Zobrazeno 1 - 10 of 62 pro vyhledávání: '"Fabian Dominik Mairinger"'
1
Akademický článek
Tumor cell cytoplasmic metallothionein expression associates with differential tumor immunogenicity and prognostic outcome in high-grade serous ovarian carcinoma
Autor: Elena Mairinger, Michael Wessolly, Paul Buderath, Sabrina Borchert, Larissa Henrich, Pawel Mach, Julia Steinborn, Rainer Kimming, Bharat Jasani, Kurt Werner Schmid, Agnes Bankfalvi, Fabian Dominik Mairinger
Publikováno v: Frontiers in Oncology, Vol 13 (2023)
BackgroundThe underlying mechanism of high T-cell presence as a favorable prognostic factor in high-grade serous ovarian carcinoma (HGSOC) is not yet understood. In addition to immune cells, various cofactors are essential for immune processes. One o
Externí odkaz: https://doaj.org/article/61da0f0817b3496bb034186b8ace0936
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2
Akademický článek
One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy
Autor: Thomas Hager, Sabrina Borchert, Michael Wessolly, Alexander Mathilakathu, Elena Mairinger, Jens Kollmeier, Thomas Mairinger, Balazs Hegedus, Kristina Greimelmaier, Jeremias Wohlschlaeger, Ken Herrmann, Fabian Dominik Mairinger
Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 7, p 6356 (2023)
Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy and chemotherapeutics, with cisplatin being the drug of choice, but response rates of on
Externí odkaz: https://doaj.org/article/af62e333fb3b4b25b1feb1a0f7945c79
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3
Akademický článek
CAF-Associated Paracrine Signaling Worsens Outcome and Potentially Contributes to Chemoresistance in Epithelial Ovarian Cancer
Autor: Michael Wessolly, Elena Mairinger, Sabrina Borchert, Agnes Bankfalvi, Pawel Mach, Kurt Werner Schmid, Rainer Kimmig, Paul Buderath, Fabian Dominik Mairinger
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
BackgroundHigh-grade serous ovarian cancer (HGSOC) is the predominant and deadliest form of ovarian cancer. Some of its histological subtypes can be distinguished by frequent occurrence of cancer-associated myofibroblasts (CAFs) and desmoplastic stro
Externí odkaz: https://doaj.org/article/2d03341162de4358a573bb7f97a982f0
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4
Akademický článek
ACTB, CDKN1B, GAPDH, GRB2, RHOA and SDCBP Were Identified as Reference Genes in Neuroendocrine Lung Cancer via the nCounter Technology.
Autor: Robert Fred Henry Walter, Robert Werner, Claudia Vollbrecht, Thomas Hager, Elena Flom, Daniel Christian Christoph, Jan Schmeller, Kurt Werner Schmid, Jeremias Wohlschlaeger, Fabian Dominik Mairinger
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165181 (2016)
Neuroendocrine lung cancer (NELC) represents 25% of all lung cancer cases and large patient collectives exist as formalin-fixed, paraffin-embedded (FFPE) tissue only. FFPE is controversially discussed as source for molecular biological analyses and r
Externí odkaz: https://doaj.org/article/97c33fa24016449e86d1a9fefb362743
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5
Akademický článek
Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.
Autor: Claudia Vollbrecht, Fabian Dominik Mairinger, Ulrike Koitzsch, Martin Peifer, Katharina Koenig, Lukas Carl Heukamp, Giuliano Crispatzu, Laura Wilden, Karl-Anton Kreuzer, Michael Hallek, Margarete Odenthal, Carmen Diana Herling, Reinhard Buettner
Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129544 (2015)
High resolution molecular studies have demonstrated that the clonal acquisition of gene mutations is an important mechanism that may promote rapid disease progression and drug resistance in chronic lymphocytic leukemia (CLL). Therefore, the early and
Externí odkaz: https://doaj.org/article/6ad8741900c44a7e8f5cabb35c431fb3
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7
Bortezomib sensitivity is tissue dependent and high expression of the 20S proteasome precludes good response in malignant pleural mesothelioma
Autor: Sandra Christoph, Fabian Dominik Mairinger, Thomas Mairinger, Jeremias Wohlschlaeger, Robert Fred Henry Walter, Kurt Werner Schmid, Wilfried Eberhardt, Erika Berg, Jens Kollmeier, Saskia Roxanne Sydow, Daniel C. Christoph
Publikováno v: Cancer Management and Research. 11:8711-8720
Background Bortezomib is an approved proteasome inhibitor for the treatment of certain lymphoma subtypes. Two clinical trials investigated bortezomib in patients with malignant pleural mesothelioma (MPM) and failed to improve outcome. We present a po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::889c1c5d4bac1b702a69d6463e1e1494
https://doi.org/10.2147/cmar.s194337
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10
Impact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma
Autor: Elena Mairinger, Thomas Herold, Balazs Hegedus, Michael Wessolly, Robert Fred Henry Walter, Julia Steinborn, Thomas Hager, Fabian Dominik Mairinger, Sabrina Borchert, Kurt Werner Schmid, Clemens Aigner, Agnes Bankfalvi, Wilfried Eberhardt, Jeremias Wohlschlaeger, Pia-Maria Suckrau
Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal prognosis. Platinum-based chemotherapy is regularly used as part of multimodality therapy. The expression of metallothioneins (MT) has been identified as a reason for ci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5d372e60cbfe5b2f258716c18269c5
https://doi.org/10.1038/s41598-020-75807-x
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