Zobrazeno 1 - 10
of 170
pro vyhledávání: '"FUTOSHI OKADA"'
Autor:
HeeKyung Seong, Yusuke Kanda, Runa Izutsu, Jumond P. Jehung, Junichi Hamada, Mitsuhiko Osaki, Koji Okamoto, Futoshi Okada
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract AMIGO2 adheres to liver endothelium and induces liver metastasis. We revealed that genetically altering AMIGO2 expression in tumor cells affects their liver metastatic potential, depending on the AMIGO2 expression level. The aim of this stud
Externí odkaz:
https://doaj.org/article/2085d92b19444fadbbed57d64a10acca
Autor:
Masahiro Makinoya, Kozo Miyatani, Yoshiaki Matsumi, Yu Sakano, Shota Shimizu, Yuji Shishido, Takehiko Hanaki, Kyoichi Kihara, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Toshimichi Hasegawa, Hiroaki Saito, Yuji Nakayama, Mitsuhiko Osaki, Futoshi Okada, Yoshiyuki Fujiwara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Intraperitoneal (IP) chemotherapy with paclitaxel (PTX) for gastric cancer (GC) with peritoneal metastasis (PM) is considered a promising treatment approach, however, there are no useful biomarkers to predict the efficacy of IP therapy. We e
Externí odkaz:
https://doaj.org/article/97a461a20ca146be8b96642cf7ce18ea
Autor:
Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B. Lang, Tomohiro Nakamura, Kam Y. J. Zhang, Stuart A. Lipton, Takashi Uehara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic co
Externí odkaz:
https://doaj.org/article/2948479591604774a634757fd4634fae
Autor:
Keisuke Goto, Masaki Morimoto, Mitsuhiko Osaki, Akimitsu Tanio, Runa Izutsu, Yoshiyuki Fujiwara, Futoshi Okada
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Gastric cancer (GC) is one of the most common malignancies, and the liver is the most common site of hematogenous metastasis of GC. AMIGO2 is a type I transmembrane protein that has been implicated in tumour cell adhesion in adeno
Externí odkaz:
https://doaj.org/article/bb21c97bf2804fd18632c3ba814eb339
Autor:
Runa Izutsu, Mitsuhiko Osaki, Hideyuki Nemoto, Maho Jingu, Ryo Sasaki, Yusuke Yoshioka, Takahiro Ochiya, Futoshi Okada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Adhesion of cancer cells to vascular endothelial cells in target organs is an initial step in cancer metastasis. Our previous studies revealed that amphoterin-induced gene and open reading frame 2 (AMIGO2) promotes the adhesion of tumor cell
Externí odkaz:
https://doaj.org/article/1509bab1dc384ccc9a3082ae31e6f644
Autor:
Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara, Futoshi Okada
Publikováno v:
Diagnostic Pathology, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Instruction The human amphoterin-induced gene and open reading frame (AMIGO) was identified as a novel cell adhesion molecule of type I transmembrane protein. AMIGO2 is one of three members of the AMIGO family (AMIGO1, 2, and 3), and the sim
Externí odkaz:
https://doaj.org/article/9ad41b48f36f47758a608cc7a4b8266f
Autor:
Hideyuki Nemoto, Marina Otake, Takahiro Matsumoto, Runa Izutsu, Jumond P Jehung, Keisuke Goto, Mitsuhiko Osaki, Masafumi Mayama, Masataka Shikanai, Hiroshi Kobayashi, Tetsushi Watanabe, Futoshi Okada
Publikováno v:
Journal of Functional Foods, Vol 88, Iss , Pp 104907- (2022)
Fermented brown rice and rice bran with Aspergillus oryzae (FBRA) has shown chemopreventive effectiveness against inflammation-related carcinogenesis, by inhibiting inflammation. We found that Aspergillus oryzae is the main component of the anti-infl
Externí odkaz:
https://doaj.org/article/6de46323592143eb92f091e4e871540a
Publikováno v:
Genes and Environment, Vol 40, Iss 1, Pp 1-8 (2018)
Abstract Background Experimental and controlled human exposure studies have demonstrated additive effects of ambient particulate matter and ozone on health. A few epidemiological studies have suggested that ambient particulate matter components are i
Externí odkaz:
https://doaj.org/article/ab3037f64f6b4e3a9138d420603b3bcb
Autor:
Yusuke Kimura, Masashi Honda, Ryo Sasaki, Tetsuya Yumioka, Hideto Iwamoto, Panagiota Tsounapi, Shuichi Morizane, Katsuya Hikita, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227321 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0220381.].
Externí odkaz:
https://doaj.org/article/5b8a6f0af8174c4e8cfc66a1ab79f55d
Autor:
Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Sayaka Aoki, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0217605 (2019)
Telomerase is a ribonucleoprotein ribonucleic enzyme that is essential for cellular immortalization via elongation of telomere repeat sequences at the end of chromosomes. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of telome
Externí odkaz:
https://doaj.org/article/ae0eafbb777743f0b6ccad79149212d0