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Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

Autor: Razvan L. Cornea, Ching-Chieh Tung, Daniel P. Singh, Filip Van Petegem, Donald M. Bers, Bengt Svensson, Kaja Rožman, Levy M. Treinen, Siobhan M. Wong King Yuen, Courtney C. Aldrich, Bradley S. Launikonis, Jingyan Zhang, David D. Thomas, Aleksey V. Zima, Jacob A. Schwarz, Christopher Y. Ko, Roman Nikolaienko

Publikováno v: The Journal of biological chemistry, vol 298, iss 1
The Journal of Biological Chemistry

The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca2+ release during excitation–contraction (EC) coupling in muscle. The NTR hosts numerous mutations linked to skeletal (RyR1) and cardiac (RyR2) myo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e651b16da8560235f301c406f3eb42
https://escholarship.org/uc/item/1sw1d750

Continuous wave laser diodes enable fast optoacoustic imaging

Autor: Antonios Stylogiannis, George D. Sergiadis, Ludwig Prade, Juan Aguirre, Vasilis Ntziachristos, Andreas Buehler

Publikováno v: Photoacoustics, Vol 9, Iss, Pp 31-38 (2018)
Photoacoustics 9, 31-38 (2018)
Photoacoustics

Pulsed laser diodes may offer a smaller, less expensive alternative to conventional optoacoustic laser sources; however they do not provide pulse rates faster than a few tens of kHz and emit at wavelengths only within the near-infrared region. We inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526381fd1452cdd54d2d21212661a830
http://www.sciencedirect.com/science/article/pii/S2213597917300356

Accurate quantification of lipid species affected by isobaric overlap in Fourier-transform mass spectrometry

Autor: Ralph Burkhardt, Gerhard Liebisch, Christer S. Ejsing, Sabrina Krautbauer, Marcus Höring, Verena M. Ertl

Publikováno v: Journal of Lipid Research, Vol 62, Iss, Pp 100050-(2021)
Höring, M, Ejsing, C S, Krautbauer, S, Ertl, V M, Burkhardt, R & Liebisch, G 2021, ' Accurate quantification of lipid species affected by isobaric overlap in Fourier-transform mass spectrometry ', Journal of Lipid Research, vol. 62, 100050 . https://doi.org/10.1016/j.jlr.2021.100050
Journal of Lipid Research

Lipidomics data require consideration of ions with near-identical masses, which comprises among others the Type-II isotopic overlap. This overlap occurs in series of lipid species differing only by number of double bonds (DBs) mainly because of the n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd7c60b35340106caa9ccd4904c157f
http://www.sciencedirect.com/science/article/pii/S0022227521000304

Interictal pontine metabolism in migraine without aura patients: A 3 Tesla proton magnetic resonance spectroscopy study

Autor: Messoud Ashina, Henrik Larsson, Olaf B. Paulson, Anders Hougaard, Casper Emil Christensen, Samaira Younis, Mark B Vestergaard

Publikováno v: NeuroImage: Clinical, Vol 32, Iss, Pp 102824-(2021)
Younis, S, Hougaard, A, Christensen, C E, Vestergaard, M B, Paulson, O B, Larsson, H B W & Ashina, M 2021, ' Interictal pontine metabolism in migraine without aura patients : A 3 Tesla proton magnetic resonance spectroscopy study ', NeuroImage: Clinical, vol. 32, 102824 . https://doi.org/10.1016/j.nicl.2021.102824
NeuroImage : Clinical

Highlights • Migraine patients were scanned by a 1H-MRS protocol optimized to target the pons. • Measurements were repeated on two separate days to increase accuracy. • Pontine glutamate levels were not increased outside attacks in patients. �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcd54df546f3816aab59c9ed8ab72d9
http://www.sciencedirect.com/science/article/pii/S2213158221002680