Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Fabian, Grein"'
Autor:
Lea Antje Adolf, Angelika Müller-Jochim, Lara Kricks, Jan-Samuel Puls, Daniel Lopez, Fabian Grein, Simon Heilbronner
Publikováno v:
eLife, Vol 12 (2023)
Sufficient access to transition metals such as iron is essential for bacterial proliferation and their active limitation within host tissues effectively restricts infection. To overcome iron limitation, the invasive pathogen Staphylococcus aureus use
Externí odkaz:
https://doaj.org/article/ccf7a63fc78b427b847420d8462a612f
Autor:
Julia P. Deisinger, Melina Arts, Ioli Kotsogianni, Jan-Samuel Puls, Fabian Grein, Francisco Javier Ortiz-López, Nathaniel I. Martin, Anna Müller, Olga Genilloud, Tanja Schneider
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106394- (2023)
Summary: Antibiotic resistance is reaching alarming levels, demanding for the discovery and development of antibiotics with novel chemistry and mechanisms of action. The recently discovered antibiotic cacaoidin combines the characteristic lanthionine
Externí odkaz:
https://doaj.org/article/82a0b81353d2487f907b093a53470d73
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1792 (2023)
When oxidizing reduced sulfur compounds, the phototrophic sulfur bacterium Allochromatium vinosum forms spectacular sulfur globules as obligatory intracellular–but extracytoplasmic–intermediates. The globule envelope consists of three extremely h
Externí odkaz:
https://doaj.org/article/ca3258a253fa4e568db3513992d6b8f3
Autor:
Fabian Grein, Anna Müller, Katharina M. Scherer, Xinliang Liu, Kevin C. Ludwig, Anna Klöckner, Manuel Strach, Hans-Georg Sahl, Ulrich Kubitscheck, Tanja Schneider
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The mechanism of action of daptomycin, a lipopeptidic antibiotic, is unclear. Here, the authors show that Ca2+-daptomycin simultaneously interacts with lipid-coupled precursors of the bacterial cell envelope and with the anionic phospholipid phosphat
Externí odkaz:
https://doaj.org/article/3f8afa07193d465fb47aa48692257131
Autor:
Prabhjot Kaur, Marvin Rausch, Basanti Malakar, Uchenna Watson, Nikhil P. Damle, Yogesh Chawla, Sandhya Srinivasan, Kanika Sharma, Tanja Schneider, Gagan Deep Jhingan, Deepak Saini, Debasisa Mohanty, Fabian Grein, Vinay Kumar Nandicoori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a h
Externí odkaz:
https://doaj.org/article/229dcd6f9fca48209698162286590a15
Autor:
Rhythm Shukla, Aaron J. Peoples, Kevin C. Ludwig, Sourav Maity, Maik G.N. Derks, Stefania de Benedetti, Annika M Krueger, Bram J.A. Vermeulen, Francesca Lavore, Rodrigo V. Honorato, Fabian Grein, Alexandre Bonvin, Ulrich Kubitscheck, Eefjan Breukink, Catherine Achorn, Anthony Nitti, Christopher J. Schwalen, Amy L. Spoering, Losee Lucy Ling, Dallas Hughes, Moreno Lelli, Wouter H. Roos, Kim Lewis, Tanja Schneider, Markus Weingarth
Publikováno v:
bioRxiv
SummaryAntimicrobial resistance is a leading mortality factor worldwide. Here we report the discovery of clovibactin, a new antibiotic, isolated from uncultured soil bacteria. Clovibactin efficiently kills drug-resistant bacterial pathogens without d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a194cd4955538bc1ed55a40015678a
https://europepmc.org/articles/PMC10245560/
https://europepmc.org/articles/PMC10245560/
Inhibition of peptidoglycan synthesis is sufficient for total arrest of staphylococcal cell division
Publikováno v:
Science Advances. 9
Bacterial cell wall biosynthesis is the target of many important antibiotics. Its spatiotemporal organization is closely coordinated with cell division. However, the role of peptidoglycan synthesis within cell division is not fully understood. Even l
Autor:
Lea Antje Adolf, Angelika Müller-Jochim, Lara Kricks, Jan-Samuel Puls, Daniel Lopez, Fabian Grein, Simon Heilbronner
Sufficient access to transition metals such as iron is essential for bacterial proliferation and their active limitation within host tissues effectively restricts infection. To overcome iron limitation, the invasive pathogenStaphylococcus aureususes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01c2e2363b3b29c4698c5aeaceda2381
https://doi.org/10.1101/2023.01.11.523574
https://doi.org/10.1101/2023.01.11.523574
Autor:
Michael A. Morris, Alexander Vallmitjana, Fabian Grein, Tanja Schneider, Melina Arts, Chelsea R. Jones, Betty T. Nguyen, Mohammad H. Hashemian, Melody Malek, Enrico Gratton, James S. Nowick
Publikováno v:
Chemical Science. 13:7747-7754
FRET microscopy experiments demonstrate supramolecular assembly of teixobactin molecules on Bacillus subtilis, providing further evidence that teixobactin is a supramolecular antibiotic.