Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Fabian, Hulpia"'
Autor:
Dorien Mabille, Kayhan Ilbeigi, Sarah Hendrickx, Marzuq A. Ungogo, Fabian Hulpia, Cai Lin, Louis Maes, Harry P. de Koning, Serge Van Calenbergh, Guy Caljon
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 19, Iss , Pp 21-30 (2022)
Animal trypanosomiasis (AT) is a parasitic disease with high socio-economic impact. Given the limited therapeutic options and problems of toxicity and drug resistance, this study assessed redirecting our previously identified antitrypanosomal nucleos
Externí odkaz:
https://doaj.org/article/67220a1220024591ad64ccc816d06c7e
Autor:
Cai Lin, Fabian Hulpia, Izet Karalic, Laurens De Schepper, Louis Maes, Guy Caljon, Serge Van Calenbergh
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 57-66 (2021)
Kinetoplastid parasites are the causative agents of Chagas disease (CD), leishmaniasis and human African trypanosomiasis (HAT). Despite a sustained decrease in the number of HAT cases, more efforts are needed to discover safe and effective therapies
Externí odkaz:
https://doaj.org/article/a482b44f49a740799353ff42d4fea40a
Autor:
Fabian Hulpia, Dorien Mabille, Gustavo D. Campagnaro, Gabriela Schumann, Louis Maes, Isabel Roditi, Anders Hofer, Harry P. de Koning, Guy Caljon, Serge Van Calenbergh
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Trypanosoma brucei relies on uptake and conversion of purines from the host, which constitutes a potential drug target. Here, Hulpia et al. combine structural elements from known trypanocidal nucleoside analogues and develop a potent trypanocide with
Externí odkaz:
https://doaj.org/article/ac12d894b82c4ecab2670dd0dcf7314e
Autor:
Ludmila F. de A. Fiuza, Denise G. J. Batista, Roberson D. Girão, Fabian Hulpia, Paula Finamore-Araújo, Mustafa M. Aldfer, Ehab Kotb Elmahallawy, Harry P. De Koning, Otacílio Moreira, Serge Van Calenbergh, Maria de Nazaré C. Soeiro
Publikováno v:
Molecules, Vol 27, Iss 22, p 8087 (2022)
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), is a serious public health problem. Current treatment is restricted to two drugs, benznidazole and nifurtimox, displaying serious efficacy and safety drawbacks. Nucleoside analogues represent a
Externí odkaz:
https://doaj.org/article/876b03b2f5ac4a6a80705f7e7691022f
Autor:
Ali H Alghamdi, Jane C Munday, Gustavo Daniel Campagnaro, Dominik Gurvic, Fredrik Svensson, Chinyere E Okpara, Arvind Kumar, Juan Quintana, Maria Esther Martin Abril, Patrik Milić, Laura Watson, Daniel Paape, Luca Settimo, Anna Dimitriou, Joanna Wielinska, Graeme Smart, Laura F Anderson, Christopher M Woodley, Siu Pui Ying Kelly, Hasan MS Ibrahim, Fabian Hulpia, Mohammed I Al-Salabi, Anthonius A Eze, Teresa Sprenger, Ibrahim A Teka, Simon Gudin, Simone Weyand, Mark Field, Christophe Dardonville, Richard R Tidwell, Mark Carrington, Paul O'Neill, David W Boykin, Ulrich Zachariae, Harry P De Koning
Publikováno v:
eLife, Vol 9 (2020)
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively selected for increased pore size from a common ancestor aquaporin. We demonstrate that
Externí odkaz:
https://doaj.org/article/04cf21046dd94dac9faba5a20eaa5348
Autor:
Dorien Mabille, Camila Cardoso Santos, Rik Hendrickx, Mathieu Claes, Peter Takac, Christine Clayton, Sarah Hendrickx, Fabian Hulpia, Louis Maes, Serge Van Calenbergh, Guy Caljon
Publikováno v:
Microorganisms, Vol 9, Iss 4, p 826 (2021)
Human African trypanosomiasis is a neglected parasitic disease for which the current treatment options are quite limited. Trypanosomes are not able to synthesize purines de novo and thus solely depend on purine salvage from the host environment. This
Externí odkaz:
https://doaj.org/article/297c4da012bb407399bfa62aa9b015d0
Autor:
Yanlin Jian, Fabian Hulpia, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Hélène Munier-Lehmann, Helena I. M. Boshoff, Serge Van Calenbergh
Publikováno v:
Molecules, Vol 25, Iss 12, p 2805 (2020)
A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modif
Externí odkaz:
https://doaj.org/article/9335a1cb31644688b92dd36518d8dfcd
Autor:
Erine Craey, Fabian Hulpia, Jeroen Spanoghe, Simona Manzella, Lars E. Larsen, Mathieu Sprengers, Dimitri De Bundel, Ilse Smolders, Evelien Carrette, Jean Delbeke, Kristl Vonck, Paul Boon, Serge Van Calenbergh, Wytse J. Wadman, Robrecht Raedt
Publikováno v:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
We report the design, synthesis, and validation of the novel compound photocaged N6-cyclopentyladenosine (cCPA) to achieve precisely localized and timed release of the parent adenosine A1 receptor agonist CPA using 405 nm light. Gi protein-coupled A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c98c5310b1e3c6564d628b53fadbb5
https://pubmed.ncbi.nlm.nih.gov/36012151
https://pubmed.ncbi.nlm.nih.gov/36012151
Autor:
Alex J Krotulski, Serge Van Calenbergh, Christophe P. Stove, Marthe M Vandeputte, Fabian Hulpia
Publikováno v:
Journal of Analytical Toxicology. 46:350-357
Profiling of the illicit fentanyl supply is invaluable from surveillance and intelligence perspectives. An important strategy includes the study of chemical attribution signatures (e.g., trace amounts of synthesis precursors, impurities/byproducts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a69cc632af26a8bf0b689b8f0c5afd
https://doi.org/10.1093/jat/bkab032
https://doi.org/10.1093/jat/bkab032
Autor:
Serge Van Calenbergh, Fabian Hulpia, Helena I. Boshoff, Martijn D. P. Risseeuw, He Eun Forbes, Guy Caljon, Yanlin Jian, Hélène Munier-Lehmann
Publikováno v:
Journal of medicinal chemistry
Swapping the substituents in positions 2 and 4 of the previously synthesized but yet undisclosed 5-cyano-4-(methylthio)-2-arylpyrimidin-6-ones 4, ring closure, and further optimization led to the identification of the potent antitubercular 2-thio-sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c7c7f323754a0570c590fd5ef79aa2
https://doi.org/10.1021/acs.jmedchem.0c01374
https://doi.org/10.1021/acs.jmedchem.0c01374