The self-reactive FVIII T cell repertoire in healthy individuals relies on a short set of epitopes and public clonotypes

Autor: Valeria Porcheddu, Gautier Lhomme, Rémi Giraudet, Evelyne Correia, Bernard Maillère

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Non-mutated FVIII-specific CD4 T cell epitopes have been recently found to contribute to the development of inhibitors in patients with hemophilia A (HA), while auto-reactive CD4 T cells specific to FVIII circulate in the blood of healthy individuals

Externí odkaz: https://doaj.org/article/73797c65c3b543d0848c1d94104098aa

Exploring the Complex Role of Coagulation Factor VIII in Chronic Liver Disease

Autor: Tomasz W. Kaminski, Tirthadipa Pradhan-Sundd, Shweta Gudapati, Margaret V. Ragni

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1061-1072 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Chronic liver disease is one of the leading causes of death in the United States. Coagulopathy is often a sequela of chronic liver disease, however, the role and regulation of coagulation components in chronic liver injury remain poorly understood. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdbe3852faccdc9807e9be0dea72435
https://doi.org/10.1016/j.jcmgh.2021.02.014

Hemophilia A and C in a female: The first case report in literature

Autor: Jerair Argilo, Mohamad Shadi Alkarrash, Rawad Alkhoury, Mohammad Nour Shashaa, Hala Sallah, Rayan Badawi

Publikováno v: Annals of Medicine and Surgery

Introduction One of the relatively rare hemostatic disorders is coagulation factors' deficiency, where a single factor or multiple factors can be deficient. All hereditary coagulation factors' deficiencies are autosomal recessive, so they can manifes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12874d942438f0fd6cce2d48e054a474
http://europepmc.org/articles/PMC8318996

Long-term efficacy and safety of a pasteurized, plasma-derived factor VIII concentrate (Beriate® P) in patients with haemophilia A

Autor: Saskia Gottstein, Christl Heinrichs, Marija Orlovic, Robert Klamroth

Publikováno v: Thrombosis Research

Introduction Beriate® P was first introduced in Germany in 1990 as factor VIII (FVIII):C® HS Behring and subsequent product improvements yielded an albumin-free formulation with a specific activity of approximately 170 IU/mg protein. In 1992, the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb19fb98b8c546b002e4a90ff6d2355
https://doi.org/10.1016/j.thromres.2013.10.015

Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model.

Autor: Noda M; Department of General Medicine, Nara Medical University, Kashihara, Japan., Tatsumi K; Advanced Medical Science of Thrombosis and Hemostasis, Nara Medical University, Kashihara, Japan., Matsui H; Department of General Medicine, Nara Medical University, Kashihara, Japan., Matsunari Y; Department of Anesthesiology, Nara Medical University, Kashihara, Japan., Sato T; Department of Diagnostic Radiology and IVR, Nara Medical University, Kashihara, Japan., Fukuoka Y; Department of Diagnostic Radiology and IVR, Nara Medical University, Kashihara, Japan., Hotta A; Department of Reprogramming Science, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan., Okano T; Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan., Kichikawa K; Department of Diagnostic Radiology and IVR, Nara Medical University, Kashihara, Japan., Sugimoto M; Department of General Medicine, Nara Medical University, Kashihara, Japan., Shima M; Nara Medical University, Kashihara, Japan., Nishio K; Department of General Medicine, Nara Medical University, Kashihara, Japan.

Publikováno v: Regenerative therapy [Regen Ther] 2021 Sep 10; Vol. 18, pp. 347-354. Date of Electronic Publication: 2021 Sep 10 (Print Publication: 2021).