Výsledky vyhledávání - "Fabian C. Schmidt"

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin

Autor: Fabian C. Schmidt, Katja Fitz, Lukas P. Feilen, Masayasu Okochi, Harald Steiner, Dieter Langosch

Publikováno v: The journal of biological chemistry 299(5), 104626 (2023). doi:10.1016/j.jbc.2023.104626

The γ-secretase complex catalyzes the intramembrane cleavage of C99, a carboxy-terminal fragment of the amyloid precursor protein. Two paralogs of its catalytic subunit presenilin (PS1 and PS2) are expressed which are autocatalytically cleaved into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465afc82bce13c0d2b68e62ee6883d03
https://doi.org/10.1016/j.jbc.2023.104626

Zobrazit plný text záznamu

Identifying ionic interactions within a membrane using BLaTM, a genetic tool to measure homo- and heterotypic transmembrane helix-helix interactions

Autor: Christoph Schanzenbach, Fabian C. Schmidt, Patrick Breckner, Mark G. Teese, Dieter Langosch

Publikováno v: Scientific Reports

The assembly of integral membrane protein complexes is frequently supported by transmembrane domain (TMD) interactions. Here, we present the BLaTM assay that measures homotypic as well as heterotypic TMD-TMD interactions in a bacterial membrane. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5f796afb52a06e867eae8771931c0a69
https://pubmed.ncbi.nlm.nih.gov/32332822

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání