Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Fa-an Chao"'
Autor:
Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. Among several o
Externí odkaz:
https://doaj.org/article/69321b8535d54b5689b2d175700764dc
Publikováno v:
Magnetic Resonance Letters, Vol 2, Iss 1, Pp 56-58 (2022)
Externí odkaz:
https://doaj.org/article/5c8f1d8ab54c41e3a786e5bbb1eaa9b1
Autor:
Fa-An Chao, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito, Dwight V. Nissley, Frank McCormick, R. Andrew Byrd, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Journal of the American Chemical Society. 144:4196-4205
KRAS is the most frequently mutated RAS protein in cancer patients, and it is estimated that about 20% of the cancer patients in the United States carried mutant RAS proteins. To accelerate therapeutic development, structures and dynamics of RAS prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbe756235a383749eb96cb807417c28
https://doi.org/10.1021/jacs.2c00007
https://doi.org/10.1021/jacs.2c00007
Publikováno v:
J Biomol NMR
Recent methyl adiabatic relaxation dispersion experiments provide examination of conformational dynamics across a very wide timescale (10(2) – 10(5) sec(−1)) and, particularly, provide insight into the hydrophobic core of proteins and allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e3b098d5cb02f25088f0f819aeac49
https://doi.org/10.1007/s10858-020-00312-2
https://doi.org/10.1007/s10858-020-00312-2
Autor:
Olivier Soubias, R. Andrew Byrd, Fa-an Chao, Yue Zhang, Yifei Li, Jess Li, Katherine Shaw, Domarin Khago
Publikováno v:
J Biol Chem
Engineering and bioconjugation of proteins is a critically valuable tool that can facilitate a wide range of biophysical and structural studies. The ability to orthogonally tag or label a domain within a multidomain protein may be complicated by unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ebb45b86b744335468d72eda0ef953
https://doi.org/10.1074/jbc.ra119.012039
https://doi.org/10.1074/jbc.ra119.012039
Theoretical classification of exchange geometries from the perspectives of NMR relaxation dispersion
Publikováno v:
J Magn Reson
NMR relaxation dispersion experiments have been widely applied to probe important conformational exchange of macro-molecules in many biological systems. The current improvements in computational techniques as well as the theoretical breakthroughs mak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5bd00906f68fdbb416c8f56c35f306
https://europepmc.org/articles/PMC8205974/
https://europepmc.org/articles/PMC8205974/
Autor:
Fa An Chao, R. Andrew Byrd
Publikováno v:
Emerg Top Life Sci
Structural biology often focuses primarily on three-dimensional structures of biological macromolecules, deposited in the Protein Data Bank (PDB). This resource is a remarkable entity for the worldwide scientific and medical communities, as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a192386ad55a4662dba0a3a2679b4192
https://pubmed.ncbi.nlm.nih.gov/33241122
https://pubmed.ncbi.nlm.nih.gov/33241122
Publikováno v:
J Am Chem Soc
Methyl-TROSY is one of the most powerful NMR spectroscopic tools for studying structures and conformational dynamics of large protein complexes in solution. In studying conformational dynamics, side chains usually display heterogeneous dynamics, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b74e47b1d926d6e4f444f575578754
https://europepmc.org/articles/PMC7505415/
https://europepmc.org/articles/PMC7505415/
Autor:
R. Andrew Byrd, Fa An Chao
Publikováno v:
Journal of the American Chemical Society. 138:7337-7345
A new computational strategy is reported that provides a fast approximation of numerical solutions of differential equations in general. The method is demonstrated with the analysis of NMR adiabatic relaxation dispersion experiments to reveal biomole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3246918c209ffe4a430b51e0e10e43
https://doi.org/10.1021/jacs.6b02786
https://doi.org/10.1021/jacs.6b02786
Publikováno v:
Journal of Magnetic Resonance. 245:17-23
We present an enhanced version of the FLAMEnGO (Fuzzy Logic Assignment of Methyl Group) software, a structure-based method to assign methyl group resonances in large proteins. FLAMEnGO utilizes a fuzzy logic algorithm coupled with Monte Carlo samplin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29af6313a1241d304c1db5af997af81
https://doi.org/10.1016/j.jmr.2014.04.012
https://doi.org/10.1016/j.jmr.2014.04.012