Zobrazeno 1 - 10
of 286
pro vyhledávání: '"FSP1"'
Autor:
Xiaoqian Tan, Yinling He, Panpan Yu, Yunong Deng, Zhongcheng Xie, Jiami Guo, Qin Hou, Pin Li, Xiaoyan Lin, Siyu Ouyang, Wentao Ma, Yushu Xie, Zilong Guo, Dandan Chen, Zhixia Zhang, Yunyu Zhu, Fei Huang, Ziye Zhao, Cen Zhang, Zhirong Guo, Xi Chen, Tianhong Peng, Liang Li, Wei Xie
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-27 (2024)
Abstract Background Acute monocytic leukemia-M5 (AML-M5) remains a challenging disease due to its high morbidity and poor prognosis. In addition to the evidence mentioned earlier, several studies have shown that programmed cell death (PCD) serves a c
Externí odkaz:
https://doaj.org/article/b9728a26a3f1429693df582dc1fd9d33
Autor:
Hongliang Qiu, Sihui Huang, Yuting Liu, Libo Liu, Fengming Guo, Yingying Guo, Dan Li, Xianfeng Cen, Yajie Chen, Meng Zhang, Yan Che, Man Xu, Qizhu Tang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2581-2597 (2024)
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenon
Externí odkaz:
https://doaj.org/article/dfe8996f856d4f6dbc399a77398b3539
Autor:
Xuelian Chen, Jizhuang Wang, Peilang Yang, Hsin-Ying Liu, Shan Zhong, Chenghao Lu, Min Gao, Dan Liu, Jie Zhang, Jiaqiang Wang, Shan Ma, Wenao Wang, Hanting Zhu, Xiong Zhang, Yan Liu
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103267- (2024)
Ferroptosis, driven by an imbalance in redox homeostasis, has recently been identified to regulate macrophage function and inflammatory responses. SENP3 is a redox-sensitive de-SUMOylation protease that plays an important role in macrophage function.
Externí odkaz:
https://doaj.org/article/8804cb87c0794cf5b794db75b8f2a29a
Autor:
Chenyang Fan, Xiaohong Guo, Jie Zhang, Wen Zheng, Chonglin Shi, Yongwei Qin, Haoliang Shen, Yang Lu, Yihui Fan, Yanli Li, Liuting Chen, Renfang Mao
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Ferroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and a promising target for cancer therapeutics. However, the role of
Externí odkaz:
https://doaj.org/article/5372388f4d7543909a3004da3d6d5839
Autor:
Cheng Qiu, Lin Cheng, Derun Di, Ziqian Xiang, Congyu Wang, Jinghang Li, Yinuo Xiong, Manyu Li, Jingwei Liu, Jian Zhou, Tianyi Liu, Xinyu Wang, Dan Luo, Xiaoxiong Wang, Shangye Li, Hui Wang, Xia Wang, Yunpeng Zhao, Xinyu Liu, Lianlei Wang
Publikováno v:
Genes and Diseases, Vol 12, Iss 1, Pp 101251- (2025)
Intervertebral disc degeneration (IDD) is a common chronic inflammatory degenerative disease that causes lower back pain. However, the underlying mechanisms of IDD remain unclear. Ferroptosis suppressor protein 1 (FSP1) is a newly identified suppress
Externí odkaz:
https://doaj.org/article/1d6bf7c678414e0d9943e435e86f0f56
Autor:
Na Liu, Wei-Long Wu, Xiao-Rui Wan, Jing Wang, Jia-Ni Huang, Yi-Yue Jiang, Yi-Chao Sheng, Jun-Chao Wu, Zhong-Qin Liang, Zheng-Hong Qin, Yan Wang
Publikováno v:
Redox Biology, Vol 73, Iss , Pp 103176- (2024)
Excitotoxicity is a prevalent pathological event in neurodegenerative diseases. The involvement of ferroptosis in the pathogenesis of excitotoxicity remains elusive. Transcriptome analysis has revealed that cytoplasmic reduced nicotinamide adenine di
Externí odkaz:
https://doaj.org/article/3c3de55a7f404d049347076c2d826fcc
Autor:
Yixin Ma, Lili Huang, Zheng Zhang, Pengfei Yang, Qingsong Chen, Xujia Zeng, Fangyan Tan, Chunxia Wang, Xiongzhong Ruan, Xiaohui Liao
Publikováno v:
Genes and Diseases, Vol 11, Iss 1, Pp 449-463 (2024)
Reactive oxidative species (ROS) production-driven ferroptosis plays a role in acute kidney injury (AKI). However, its exact molecular mechanism is poorly understood. Scavenger receptor CD36 has important roles in oxidizing lipids, lipid accumulation
Externí odkaz:
https://doaj.org/article/94220db65fb34071b3a21cec0e9644f9
Autor:
Shijian Feng, Xiaofang Huang, Dan Tang, Xiaoyu Liu, Liang Ouyang, Dehua Yang, Kunjie Wang, Banghua Liao, Shiqian Qi
Publikováno v:
MedComm, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Ferroptosis is a recently discovered form of regulated cell death characterized by its distinct dependence on iron and the peroxidation of lipids within cellular membranes. Ferroptosis plays a crucial role in physiological and pathological s
Externí odkaz:
https://doaj.org/article/126bd950894f4f48b7cc62b1285a2677
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 871 (2024)
Background: Hepatocellular carcinoma (HCC), currently ranking as the third most lethal malignancy, poses a grave threat to human health. Ferroptosis, a form of programmed cell demise, has emerged as a promising therapeutic target in HCC treatment. In
Externí odkaz:
https://doaj.org/article/fa6aa43954964690ad725264130b3abf
Autor:
Yongpan Lu, Dejie Zhao, Ming Liu, Guoqi Cao, Chunyan Liu, Siyuan Yin, Ru Song, Jiaxu Ma, Rui Sun, Zhenjie Wu, Jian Liu, Yibing Wang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objective: Gongying-Jiedu-Xiji recipe (DDL, batch number Z01080175) reduces body temperature, detoxifies, activates the blood circulation, reduces swelling, and dispels decay and pus. The aim of this study was to investigate the mechanism of action b
Externí odkaz:
https://doaj.org/article/2fbdf617b5fb443ab4f986369db64160