New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline Derivatives: Synthesis and Biological Evaluation as Novel Anticancer Agents by Targeting G-Quadruplex

Autor: Jean Guillon, Marc Le Borgne, Vittoria Milano, Aurore Guédin-Beaurepaire, Stéphane Moreau, Noël Pinaud, Luisa Ronga, Solène Savrimoutou, Sandra Albenque-Rubio, Mathieu Marchivie, Haouraa Kalout, Charley Walker, Louise Chevallier, Corinne Buré, Eric Largy, Valérie Gabelica, Jean-Louis Mergny, Virginie Baylot, Jacky Ferrer, Yamina Idrissi, Edith Chevret, David Cappellen, Vanessa Desplat, Zsuzsanna Schelz, István Zupkó

Publikováno v: Pharmaceuticals, Vol 17, Iss 1, p 30 (2023)

The syntheses of novel 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazolines 12 and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinolines 13 are reported here in six steps starting from various halogeno-quinazoline-2,4-(1H,3H)-diones or subst

Externí odkaz: https://doaj.org/article/a1792b25a47e4834a049e8058f8ad1b4

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Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding

Autor: Filippo Doria, Valentina Pirota, Michele Petenzi, Marie-Paule Teulade-Fichou, Daniela Verga, Mauro Freccero

Publikováno v: Molecules, Vol 23, Iss 9, p 2162 (2018)

Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl polyoxazoles and polyoxadiazoles were recently identified as selective G-quadruplex stabilizing compounds with hig

Externí odkaz: https://doaj.org/article/cbe4c53f58154394bd955ecd5829c816

Probing GFP Chromophore Analogs as Anti-HIV Agents Targeting LTR-III G-Quadruplex

Autor: Polina V. Kovalets, Dmitriy Yu. Ryazantsev, Mikhail Yu. Myshkin, Mikhail S. Baranov, Andrey V. Aralov, Timofei S. Zatsepin, Nadezhda S. Baleeva, Zakhar O. Shenkarev, Elvira R. Zaitseva, Elena Y. Shustova, Vladimir B. Tsvetkov, Liubov I. Kozlovskaya, Vera A. Alferova, Polina N. Kamzeeva

Publikováno v: Biomolecules, Vol 11, Iss 1409, p 1409 (2021)
Biomolecules
Volume 11
Issue 10

Green fluorescent protein (GFP) chromophore and its congeners draw significant attention mostly for bioimaging purposes. In this work we probed these compounds as antiviral agents. We have chosen LTR-III DNA G4, the major G-quadruplex (G4) present in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03267323182472362811e6679c2519b9
https://www.mdpi.com/2218-273X/11/10/1409

Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex

Autor: Sandra Rubio, Jean Guillon, Solène Savrimoutou, Marie-Claude Viaud-Massuard, Jean-Louis Mergny, Luisa Ronga, Eric Largy, Matthieu Ranz, Marie Brachet-Botineau, Frédéric Rosu, Jacky Ferrer, Jeremy Lamarche, Fabrice Gouilleux, Valérie Gabelica, Vittoria Milano, Aurore Guédin-Beaurepaire, Edith Chevret, Vanessa Desplat, Caroline Denevault-Sabourin, Stéphane Moreau

Publikováno v: Archiv der Pharmazie / Chemistry in Life Sciences
Archiv der Pharmazie / Chemistry in Life Sciences, Wiley-VCH Verlag, In press, ⟨10.1002/ardp.202000450⟩
Archiv der Pharmazie / Chemistry in Life Sciences, 2021, 354, pp.e2000450. ⟨10.1002/ardp.202000450⟩

International audience; Current multiagent chemotherapy regimens have improved the cure rate in acute leukemia patients, but they are highly toxic and poorly efficient in relapsed patients. To improve the treatment approaches, new specific molecules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccebe3fb18cf78eb441ad102fa32a0d
https://pubmed.ncbi.nlm.nih.gov/33852185