Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists

Autor: Sven Marcel Stefan, Jiyang Li, Gerd Bendas, Vigneshwaran Namasivayam, Fabian Baltes, Katja Silbermann, Michael Wiese

Publikováno v: Journal of Medicinal Chemistry. 63:10412-10432

In the search for highly effective modulators addressing ABCG2-mediated MDR, 23 pyrimidines were synthesized and biologically assessed. Seven derivatives with (a) nitrogen- and/or halogen-containing residue(s) had extraordinary potencies against ABCG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce264c4353ccafe77f7d33d9470e11d
https://doi.org/10.1021/acs.jmedchem.0c00961

Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β1-integrin Emerges as a Key Factor for Breast Cancer Chemosensitization upon Collagen Type 1 Binding

Autor: Julia Caspers, Fabian Baltes, Gerd Bendas, Martin Schlesinger, Svenja Henze

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 4956, p 4956 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 14

Collagen type 1 (COL1) is a ubiquitously existing extracellular matrix protein whose high density in breast tissue favors metastasis and chemoresistance. COL1-binding of MDA-MB-231 and MCF-7 breast cancer cells is mainly dependent on &beta
1-int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a905e199b76cdb11dbaed38d1232b9c8
https://www.mdpi.com/1422-0067/21/14/4956

β1-Integrin binding to collagen type 1 transmits breast cancer cells into chemoresistance by activating ABC efflux transporters

Autor: Fabian Baltes, Gerd Bendas, Martin Schlesinger, Katja Silbermann, Kathleen Wantoch von Rekowski, Julia Caspers, Vladlena Pfeifer

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1867:118663

Molecular interactions of tumor cells with the microenvironment are regarded as onset of chemotherapy resistance, referred to as cell adhesion mediated drug resistance (CAM-DR). Here we elucidate a mechanism of CAM-DR in breast cancer cells in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f129c0ec61af9ace319db74811fac7c3
https://doi.org/10.1016/j.bbamcr.2020.118663

Heparin antagonizes cisplatin resistance of A2780 ovarian cancer cells by affecting the Wnt signaling pathway

Autor: Fabian Baltes, Gerd Bendas, Martin Schlesinger, Daniel Bastian Pfankuchen, Jin-Ping Li, Tahira Batool

Publikováno v: Oncotarget

// Daniel Bastian Pfankuchen 1 , Fabian Baltes 1 , Tahira Batool 2 , Jin-Ping Li 2 , Martin Schlesinger 1 and Gerd Bendas 1 1 Pharmaceutical Institute, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany 2 Department of Medical Biochemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedc09a5cd81eb676d95dce79d56e17d
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336049