Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Fabian Erdel"'
Autor:
Fernando Muzzopappa, Johan Hummert, Michela Anfossi, Stanimir Asenov Tashev, Dirk-Peter Herten, Fabian Erdel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
It is currently debated how to reliably distinguish liquid–liquid phase separation (LLPS) from other mechanisms. Here the authors report model-free calibrated half-FRAP (MOCHA-FRAP) to probe the barrier at the condensate interface that is responsib
Externí odkaz:
https://doaj.org/article/874443a150d04973b28034e0cceabdb3
Autor:
Ulla Dolde, Fernando Muzzopappa, Charlotte Delesalle, Julie Neveu, Fabian Erdel, Grégory Vert
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106880- (2023)
Summary: The transcription factor LEAFY (LFY) plays crucial roles in flower development by activating floral homeotic genes. Activation of LFY targets requires the combined action of LFY and the E3 ubiquitin ligase UFO, although the precise underlyin
Externí odkaz:
https://doaj.org/article/bd26624624bf4773b8b4eea90e0d57c4
Autor:
Maud Hertzog, Fabian Erdel
Publikováno v:
Cells, Vol 12, Iss 15, p 1958 (2023)
Chromatin regulatory processes physically take place in the environment of the cell nucleus, which is filled with the chromosomes and a plethora of smaller biomolecules. The nucleus contains macromolecular assemblies of different sizes, from nanomete
Externí odkaz:
https://doaj.org/article/76f7117e91604c30bf0fc80ab1e03cc8
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks
Autor:
Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 5, Pp 1-20 (2019)
Abstract In chronic lymphocytic leukemia (CLL), a diverse set of genetic mutations is embedded in a deregulated epigenetic landscape that drives cancerogenesis. To elucidate the role of aberrant chromatin features, we mapped DNA methylation, seven hi
Externí odkaz:
https://doaj.org/article/d531e1d3965044bc9b7dc0b0a7049c9a
Autor:
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Publikováno v:
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://doaj.org/article/8ec54c204be64101928f8e9ebb75bef6
Autor:
Katharina Müller‐Ott, Fabian Erdel, Anna Matveeva, Jan‐Philipp Mallm, Anne Rademacher, Matthias Hahn, Caroline Bauer, Qin Zhang, Sabine Kaltofen, Gunnar Schotta, Thomas Höfer, Karsten Rippe
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 8, Pp 1-22 (2014)
Abstract The cell establishes heritable patterns of active and silenced chromatin via interacting factors that set, remove, and read epigenetic marks. To understand how the underlying networks operate, we have dissected transcriptional silencing in p
Externí odkaz:
https://doaj.org/article/7ec5480278904b7987d9ffaba1bb9dda
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626627
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cde78d54f26a4b50b74bf8e371ac1ff
https://doi.org/10.1007/978-1-0716-2663-4_20
https://doi.org/10.1007/978-1-0716-2663-4_20
Autor:
Fabian Erdel
Publikováno v:
Current Opinion in Structural Biology. 80:102597
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22bc3cf532a0e4704b496752a92d5cad
https://doi.org/10.1016/j.sbi.2023.102597
https://doi.org/10.1016/j.sbi.2023.102597
Autor:
Fabian Erdel
Publikováno v:
Current Opinion in Genetics and Development
Current Opinion in Genetics and Development, Elsevier, 2020, 61, pp.62-68. ⟨10.1016/j.gde.2020.03.006⟩
Current Opinion in Genetics and Development, Elsevier, 2020, 61, pp.62-68. ⟨10.1016/j.gde.2020.03.006⟩
Cells compartmentalize their genome into active and inactive parts that contain distinct histone marks and are differently packaged. Recent work has shed new light on the mechanisms that drive this type of chromatin patterning and the properties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f1b10339521250d7e5f748049d32b6
https://doi.org/10.1016/j.gde.2020.03.006
https://doi.org/10.1016/j.gde.2020.03.006
Autor:
Markus Muckenhuber, Isabelle Lander, Katharina Müller-Ott, Jan-Philipp Mallm, Lara C. Klett, Caroline Knotz, Jana Hechler, Nick Kepper, Fabian Erdel, Karsten Rippe
The antiviral response induced by type I interferon (IFN) via the JAK-STAT signaling cascade activates hundreds of IFN-stimulated genes (ISGs). While this response occurs essentially in all human and mouse tissues it varies between different cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f62fb89bfb392c2bda52ac1faaf4e0e4
https://doi.org/10.1101/2022.02.26.481127
https://doi.org/10.1101/2022.02.26.481127