Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Fabian I. Wolter"'
1
Akademický článek
A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer
Autor: Lucia D’Amico, Ulrike Menzel, Michael Prummer, Philipp Müller, Mélanie Buchi, Abhishek Kashyap, Ulrike Haessler, Alexander Yermanos, Rémy Gébleux, Manfred Briendl, Tamara Hell, Fabian I. Wolter, Roger R. Beerli, Iva Truxova, Špíšek Radek, Tatjana Vlajnic, Ulf Grawunder, Sai Reddy, Alfred Zippelius
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Increasing evidence suggests that antibody-drug conjugates (ADCs) can enhance anti-tumor immunity and improve clinical outcome. Here, we elucidate the therapeutic efficacy and immune-mediated mechanisms of a novel HER2-targeting ADC bearing
Externí odkaz: https://doaj.org/article/fc1ae255093f4779af3f20d721a4f07a
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2
Akademický článek
Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells
Autor: Ina Hellmann, Lorenz Waldmeier, Marie-Christine Bannwarth-Escher, Kseniya Maslova, Fabian I. Wolter, Ulf Grawunder, Roger R. Beerli
Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has been identified as a highly relevant tumor-associated antigen in a variety of cancer indications of high unmet medical need, including renal cell carcinoma and osteosarcoma, making it an attr
Externí odkaz: https://doaj.org/article/ef55d8e7150448f1b38fd120d1bb8f25
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5
Data from Highly Potent, Anthracycline-based Antibody–Drug Conjugates Generated by Enzymatic, Site-specific Conjugation
Autor: Roger R. Beerli, Ulf Grawunder, Fabian I. Wolter, Marie Escher, Tamara Hell, Lorenz Waldmeier, Rémy Gébleux, Nikolas Stefan
Antibody–drug conjugates (ADC) are highly potent and specific antitumor drugs, combining the specific targeting of mAbs with the potency of small-molecule toxic payloads. ADCs generated by conventional chemical conjugation yield heterogeneous mixtu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ce4561346675ea9000fdd20167ae48
https://doi.org/10.1158/1535-7163.c.6539398
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6
Highly Potent, Anthracycline-based Antibody–Drug Conjugates Generated by Enzymatic, Site-specific Conjugation
Autor: Roger R. Beerli, Fabian I. Wolter, Ulf Grawunder, Tamara Hell, Lorenz Waldmeier, Rémy Gébleux, Nikolas Stefan, Marie Escher
Publikováno v: Molecular Cancer Therapeutics. 16:879-892
Antibody–drug conjugates (ADC) are highly potent and specific antitumor drugs, combining the specific targeting of mAbs with the potency of small-molecule toxic payloads. ADCs generated by conventional chemical conjugation yield heterogeneous mixtu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a87b09d84dd27038f02279b57c8aa2
https://doi.org/10.1158/1535-7163.mct-16-0688
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7
A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer
Autor: Roger R. Beerli, Špíšek Radek, Alexander Yermanos, Ulrike Menzel, Rémy Gebleux, Manfred Briendl, Fabian I. Wolter, Lucia D'Amico, Melanie Buchi, Sai T. Reddy, Philipp Müller, Ulrike Haessler, Iva Truxova, Alfred Zippelius, Abhishek S. Kashyap, Tatjana Vlajnic, Tamara Hell, Ulf Grawunder, Michael Prummer
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, 7 (1)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-15 (2019)
Increasing evidence suggests that antibody-drug conjugates (ADCs) can enhance anti-tumor immunity and improve clinical outcome. Here, we elucidate the therapeutic efficacy and immune-mediated mechanisms of a novel HER2-targeting ADC bearing a potent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170de8c3b66613b002185d24a48e18de
http://europepmc.org/articles/PMC6341578
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8
Transpo-mAb display: Transposition-mediated B cell display and functional screening of full-length IgG antibody libraries
Autor: Roger R. Beerli, Lorenz Waldmeier, Ulf Grawunder, Sai T. Reddy, Fabian I. Wolter, Ina Hellmann, Chantal K Gutknecht, Skylar C. Cook
Publikováno v: mAbs. 8:726-740
In vitro antibody display and screening technologies geared toward the discovery and engineering of clinically applicable antibodies have evolved from screening artificial antibody formats, powered by microbial display technologies, to screening of n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b16e0ae3d610e81d6a0fc5316bf6f5
https://doi.org/10.1080/19420862.2016.1160990
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9
Novel Antibody Drug Conjugates Targeting Tumor-Associated Receptor Tyrosine Kinase ROR2 by Functional Screening of Fully Human Antibody Libraries Using Transpo-mAb Display on Progenitor B Cells
Autor: Ulf Grawunder, Kseniya Maslova, Roger R. Beerli, Lorenz Waldmeier, Fabian I. Wolter, Marie-Christine Bannwarth-Escher, Ina Hellmann
Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) has been identified as a highly relevant tumor-associated antigen in a variety of cancer indications of high unmet medical need, including renal cell carcinoma and osteosarcoma, making it an attr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796f9ff362c3f0796c6761a6fff05405
http://europepmc.org/articles/PMC6224377
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