Migration of human T cells can be differentially directed by electric fields depending on the extracellular microenvironment

Autor: Karen Ende, Fabião Santos, Judith Guasch, Ralf Kemkemer

Publikováno v: iScience, Vol 27, Iss 5, Pp 109746- (2024)

Summary: T cell migration plays an essential role in the immune response and T cell-based therapies. It can be modulated by chemical and physical cues such as electric fields (EFs). The mechanisms underlying electrotaxis (cell migration manipulated b

Externí odkaz: https://doaj.org/article/1a66915332eb48c18769195c07bb9649

CCL21-loaded 3D hydrogels for T cell expansion and differentiation

Autor: Imma Ratera, Marc Martínez-Miguel, Jaume Veciana, Xavier Rodriguez Rodriguez, Anna Arís, Elena García-Fruitós, Eduardo Pérez Del Río, Ramon Roca-Pinilla, Judith Guasch, Joachim P. Spatz, Fabião Santos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Biomaterials
IRTA Pubpro. Open Digital Archive
Institut de Recerca i Tecnologia Agroalimentàries (IRTA)

Recent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, there are still many limitations. For example, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefc78190f9cfe54ea50df3b2b24169c
https://doi.org/10.1016/j.biomaterials.2020.120313