Adaptive antibody diversification through N -linked glycosylation of the immunoglobulin variable region

Autor: van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Heer, Pleuni Ooijevaar-de, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb . 115(8), 1901-1906.

Externí odkaz: https://www.jstor.org/stable/26507578

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Differences in IgG autoantibody Fab glycosylation across autoimmune diseases

Autor: Jana Koers, Rocco Sciarrillo, Ninotska I.L. Derksen, Esther M. Vletter, Yvonne E. Fillié-Grijpma, Elisabeth Raveling-Eelsing, Nuno A.G. Graça, Thiemo Leijser, Hendri H. Pas, L. Laura van Nijen-Vos, Maaike V.J. Braham, Anne-Marie Buisman, Jan de Jong, Angela I. Schriek, Anne P. Tio-Gillen, Y.K. Onno Teng, Maurice Steenhuis, Francis H. Swaneveld, Steven W. de Taeye, Marit J. van Gils, Jan J.G.M. Verschuuren, Bram Rutgers, Peter Heeringa, Barbara Horváth, Bart C. Jacobs, Karina de Leeuw, Casper F.M. Franssen, Agnès Veyradier, Paul Coppo, Kyra A. Gelderman, S. Marieke van Ham, Cécile A.C.M. van Els, Diane van der Woude, Ruth Huizinga, Maartje G. Huijbers, Taco W. Kuijpers, Rene E.M. Toes, Nicolaas A. Bos, Theo Rispens

Publikováno v: Journal of Allergy and Clinical Immunology, 151(6), 1646-1654. MOSBY-ELSEVIER
Journal of Allergy and Clinical Immunology, 151(6), 1646-1654. Mosby Inc.
Journal of allergy and clinical immunology, 151(6), 1646-1654. Mosby Inc.
T2B Consortium 2023, ' Differences in IgG autoantibody Fab glycosylation across autoimmune diseases ', Journal of Allergy and Clinical Immunology, vol. 151, no. 6, pp. 1646-1654 . https://doi.org/10.1016/j.jaci.2022.10.035

Background: Increased prevalence of autoantibody Fab glycosylation has been demonstrated for several autoimmune diseases. Objectives: To study whether elevated Fab glycosylation is a common feature of autoimmunity, this study investigated Fab glycosy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5813e3dc93eee892ef693f3c417e2f1
https://research.rug.nl/en/publications/53202de0-8a76-4930-ae74-692d30576434

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Autor: Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Theo Rispens

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains. These Fab glycans are acquired following introduction of N-glycosylation sites during somatic hy

Externí odkaz: https://doaj.org/article/0055da8dc52145e294c840fdd3f67479

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