Schoepfer, Florence Hourcade-Potelleret, Imad Hanna, Petra Priess, Xianbin Tian, Bing Zhu, Heidi J. Einolf, Phi Tran, Tapan Ray, Fabian K. Eggimann, Lai Wang
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(2)
Asciminib is a potent, specific BCR-ABL1 inhibitor being developed for the treatment of patients with chronic myelogenous leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph + ALL).Here, we present the results of huma
Autor:
Alexandra Vargas, Oliver Simon, Matthias Kittelmann, Melissa M. Lin, Chun-qi Zhu, Hongmei Li, Su-Er W. Huskey, Helen Gu, Sarah Favara, Handan He, Jin Zhang, Ry R. Forseth, Lai Wang, Alexandre Luneau, Heidi J. Einolf, Fabian K. Eggimann, James B. Mangold
Publikováno v:
Drug Metabolism and Disposition. 44:653-664
KAE609 [(1'R,3'S)-5,7'-dichloro-6'-fluoro-3'-methyl-2',3',4',9'-tetrahydrospiro[indoline-3,1'-pyridol[3,4-b]indol]-2-one] is a potent, fast-acting, schizonticidal agent being developed for the treatment of malaria. After oral dosing of KAE609 to rats
Autor:
Christian, Grumaz, Yevhen, Vainshtein, Philipp, Kirstahler, Stephan, Luetz, Matthias, Kittelmann, Kirsten, Schroer, Fabian K, Eggimann, Rico, Czaja, Andreas, Vogel, Thomas, Hilberath, Anne, Worsch, Marco, Girhard, Vlada B, Urlacher, Marcel, Sandberg, Kai, Sohn
Publikováno v:
Genome Announcements
The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel t
Autor:
Rico Czaja, Yevhen Vainshtein, Marcel Sandberg, Philipp Kirstahler, Kai Sohn, Andreas Vogel, Thomas Hilberath, Matthias Kittelmann, Stephan Luetz, Anne Worsch, Vlada B. Urlacher, Christian Grumaz, Kirsten Schroer, Marco Girhard, Fabian K. Eggimann
Publikováno v:
Genome Announcements. 5
The three Actinobacteria strains Streptomyces platensis DSM 40041, Pseudonocardia autotrophica DSM 535, and Streptomyces fradiae DSM 40063 were described to selectively oxyfunctionalize several drugs. Here, we present their draft genomes to unravel t