Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury

Autor: Natacha Bohin, Kelley S. Yan, Elizabeth A. Carlson, Linda C. Samuelson, Kevin P. McGowan, Theresa M. Keeley

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 797-810 (2020)

Background & Aims Intestinal crypts have a remarkable capacity to regenerate after injury from loss of crypt base columnar (CBC) stem cells. After injury, facultative stem cells (FSCs) are activated to replenish the epithelium and replace lost CBCs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c6791d3ccce273838e7db42e05a6de
https://pubmed.ncbi.nlm.nih.gov/32791156