Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Fa-Xiang Ding"'
Autor:
Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood
Publikováno v:
Circulation.
Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite
Autor:
Xin Gu, Brande Thomas-Fowlkes, Dorothy Levorse, Harry R. Chobanian, Timothy Cutarelli, Alexander Pasternak, Adam B. Weinglass, Ian W. Davies, Martin Koehler, Michael Margulis, Fa-Xiang Ding, Joel B. Yudkovitz, Jinlong Jiang, Haifeng Tang, Lee-Yuh Pai, Barbara Pio, Shuzhi Dong, Mengwei Hu, Kathleen A. Sullivan, Jack Gibson, Thomas Bateman, Koppara Samuel, Xiaoyan Zhou, Caryn Hampton, Reynalda deJesus, Kevin Houle, Emma R. Parmee
Publikováno v:
Journal of medicinal chemistry. 64(11)
A renal outer medullary potassium channel (ROMK, Kir1.1) is a putative drug target for a novel class of diuretics with potential for treating hypertension and heart failure. Our first disclosed clinical ROMK compound, 2 (MK-7145), demonstrated robust
Autor:
Shawn P. Walsh, Lee-Yuh Pai, Yuping Zhu, John P. Felix, Caryn Hampton, Xiaoyan Zhou, Melba Hernandez, Brande Thomas-Fowlkes, Richard M. Brochu, Nardos Teumelsan, Gregory J. Kaczorowski, Emma R. Parmee, Maria L. Garcia, Alexander Pasternak, Jinlong Jiang, Sookhee Ha, Sophie Roy, Kathleen A. Sullivan, Haifeng Tang, Lihu Yang, Karen Owens, Reynalda K. de Jesus, Xin Gu, Birgit T. Priest, Barbara Pio, Fa-Xiang Ding, Andrew M. Swensen, Magdalena Alonso-Galicia, Aurash Shahripour, Juliann Ehrhart, Timothy Bailey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5695-5702
Following the discovery of small molecule acyl piperazine ROMK inhibitors, the acyl octahydropyrazino[2,1-c][1,4]oxazine series was identified. This series displays improved ROMK/hERG selectivity, and as a consequence, the resulting ROMK inhibitors d
Autor:
Fa-Xiang Ding, Sarah Kauffman, Fred Naider, Leah S. Cohen, Katrina E. Fracchiolla, Boris Arshava, Jeffrey M. Becker, Elizabeth Mathew, Mark E. Dumont
Publikováno v:
Biopolymers. 102:16-29
Structural analysis by NMR of G protein-coupled receptors (GPCRs) has proven to be extremely challenging. To reduce the number of peaks in the NMR spectra by segmentally labeling a GPCR, we have developed a Guided Reconstitution method that includes
Publikováno v:
AIDS Research and Human Retroviruses. 29:718-724
Due to the different mechanisms HIV-1 has evolved to escape from a neutralizing antibody response it has been extremely challenging to develop an effective anti-HIV-1 vaccine. The V3 region of the gp120 HIV-1 envelope glycoprotein has been considered
Autor:
Fa-Xiang Ding, Urmi R. Bhatt, Hong C. Shen, Wayne M. Geissler, Judith N. Gorski, Ranabir SinhaRoy, Margarita Garcia-Calvo, Jinlong Jiang, Xinchun Tong, Renee M. Chabin, Beth Ann Murphy, Dong-Ming Shen, Shirly Pinto, Jeffrey J. Hale, Dan Xie, Andreas Verras, Mike E. Lassman, Qing Chen, Suoyu Xu, Judyann Wiltsie, Zhu Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1550-1556
A series of benzodihydroisofurans were discovered as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase (PrCP) inhibitors. The structure–activity relationship (SAR) is focused on improving PrCP activity and metabolic stability,
Autor:
Fa-Xiang Ding, Naama Kessler, Hasmik Sargsyan, Tali Scherf, Eran Noah, Boris Arshava, Fred Naider, Tatsuya Inui, Inbal Ayzenshtat, Jacob Anglister, Einat Schnur, Yael Sagi, Rina Levy
Publikováno v:
Journal of Molecular Biology. 410:778-797
Interaction of CC chemokine receptor 5 (CCR5) with the human immunodeficiency virus type 1 (HIV-1) gp120/CD4 complex involves its amino-terminal domain (Nt-CCR5) and requires sulfation of two to four tyrosine residues in Nt-CCR5. The conformation of
Autor:
Sara M. Connelly, Fa-Xiang Ding, Elizabeth Mathew, Alexander G. Hajduczok, Hasmik Sargsyan, Mark E. Dumont, Anshika Bajaj, Fred Naider
Publikováno v:
Journal of Molecular Biology. 409:513-528
We describe a rapid method to probe for mutations in cell surface ligand-binding proteins that affect the environment of bound ligand. The method uses fluorescence-activated cell sorting to screen randomly mutated receptors for substitutions that alt
Autor:
Urmi R. Bhatt, James R. Tata, Xinchun Tong, Hong C. Shen, Andreas Verras, Renee M. Chabin, Michael E. Lassman, Changyou Zhou, Margarita Garcia-Calvo, J. J. Hale, Ranabir SinhaRoy, Steven L. Colletti, Yusheng Xiong, Dong-Ming Shen, Dunlu Chen, Wayne M. Geissler, Fa-Xiang Ding, Shirly Pinto, Suoyu Xu, Dan Xie, Zhu Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1299-1305
A series of benzimidazole pyrrolidinyl amides containing a piperidinyl group were discovered as novel prolylcarboxypeptidase (PrCP) inhibitors. Low-nanomolar IC(50)'s were achieved for several analogs, of which compound 9b displayed modest ex vivo ta
Autor:
Jeffrey M. Becker, Fred Naider, Li-Yin Huang, Adam R. Farley, Andrew J. Link, Boris Arshava, Fa-Xiang Ding, George K. Essien Umanah
Publikováno v:
Journal of Biological Chemistry. 285:39425-39436
Fundamental knowledge about how G protein-coupled receptors and their ligands interact is important for understanding receptor-ligand binding and the development of new drug discovery strategies. We have used cross-linking and tandem mass spectrometr