Zobrazeno 1 - 10
of 5 821
pro vyhledávání: '"Fabian J"'
Autor:
Felix Fischer, David S. Fischer, Roman Mukhin, Andrey Isaev, Evan Biederstedt, Alexandra-Chloé Villani, Fabian J. Theis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Identifying cellular identities is a key use case in single-cell transcriptomics. While machine learning has been leveraged to automate cell annotation predictions for some time, there has been little progress in scaling neural networks to l
Externí odkaz:
https://doaj.org/article/238bbc0e49e9451a9362de533c6f954c
Autor:
Fabiola Curion, Charlotte Rich-Griffin, Devika Agarwal, Sarah Ouologuem, Kevin Rue-Albrecht, Lilly May, Giulia E. L. Garcia, Lukas Heumos, Tom Thomas, Wojciech Lason, David Sims, Fabian J. Theis, Calliope A. Dendrou
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-20 (2024)
Abstract Single-cell multiomic analysis of the epigenome, transcriptome, and proteome allows for comprehensive characterization of the molecular circuitry that underpins cell identity and state. However, the holistic interpretation of such datasets p
Externí odkaz:
https://doaj.org/article/fc8d9ca0247842cda6a85765f6c6baf1
Autor:
Benjamin Bay, Marceline M. Fuh, Julia Rohde, Anna Worthmann, Alina Goßling, Natalie Arnold, Lukas Koester, Thiess Lorenz, Christopher Blaum, Paulus Kirchhof, Stefan Blankenberg, Moritz Seiffert, Fabian J. Brunner, Christoph Waldeyer, Joerg Heeren
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Lipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of coronary artery disease (CAD). Here, we aimed to compare lipidomic and bile acid profiles in the b
Externí odkaz:
https://doaj.org/article/a6229e4e270d4438b96d86ae2a432d50
Autor:
Fabiola Curion, Fabian J. Theis
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract The study of immunology, traditionally reliant on proteomics to evaluate individual immune cells, has been revolutionized by single-cell RNA sequencing. Computational immunologists play a crucial role in analysing these datasets, moving beyo
Externí odkaz:
https://doaj.org/article/2018f6f167c94bf2a7bf594ba3daca63
Autor:
Michael P. Trevarrow, Miranda J. Munoz, Yessenia M. Rivera, Rishabh Arora, Quentin H. Drane, Gian D. Pal, Leonard Verhagen Metman, Lisa C. Goelz, Daniel M. Corcos, Fabian J. David
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract The motor impairments experienced by people with Parkinson's disease (PD) are exacerbated during memory‐guided movements. Despite this, the effect of antiparkinson medication on memory‐guided movements has not been elucidated. We evaluat
Externí odkaz:
https://doaj.org/article/5927c8ff3ac64e1ca8f1c1bb4643c685
Autor:
Fabiola Curion, Xichen Wu, Lukas Heumos, Mylene Mariana Gonzales André, Lennard Halle, Matiss Ozols, Melissa Grant-Peters, Charlotte Rich-Griffin, Hing-Yuen Yeung, Calliope A. Dendrou, Herbert B. Schiller, Fabian J. Theis
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Single-cell multiplexing techniques (cell hashing and genetic multiplexing) combine multiple samples, optimizing sample processing and reducing costs. Cell hashing conjugates antibody-tags or chemical-oligonucleotides to cell membranes, whil
Externí odkaz:
https://doaj.org/article/42d6e98537b54ce08caa92cd642b91db
Autor:
Christina Koupourtidou, Veronika Schwarz, Hananeh Aliee, Simon Frerich, Judith Fischer-Sternjak, Riccardo Bocchi, Tatiana Simon-Ebert, Xianshu Bai, Swetlana Sirko, Frank Kirchhoff, Martin Dichgans, Magdalena Götz, Fabian J. Theis, Jovica Ninkovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability and the development of secondary neurodegenerative diseases. A holistic understanding of the mechanisms c
Externí odkaz:
https://doaj.org/article/48c6ec864964436f8a281ba154e18ca0
Autor:
Nicola Masala, Manuel Mittag, Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian J Distler, Peter Rupprecht, Fritjof Helmchen, Rafael Yuste, Martin Fuhrmann, Heinz Beck, Michael Wenzel, Tony Kelly
Publikováno v:
eLife, Vol 13 (2024)
Genetically encoded calcium indicators (GECIs) such as GCaMP are invaluable tools in neuroscience to monitor neuronal activity using optical imaging. The viral transduction of GECIs is commonly used to target expression to specific brain regions, can
Externí odkaz:
https://doaj.org/article/b8900cde3cd141bbb3eac8eba698eaf9
Publikováno v:
Frontiers in Marine Science, Vol 11 (2024)
Ultraviolet radiation (UVR) is the photochemically most reactive waveband of incident solar irradiation. Despite high absorption in aquatic environments, UVR causes numerous biochemical, genetic, and cytotoxic effects in aquatic organisms. To counter
Externí odkaz:
https://doaj.org/article/389edbe7ba60413aa86924eefb58ceb1
Autor:
Benjamin Bay, Christopher Blaum, Caroline Kellner, Ramona Bei der Kellen, Francisco Ojeda, Julia Waibel, Natalie Arnold, Christian-A. Behrendt, David L. Rimmele, Goetz Thomalla, Raphael Twerenbold, Stefan Blankenberg, Birgit Zyriax, Fabian J. Brunner, Christoph Waldeyer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The inflammatory burden as measured by high-sensitivity C-reactive Protein (hsCRP) is recognized as a cardiovascular risk factor, which can however be affected by lifestyle-related risk factors (LRF). Up-to-date the interplay between hsCRP,
Externí odkaz:
https://doaj.org/article/2b12c053f07b42368ca22a1cf28e4d4b