Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fabian Giehler"'
Autor:
Fabian Giehler, Michael S. Ostertag, Thomas Sommermann, Daniel Weidl, Kai R. Sterz, Helmut Kutz, Andreas Moosmann, Stephan M. Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz M. Popowicz, Johannes Kirchmair, Arnd Kieser
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) drives viral B cell transformation and oncogenesis. LMP1’s transforming activity depends on its C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF
Externí odkaz:
https://doaj.org/article/6129e63ef175431f88dcfe4bca0f1328
Autor:
Stefanie Voigt, Kai R. Sterz, Fabian Giehler, Anne-Wiebe Mohr, Joanna B. Wilson, Andreas Moosmann, Arnd Kieser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
IKK2 is the main mediator of the NF-kappaB pathway. Here, the authors demonstrate that LMP1 sustains the survival of Epstein-Barr virus-transformed human B cells and post-transplant lymphoma through IKK2 that induces JNK signaling through TPL2.
Externí odkaz:
https://doaj.org/article/a2305298494b481ca6cef8d55610d0b9
Autor:
Anna Shkoda, Jennifer A Town, Janine Griese, Michael Romio, Hakan Sarioglu, Thomas Knöfel, Fabian Giehler, Arnd Kieser
Publikováno v:
PLoS Biology, Vol 10, Iss 8, p e1001376 (2012)
The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center kinase family. The TNIK functions in hematopoietic cells and the role of TNIK-TRAF interaction
Externí odkaz:
https://doaj.org/article/a79f619f7332437aa3a8c9f9ef747b27
Autor:
Fabian Giehler, Michael Ostertag, Thomas Sommermann, Daniel Weidl, Kai Sterz, Helmut Kutz, Stephan Feller, Arie Geerlof, Brigitte Biesinger, Grzegorz Popowicz, Johannes Kirchmair, Arnd Kieser
The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) drives viral B cell transformation and oncogenesis. LMP1's transforming activity depends on its cytoplasmic C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c49aa69b05fde27bbf65d7b7894f478
https://doi.org/10.21203/rs.3.rs-1295699/v1
https://doi.org/10.21203/rs.3.rs-1295699/v1
Publikováno v:
ChemBioChem. 20:1251-1255
Humans have evolved a natural immunity against Trypanosoma brucei infections, which is executed by two serum (lipo)protein complexes known as trypanolytic factors (TLF). The active TLF ingredient is the primate-specific apolipoprotein L1 (APOL1). The
Autor:
Anne-Wiebe Mohr, Arnd Kieser, Joanna B. Wilson, Andreas Moosmann, Stefanie Voigt, Fabian Giehler, Kai R. Sterz
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nat. Commun. 11:685 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nat. Commun. 11:685 (2020)
IκB kinase 2 (IKK2) is well known for its pivotal role as a mediator of the canonical NF-κB pathway, which has important functions in inflammation and immunity, but also in cancer. Here we identify a novel and critical function of IKK2 and its co-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254d2635c26d127486aab161413a5994
https://eprints.gla.ac.uk/210507/1/210507.pdf
https://eprints.gla.ac.uk/210507/1/210507.pdf
Humans have evolved a natural immunity against Trypanosoma brucei infections, which is executed by two serum (lipo)protein complexes known as trypanolytic factors (TLF). Active TLF-ingredient is the primate-specific apolipoprotein L1 (ApoL1). The pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03f778782e8f4512af2c3f8e23c4457
Autor:
Roy Schrijver, Oliver Soehnlein, Claudia M. van Tiel, Tom Seijkens, Barbara Zarzycka, Tina Ritschel, Tilman M. Hackeng, Sander B. Nabuurs, Jochen Grommes, Gert Vriend, Esther Lutgens, Fabian Giehler, Arnd Kieser, Christian Weber, Gerry A. F. Nicolaes
Publikováno v:
Journal of Chemical Information and Modeling, 55(2), 294-307. American Chemical Society
Journal of chemical information and modeling, 55(2), 294-307. American Chemical Society
Journal of Chemical Information and Modeling, 55, 2, pp. 294-307
Journal of Chemical Information and Modeling, 55, 294-307
Journal of chemical information and modeling, 55(2), 294-307. American Chemical Society
Journal of Chemical Information and Modeling, 55, 2, pp. 294-307
Journal of Chemical Information and Modeling, 55, 294-307
Item does not contain fulltext The CD154-CD40 receptor complex plays a pivotal role in several inflammatory pathways. Attempts to inhibit the formation of this complex have resulted in systemic side effects. Downstream inhibition of the CD40 signalin
Publikováno v:
ChemBioChem. 20:1208-1208