Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Fabian Heinemann"'
Autor:
Christian T. Wohnhaas, Kevin Baßler, Carolin K. Watson, Yang Shen, Germán G. Leparc, Cornelia Tilp, Fabian Heinemann, David Kind, Birgit Stierstorfer, Denis Delić, Thomas Brunner, Florian Gantner, Joachim L. Schultze, Coralie Viollet, Patrick Baum
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Smoking is a leading risk factor of chronic obstructive pulmonary disease (COPD), that is characterized by chronic lung inflammation, tissue remodeling and emphysema. Although inflammation is critical to COPD pathogenesis, the cellular and molecular
Externí odkaz:
https://doaj.org/article/63c91076861d42e1acc8a8990681ade0
Autor:
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects about 24% of the world's population. Progression of early stages of NAFLD can lead to the more advanced form non-alcoholic steatohepatitis (NASH), and ultimately to cirrhosis or liver cancer.
Externí odkaz:
https://doaj.org/article/d03e21bdb66a47cf83dafba82490bd38
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 537-541 (2015)
Recently, a new and versatile assay to determine the partitioning coefficient KP as a measure for the affinity of peripheral membrane proteins for lipid bilayers was presented in the research article entitled, “Introducing a fluorescence-based stan
Externí odkaz:
https://doaj.org/article/88fe3b4b949c41aeabada6fbbab908a4
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202708 (2018)
Preclinical studies of novel compounds rely on quantitative readouts from animal models. Frequently employed readouts from histopathological tissue scoring are time consuming, require highly specialized staff and are subject to inherent variability.
Externí odkaz:
https://doaj.org/article/a9aeb372d3454e5c935295c1c30a6c6e
Publikováno v:
eLife, Vol 2 (2013)
Cell cortex remodeling during cell division is a result of myofilament-driven contractility of the cortical membrane-bound actin meshwork. Little is known about the interaction between individual myofilaments and membrane-bound actin filaments. Here
Externí odkaz:
https://doaj.org/article/5bbaf63094e449f1974dd672466b03e5
Publikováno v:
Toxicologic pathology. 50(3)
Convolutional neural networks (CNNs) have been recognized as valuable tools for rapid quantitative analysis of morphological changes in toxicologic histopathology. We have assessed the performance of CNN-based (Halo-AI) mitotic figure detection in he
Autor:
Julia A. Gindele, Haijun Zhang, M.J. Thomas, Ronald G. Crystal, Fabian Heinemann, Michael Brendel, Yael Strulovici-Barel, Kerstin Benediktus, Christian T. Wohnhaas, Birgit Stierstorfer, Gerald Birk, Michelle G. LeBlanc, J. Schymeinsky, Karsten Quast, Tobias Kiechle
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Cigarette smoke (CS) is the leading risk factor to develop COPD. Therefore, the pathologic effects of whole CS on the differentiation of primary small airway epithelial cells (SAEC) were investigated, using cells from three healthy donors and three C
Autor:
Fabian Heinemann, Liesa-Marie Schreiber, Birgit Stierstorfer, Krishna Das, Carles Urbiola, Monika Petersson, Janine Kimpel, Philipp Müller, Patrik Erlmann, Guido Wollmann, Bart Spiesschaert, Dorothee von Laer
Publikováno v:
British Journal of Cancer
Background Oncolytic virotherapy is thought to result in direct virus-induced lytic tumour killing and simultaneous activation of innate and tumour-specific adaptive immune responses. Using a chimeric vesicular stomatitis virus variant VSV-GP, we add
Autor:
Bart Spiesschaert, Philipp Müller, Katharina Angerer, Krishna Das, Tobias Nolden, Carles Urbiola, Judy Ng, Fabian Heinemann, Birgit Stierstorfer, Patrik Erlmann, Guido Wollmann
Publikováno v:
Cancer Research. 82:4193-4193
Introduction: Oncolytic viruses (OVs), which selectively replicate in and destroy tumor cells, form a highly promising class of cancer therapeutics with a strong immune stimulatory potential. VSV-GP, a chimeric Vesicular Stomatitis Virus (VSV) pseudo
Autor:
Sebastian Eder, Igor Zingman, Gerald Birk, Nina Zippel, Leo Thomas, Tanja Schönberger, Birgit Stierstorfer, Fabian Heinemann
Publikováno v:
Toxicologic pathology. 49(4)
Proliferative retinopathies, such as diabetic retinopathy and retinopathy of prematurity, are leading causes of vision impairment. A common feature is a loss of retinal capillary vessels resulting in hypoxia and neuronal damage. The oxygen-induced re