Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Fabia Febbraro"'
Autor:
Muyesier Maimaitili, Muwan Chen, Fabia Febbraro, Ekin Ucuncu, Rachel Kelly, Jonathan Christos Niclis, Josefine Rågård Christiansen, Noëmie Mermet-Joret, Dragos Niculescu, Johanne Lauritsen, Angelo Iannielli, Ida H. Klæstrup, Uffe Birk Jensen, Per Qvist, Sadegh Nabavi, Vania Broccoli, Anders Nykjær, Marina Romero-Ramos, Mark Denham
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing only a small proportion of mesDA neurons when transplanted in vivo. In this study, we d
Externí odkaz:
https://doaj.org/article/cabafdbe91e44ff087afd66e98f70397
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Vacuolar protein sorting 10 protein (VPS10P) domain receptors are a unique class of intracellular sorting receptors that emerge as major risk factors associated with psychiatric and neurodegenerative diseases, including bipolar disorders, autism, sch
Externí odkaz:
https://doaj.org/article/66476f9988fe49ff8965d36edca1ce8f
Autor:
Muwan Chen, Muyesier Maimaitili, Mette Habekost, Katherine P. Gill, Noëmie Mermet-Joret, Sadegh Nabavi, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101945- (2020)
The differentiation of patient-specific induced pluripotent stem cells (iPSCs) into specific neuronal subtypes has been exploited as an approach for modeling a variety of neurological disorders. However, achieving a highly pure population of neurons
Externí odkaz:
https://doaj.org/article/22eaa1b9a92d4a05ac9f38b727a66b06
Autor:
Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
We generated an induced pluripotent stem cell (iPSC) line from fibroblasts of a clinically diagnosed 70 year old female Parkinson's disease (PD) patient heterozygous for a pathogenic missense variant (p.G2019S; c. 6055 G > A) in the leucine-rich repe
Externí odkaz:
https://doaj.org/article/a393827b102b4353ae071d07fdffc349
Autor:
Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 42, Iss , Pp - (2020)
We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes includin
Externí odkaz:
https://doaj.org/article/2763008b69d0437fb19115ea4e86e791
Autor:
Boldizsár Czéh, Irina Vardya, Zsófia Varga, Fabia Febbraro, Dávid Csabai, Lena-Sophie Martis, Kristoffer Højgaard, Kim Henningsen, Elena V. Bouzinova, Attila Miseta, Kimmo Jensen, Ove Wiborg
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Clinical and experimental data suggest that fronto-cortical GABAergic deficits contribute to the pathophysiology of major depressive disorder (MDD). To further test this hypothesis, we used a well characterized rat model for depression and examined t
Externí odkaz:
https://doaj.org/article/1f9cec32c8334b099dd1944bec6da17a
Autor:
Camilla Højland Knudsen, Emilía S. Ásgrímsdóttir, Karim Rahimi, Katherine P. Gill, Søs Frandsen, Susanne Hvolbøl Buchholdt, Muwan Chen, Jørgen Kjems, Fabia Febbraro, Mark Denham
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Gene editing in human embryonic stem cells (hESCs) has been significantly enhanced by the discovery and development of CRISPR Cas9, a programmable nuclease system that can introduce targeted double-stranded breaks. The system relies on the optimal se
Externí odkaz:
https://doaj.org/article/fbc93aacf3ab42c1893ea2c5184b5d27
Autor:
Muwan Chen, Sofie H. Laursen, Mette Habekost, Camilla H. Knudsen, Susanne H. Buchholdt, Jinrong Huang, Fengping Xu, Xin Liu, Lars Bolund, Yonglun Luo, Poul Nissen, Fabia Febbraro, Mark Denham
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
The P-type ATPases family consists of ion and lipid transporters. Their unique diversity in function and expression is critical for normal development. In this study we investigated human pluripotent stem cells (hPSC) and different neural progenitor
Externí odkaz:
https://doaj.org/article/75706b549ff94d05b1824beb2b089326
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179434 (2017)
Stress and stressful life events have repeatedly been shown as causally related to depression. The Chronic Mild Stress rat model is a valid model of stress-induced depression. Like humans, rats display great heterogeneity in their response to stress
Externí odkaz:
https://doaj.org/article/af41e2cd05074408bc24c6f9d3e7bdd4
Autor:
Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H. Jensen, Deniz Kirik, Marina Romero-Ramos
Publikováno v:
Neurobiology of Disease, Vol 56, Iss , Pp 47-58 (2013)
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in α-synuclein in a rat model
Externí odkaz:
https://doaj.org/article/d0fadbd0a5e146d188a2e3262299e943