Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Fabia de Oliveira Andrade"'
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Akademický článek
Social Isolation Activates Dormant Mammary Tumors, and Modifies Inflammatory and Mitochondrial Metabolic Pathways in the Rat Mammary Gland
Autor: Fabia de Oliveira Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke
Publikováno v: Cells, Vol 12, Iss 6, p 961 (2023)
Although multifactorial in origin, one of the most impactful consequences of social isolation is an increase in breast cancer mortality. How this happens is unknown, but many studies have shown that social isolation increases circulating inflammatory
Externí odkaz: https://doaj.org/article/6c0ca74964b34fddba43f3f77a7b7c77
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2
Akademický článek
Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice
Autor: Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis, Leena Hilakivi-Clarke
Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-13 (2017)
Abstract Background Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primor
Externí odkaz: https://doaj.org/article/dbe31791a3c543a396728f625039585b
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3
Abstract P3-11-08: Inhibition of Sirtuin 3 Sensitizes Breast Cancer Cells to Fulvestrant
Autor: Karla Andrade de Oliveira, Surojeet Sengupta, Lu Jin, Fabia de Oliveira Andrade, Melike Ozgu-Onal, Anil Yadav, Robert Clarke
Publikováno v: Cancer Research. 83:P3-11
Endocrine therapy can lead to nutrient deprivation by reducing glucose and glutamine uptake and total cellular ATP production. The ability of cells to bypass this metabolic stress is fundamental to how they regulate BC growth and acquire endocrine re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ee3346b150a2821fb49f5e552f1606
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-08
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4
Abstract P3-06-05: Effects of isoflavone genistein, combined with anti-estrogen fulvestrant, on anti-PD1 therapy response against E0771 mammary tumors in mice
Autor: Fabia de Oliveira Andrade, Vivek Verma, Ester Molina Hoyo, Karla Andrade de Oliveira, Pal Koak, Lu Jin, Leena Hilakivi-Clarke
Publikováno v: Cancer Research. 83:P3-06
Although immune checkpoint blockers (ICBs) have revolutionized the treatment of many cancers, only less than 30% of patients respond to any ICB as a monotherapy. Estrogens, produced by the adipose tissue in the mammary glands, are immunomodulators in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f09210c40cab537cc1205c2e15dde07
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-05
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5
Foods may modify responsiveness to cancer immune checkpoint blockers by altering both the gut microbiota and activation of estrogen receptors in immune cells
Autor: Leena Hilakivi-Clarke, Vivek Verma, Maddie McDermott, Pal Koak, Fabia de Oliveira Andrade
Publikováno v: Frontiers in Microbiomes. 1
Estrogen receptor alpha positive (ERα+) breast cancers are refractory to immune checkpoint blocker (ICB) monotherapy, while ICBs are part of a standard of care for triple negative breast cancers (TNBCs). Besides tumor ERα expression, another differ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07316c4b1dd79aa0a33dd9d40a187e2b
https://doi.org/10.3389/frmbi.2022.1049688
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6
Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis
Autor: Fabia de Oliveira Andrade, Vivek Verma, Leena Hilakivi‐Clarke
Publikováno v: Cancer Reports. 5
About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deb09aa7ce30836358ec2fb49dc8d23
https://doi.org/10.1002/cnr2.1752
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7
Abstract P6-05-16: Social isolation induces gut dysbiosis, mitochondrial metabolic dysfunction, and infiltration of tumor immunosuppressive cells: do they explain enhanced mammary tumorigenesis?
Autor: Fabia de Oliveira Andrade, Lu Jin, Vivek Verma, Maddie McDermott, Chris Staley, Leena Hilakivi-Clarke
Publikováno v: Cancer Research. 83:P6-05
Inadequate social contacts and loneliness, often referred to as social isolation (SI), are associated with increased mortality from many diseases, including breast cancer. Up to 41% of breast cancer patients have been identified as feeling socially i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::142e7e8af093dff79d6fca66f0f5066b
https://doi.org/10.1158/1538-7445.sabcs22-p6-05-16
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10
Abstract 1603: Valproic acid and hydralazine reverse increased mammary cancer risk and upregulate Cdkn2a/p16 in mice exposed to a high fat diet in utero
Autor: Fabia de Oliveira Andrade, Leena Hilakivi-Clarke, Nguyen Nguyen, Kerrie B. Bouker
Publikováno v: Cancer Research. 79:1603-1603
Maternal or paternal high fat (HF) diet that modifies the epigenome in germ cells and fetal somatic cells can program increased susceptibility to breast cancer among offspring. Resulting epigenetic changes include transgenerational upregulation of DN
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc09f84802eb17b02994711dbab64723
https://doi.org/10.1158/1538-7445.am2019-1603
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