INIBIÇÃO DA VIA HGF/MET NO NICHO DA MEDULA ÓSSEA REPRESENTA POTENCIAL ALVO TERAPÊUTICO PARA LEUCEMIA MIELOIDE AGUDA

Autor: MLP Bueno, FS Niemann, NG Amôr, I Santos, ASS Duarte, A Bastos, STO Saad, FM Roversi

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S346- (2024)

Objetivos: O fator de crescimento de hepatócitos (HGF) é um mitógeno secretado por células estromais mesenquimais (MSCs) que regula o crescimento, a motilidade e a morfogênese celular. No microambiente tumoral da medula óssea (MO) (nicho), o HG

Externí odkaz: https://doaj.org/article/063d44e101b84ad6b8620fe0cce30ebb

PIM447, NOVO INIBIDOR DE PROTEÍNAS PAN-PIM QUINASES, TEM MÚLTIPLOS EFEITOS NA LEUCEMIA MIELOIDE AGUDA ATRAVÉS DA VIA HGF

Autor: FM Roversi, MLP Bueno, FS Niemann, I Santos, NG Amôr, ADS Santos, A Bastos, STO Saad

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S238- (2023)

Objetivos: PIM-quinases, associadas à progressão de cânceres induzidos pelo fator de crescimento de hepatócitos (HGF) por meio de seu receptor, MET, interagem com a serina protease tipo kunitz-2 (SPINT2), no microambiente tumoral (TME) e sua inte

Externí odkaz: https://doaj.org/article/67f55ca0b14a4088982d3e7805fc06fe

NOCAUTE DO GENE BETA-2 MICROGLOBULINA EM CÉLULAS DERIVADAS DO TECIDO ADIPOSO UTILIZANDO O SISTEMA CRISPR/CAS9 PARA A GERAÇÃO DE PLAQUETAS HLA CLASSE I UNIVERSAIS

Autor: LF Catelli, MAF Corat, FS Niemann, AS Santos, NG Amôr, IPF Santos, FBS Teófilo, PSD Santos, STO Saad

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 45, Iss , Pp S757-S758 (2023)

A refratariedade é um problema recorrente no tratamento de pacientes trombocitopênicos que impede a restauração dos níveis normais de plaquetas circulantes após transfusões. Sua principal causa é a incompatibilidade entre os antígenos HLA Cl

Externí odkaz: https://doaj.org/article/b9cf0f2b1b63497e847d4c988c05120a

Prognostic implications of ΔNp73/TAp73 expression ratio in core-binding factor acute myeloid leukemia.

Autor: Salustiano-Bandeira ML; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Moreira-Aguiar A; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Pereira-Martins DA; Department of Genetics, Federal University of Pernambuco, Recife, Brazil.; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Coelho-Silva JL; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Weinhäuser I; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., França-Neto PL; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Lima AS; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Lima AS; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., Baccarin AR; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., Silva FB; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., de Melo MA; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., Niemann FS; Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Brazil., Nardinelli L; Hematology Division, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Ortiz Rojas CA; Hematology Division, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Duarte BK; Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Brazil.; Department of Internal Medicine, University of Campinas, Campinas, Brazil., Araujo AS; Department of Internal Medicine, Hematology and Hemotherapy Foundation of Pernambuco, Recife, Brazil., Azevedo EA; Department of Virology, Fundação Oswaldo Cruz, Instituto de Pesquisas Aggeu Magalhães, Recife, Brazil., Morais CN; Department of Virology, Fundação Oswaldo Cruz, Instituto de Pesquisas Aggeu Magalhães, Recife, Brazil., Figueiredo-Pontes LL; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., Schuringa JJ; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Huls G; Department of Hematology, Cancer Research Centre Groningen, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Bendit I; Hematology Division, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Rego EM; Hematology Division, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil., Olalla Saad ST; Hematology and Transfusion Medicine Center, University of Campinas, Campinas, Brazil.; Department of Internal Medicine, University of Campinas, Campinas, Brazil., Traina F; Department of Medical Imaging, Hematology, and Oncology, Medical School of Ribeirao Preto, University of São Paulo, Ribeirao Preto, Brazil., Bezerra MA; Department of Genetics, Federal University of Pernambuco, Recife, Brazil., Lucena-Araujo AR; Department of Genetics, Federal University of Pernambuco, Recife, Brazil. antonio.araujo@ufpe.br.

Publikováno v: Blood cancer journal [Blood Cancer J] 2024 Jun 24; Vol. 14 (1), pp. 102. Date of Electronic Publication: 2024 Jun 24.

Artemisinins induce endoplasmic reticulum stress in acute leukaemia cells in vitro and in vivo.

Autor: Mancuso RI; Haematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Azambuja JH; Haematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Niemann FS; Haematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Congrains A; Haematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Foglio MA; Faculty of Pharmaceutical Science University of Campinas Campinas Brazil., Rego EM; Center for Cell Based Therapy University of São Paulo Ribeirão Preto Brazil.; Haematology Division, LIM31, Faculdade de Medicina University of São Paulo São Paulo Brazil., Olalla Saad ST; Haematology and Transfusion Medicine Center University of Campinas Campinas Brazil.

Publikováno v: EJHaem [EJHaem] 2021 Oct 16; Vol. 2 (4), pp. 818-822. Date of Electronic Publication: 2021 Oct 16 (Print Publication: 2021).