Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Fabian, Hässler"'
Autor:
Matteo Villa, David E. Sanin, Petya Apostolova, Mauro Corrado, Agnieszka M. Kabat, Carmine Cristinzio, Annamaria Regina, Gustavo E. Carrizo, Nisha Rana, Michal A. Stanczak, Francesc Baixauli, Katarzyna M. Grzes, Jovana Cupovic, Francesca Solagna, Alexandra Hackl, Anna-Maria Globig, Fabian Hässler, Daniel J. Puleston, Beth Kelly, Nina Cabezas-Wallscheid, Peter Hasselblatt, Bertram Bengsch, Robert Zeiser, Sagar, Joerg M. Buescher, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool.
Externí odkaz:
https://doaj.org/article/94dc27161c6a48b2b42944d1f1be38af
Autor:
Angela Castoldi, Lauar B. Monteiro, Nikki van Teijlingen Bakker, David E. Sanin, Nisha Rana, Mauro Corrado, Alanna M. Cameron, Fabian Hässler, Mai Matsushita, George Caputa, Ramon I. Klein Geltink, Jörg Büscher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
As macrophages switch to a proinflammatory gylcolytic state they start to generate triglyceride-rich lipid droplets, but what function these droplets have in this context is not clear. Here the authors show that this triglyceride synthesis is requisi
Externí odkaz:
https://doaj.org/article/e66368483cc344ee9854c2ede5bf41d5
Publikováno v:
Radiology Case Reports, Vol 12, Iss 1, Pp 39-41 (2017)
A 76-year-old male patient was admitted to our emergency department with painful swelling of the right lateral chest after a fall. Imaging revealed a hematoma, secondary to rupture of a synthetic axilloprofundal bypass. In an emergency surgical proce
Externí odkaz:
https://doaj.org/article/af1f7585f7704fbb87a3fa36bb20caea
Autor:
George Caputa, Mai Matsushita, David E. Sanin, Agnieszka M. Kabat, Joy Edwards-Hicks, Katarzyna M. Grzes, Roland Pohlmeyer, Michal A. Stanczak, Angela Castoldi, Jovana Cupovic, Aaron J. Forde, Petya Apostolova, Maximilian Seidl, Nikki van Teijlingen Bakker, Matteo Villa, Francesc Baixauli, Andrea Quintana, Alexandra Hackl, Lea Flachsmann, Fabian Hässler, Jonathan D. Curtis, Annette E. Patterson, Philipp Henneke, Erika L. Pearce, Edward J. Pearce
Publikováno v:
Cell Metabolism
Adipose tissue (AT) plays a central role in systemic metabolic homeostasis, but its function during bacterial infection remains unclear. Following subcutaneous bacterial infection, adipocytes surrounding draining lymph nodes initiated a transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51dacb6a3f83c6d05f1337f75c1e6683
https://hdl.handle.net/21.11116/0000-000D-1585-521.11116/0000-000D-1587-3
https://hdl.handle.net/21.11116/0000-000D-1585-521.11116/0000-000D-1587-3
Autor:
Mai Matsushita, Angela Castoldi, Edward J. Pearce, Mauro Corrado, Nisha Rana, George Caputa, Nikki van Teijlingen Bakker, Alanna M. Cameron, Jörg Büscher, Ramon I. Klein Geltink, Lauar B. Monteiro, Joy Edwards-Hicks, David E. Sanin, Fabian Hässler, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Foamy macrophages, which have prominent lipid droplets (LDs), are found in a variety of disease states. Toll-like receptor agonists drive triacylglycerol (TG)-rich LD development in macrophages. Here we explore the basis and significance of this proc
Autor:
Edward J. Pearce, Angela Castoldi, Joerg M. Buescher, Lea J. Flachsmann, Fabian Hässler, Ryan Kyle, Annette E. Patterson, David E. Sanin, Daniel J. Puleston, Alanna M. Cameron, Beth Kelly, Cameron S. Field, Erika L. Pearce
Publikováno v:
Nature Immunology
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzy
Autor:
Jonathan D. Curtis, Petya Apostolova, Edward J. Pearce, Joerg M. Buescher, Erika L. Pearce, Annette E. Patterson, Fabian Hässler, David E. Sanin, Franziska M. Uhl, Michal A. Stanczak, David O’Sullivan, Robert Zeiser, Joy Edwards-Hicks, Nina A M Ligthart, Daniel J. Puleston, Katarzyna M. Grzes, Ramon I. Klein Geltink, Mario Fabri, Agnieszka M. Kabat
Publikováno v:
Nature Metabolism
CD8+ effector T (TE) cell proliferation and cytokine production depends on enhanced glucose metabolism. However, circulating T cells continuously adapt to glucose fluctuations caused by diet and inter-organ metabolite exchange. Here we show that tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527fdf8f9482ead8f3a9e4d7a8815d74
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
https://hdl.handle.net/21.11116/0000-0006-CF32-921.11116/0000-0006-CF34-7
Autor:
Cameron S. Field, Marcin Kamiński, Francesc Baixauli, Edward J. Pearce, Douglas R. Green, Stanckzak M, Yaarub Musa, Schimmelpfennig L, Chong Wang, Erika L. Pearce, Matteo Villa, Katarzyna M. Grzes, Joerg M. Buescher, Vijay K. Kuchroo, Lea J. Flachsmann, Fabian Hässler, Agnieszka M. Kabat, Gerhard Mittler, Daniel J. Puleston, David E. Sanin, Weiss H, Nir Yosef, Stefan Balabanov
SUMMARYWe report here a central role for polyamines in T cell differentiation and function. Deficiency in ornithine decarboxylase (ODC), a critical enzyme for polyamine synthesis, resulted in a profound failure of CD4+ T cells to adopt correct subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc853f69460a68a0c83eaf866e22e6a
https://doi.org/10.1101/2020.01.24.918094
https://doi.org/10.1101/2020.01.24.918094
Autor:
Ramon I, Klein Geltink, Joy, Edwards-Hicks, Petya, Apostolova, David, O'Sullivan, David E, Sanin, Annette E, Patterson, Daniel J, Puleston, Nina A M, Ligthart, Joerg M, Buescher, Katarzyna M, Grzes, Agnieszka M, Kabat, Michal, Stanczak, Jonathan D, Curtis, Fabian, Hässler, Franziska M, Uhl, Mario, Fabri, Robert, Zeiser, Edward J, Pearce, Erika L, Pearce
Publikováno v:
Nature metabolism. 2(8)
CD8
Autor:
Alanna M, Cameron, Angela, Castoldi, David E, Sanin, Lea J, Flachsmann, Cameron S, Field, Daniel J, Puleston, Ryan L, Kyle, Annette E, Patterson, Fabian, Hässler, Joerg M, Buescher, Beth, Kelly, Erika L, Pearce, Edward J, Pearce
Publikováno v:
Nature immunology. 20(4)
The adoption of Warburg metabolism is critical for the activation of macrophages in response to lipopolysaccharide. Macrophages stimulated with lipopolysaccharide increase their expression of nicotinamide phosphoribosyltransferase (NAMPT), a key enzy