Výsledky vyhledávání - "Fabian Heisig"

Fluorescent-Labeled Selective Adenosine A2B Receptor Antagonist Enables Competition Binding Assay by Flow Cytometry

Autor: Christa E. Müller, Andrea Behrenswerth, Katarzyna Kieć-Kononowicz, Meryem Köse, Sabrina Gollos, Fabian Heisig, Vigneshwaran Namasivayam, Tadeusz Karcz, Amelie Fiene

Publikováno v: Journal of Medicinal Chemistry. 61:4301-4316

Fluorescent ligands represent powerful tools for biological studies and are considered attractive alternatives to radioligands. In this study, we developed fluorescent antagonists for A2B adenosine receptors (A2BARs), which are targeted by antiasthma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d4c2c94ca8a0a1c7ff89ed20b2ec56
https://doi.org/10.1021/acs.jmedchem.7b01627

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Fluorescent-Labeled Selective Adenosine A

Autor: Meryem, Köse, Sabrina, Gollos, Tadeusz, Karcz, Amelie, Fiene, Fabian, Heisig, Andrea, Behrenswerth, Katarzyna, Kieć-Kononowicz, Vigneshwaran, Namasivayam, Christa E, Müller

Publikováno v: Journal of medicinal chemistry. 61(10)

Fluorescent ligands represent powerful tools for biological studies and are considered attractive alternatives to radioligands. In this study, we developed fluorescent antagonists for A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbee19ae03b715d3bc6f0938a92aba23
https://pubmed.ncbi.nlm.nih.gov/29681156

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Review of Post-Marketing Safety Data on Tapentadol, a Centrally Acting Analgesic

Autor: Detlef von Zabern, Christian Elling, Melanie Sohns, Fabian Heisig, Ariane Stollenwerk

Publikováno v: Advances in Therapy

Introduction Tapentadol is a centrally acting analgesic that has been available for the management of acute and chronic pain in routine clinical practice since 2009. Methods This is the first integrated descriptive analysis of post-marketing safety d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9267fc1230a23aef38b72645290a6dc7
https://pubmed.ncbi.nlm.nih.gov/29270779

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Long-term Safety and Efficacy of Tapentadol Extended Release Following up to 2 Years of Treatment in Patients With Moderate to Severe, Chronic Pain: Results of an Open-label Extension Trial

Autor: C. Rauschkolb, Stephen A. Rappaport, Robert Buynak, Kevin Rod, Fabian Heisig, Pierre Arsenault, Mila Etropolski

Publikováno v: Clinical therapeutics. 37(11)

Purpose Tapentadol extended release (ER) has demonstrated efficacy and safety for the management of moderate to severe, chronic pain in adults. This study evaluated the long-term safety and tolerability of tapentadol ER in patients with chronic osteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0e2400000ddd53d4080aac4ef4c3ec
https://pubmed.ncbi.nlm.nih.gov/26428249

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Synthesis of BODIPY derivatives substituted with various bioconjugatable linker groups: a construction kit for fluorescent labeling of receptor ligands

Autor: Christa E. Müller, Ali El-Tayeb, Jamshed Iqbal, Fabian Heisig, S. J. Freudenthal, Sabrina Gollos

Publikováno v: Journal of fluorescence. 24(1)

The goal of the present study was to design small, functionalized green-emitting BODIPY dyes, which can readily be coupled to target molecules such as receptor ligands, or even be integrated into their pharmacophores. A simple two-step one-pot proced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02224144c79794f8eeb07791b870cec
https://pubmed.ncbi.nlm.nih.gov/24052460

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Bispidines for Dual Imaging

Autor: Jennifer K. Molloy, Paola Ceroni, Christa E. Müller, Fabian Heisig, Silke Fähnemann, Peter Comba, Holger Stephan, Werner Kraus, Giacomo Bergamini, Martin Walther

Publikováno v: ResearcherID
Chemistry-A European Journal 20(2014), 17011-17018

The efficient transformation of the hexadentate bispidinol 1 into carbamate derivatives yields functional bispidines for the convenient functionalization for targeted imaging. The BODIPY-substituted bispidine 3 combines the coordination site for meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728553409beb94b6fb8476d3a787d752
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=CCC&KeyUT=CCC:000346056600024&KeyUID=CCC:000346056600024

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