Zobrazeno 1 - 10
of 74
pro vyhledávání: '"FRANZ THEURING"'
Autor:
Karima Schwab, Mandy Magbagbeolu, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The accumulation of α-synuclein (α-Syn) into Lewy bodies is a hallmark of synucleinopathies, a group of neurological disorders that include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Small oligomers as well as larger f
Externí odkaz:
https://doaj.org/article/1ad118a61c2b453db472d785f41f7ed3
Autor:
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110955- (2024)
In clinical trials for Alzheimer’s disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as m
Externí odkaz:
https://doaj.org/article/55dcde6ffee8464392a774ea753330c1
Autor:
Karima Schwab, Valeria Melis, Charles R. Harrington, Claude M. Wischik, Mandy Magbagbeolu, Franz Theuring, Gernot Riedel
Publikováno v:
Cells, Vol 10, Iss 8, p 2162 (2021)
Abnormal aggregation of tau is the pathological hallmark of tauopathies including frontotemporal dementia (FTD). We have generated tau-transgenic mice that express the aggregation-prone P301S human tau (line 66). These mice present with early-onset,
Externí odkaz:
https://doaj.org/article/b2500fa0bdfa475ebc7bdc4d30a9d076
Autor:
Karima Schwab, Silke Frahm, David Horsley, Janet E. Rickard, Valeria Melis, Elizabeth A. Goatman, Mandy Magbagbeolu, Morag Douglas, Michael G. Leith, Thomas C. Baddeley, John M. D. Storey, Gernot Riedel, Claude M. Wischik, Charles R. Harrington, Franz Theuring
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2018)
α-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson’s disease (PD). We have tested whether N,N,N′,N′-tetramethyl-10H-phenothiazine-3,7-diaminium bis(hydromethanesu
Externí odkaz:
https://doaj.org/article/0870bfe813ae4775a7bd84f78b74cbf3
Autor:
Nadir Gül, Franz Theuring
Publikováno v:
Experimed. :120-129
Objective: Alongside its role as a potent vasoconstrictor in the cardiovascular system, endothelin-1 (ET-1) is involved in numerous physiological processes. Its expression is thought to be an important function for both breastfeeding and newborns sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c156c52ac46370c1471f6f13333149e3
https://doi.org/10.26650/experimed.2021.864772
https://doi.org/10.26650/experimed.2021.864772
Autor:
Gernot Riedel, Karima Schwab, Charles R. Harrington, Nora Lemke, Claude M. Wischik, Franz Theuring, Boris Neumann, Dilyara Lauer, Mandy Magbagbeolu, Valeria Melis
Publikováno v:
The Journal of Biological Chemistry
Synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as Alzheimer's disease and frontotemporal dementia. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4f3a5086da2a4a11bb398202f19df8
http://europepmc.org/articles/PMC7939472
http://europepmc.org/articles/PMC7939472
Autor:
Renato X. Santos, Dilyara Lauer, Mandy Magbagbeolu, Constantin Kondak, Franz Theuring, Karima Schwab, Marta Steczkowska, Maciej Zadrozny, Malgorzata Wydrych, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Anna Cranston, Grazyna Niewiadomska, Jochen Klein, Valeria Melis
Publikováno v:
Current Alzheimer Research
Background: Symptomatic treatments of Alzheimer’s Disease (AD) with cholinesterase inhibitors and/or memantine are relatively ineffective and there is a need for new treatments targeting the underlying pathology of AD. In most of the failed disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d6a2554e6d21aa1d5fe5a69a8cf746
https://doi.org/10.2174/1567205017666200224120926
https://doi.org/10.2174/1567205017666200224120926
Autor:
Karima Schwab, Zoi Chasapopoulou, Silke Frahm, Mandy Magbagbeolu, Anna Cranston, Charles R. Harrington, Claude M. Wischik, Franz Theuring, Gernot Riedel
Publikováno v:
Cellular Signalling. 97:110386
The accumulation of alpha-synuclein (α-Syn) into Lewy bodies in cortical and subcortical regions has been linked to the pathogenesis of synucleinopathies such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB). While there is a strong l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92fecb5e4c6d240e099196ac2570a7a
https://doi.org/10.1016/j.cellsig.2022.110386
https://doi.org/10.1016/j.cellsig.2022.110386
Autor:
Nadir Gül, Franz Theuring
Publikováno v:
Volume: 11, Issue: 1 1-11
Experimed
Experimed
Objective: As a distinct cellular signaling model, a receptor cross-talk between G protein-coupled receptors (GPCR) and epidermal growth factor receptor (EGFR) has been demonstrated in various in vitro studies. In addition, recent in vitro studies ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127bc155651c85e5169707d11187dd69
https://dergipark.org.tr/tr/pub/experimed/issue/62231/864886
https://dergipark.org.tr/tr/pub/experimed/issue/62231/864886
Autor:
Bettina Platt, Jochen Vogl, Nikolay Solovyev, Karima Schwab, Franz Theuring, Elizabeth Griffin, Frank Vanhaecke, Andrea Raab, Marta Costas-Rodríguez, Ahmed H. El-Khatib
Publikováno v:
The Journal of Biological Chemistry
JOURNAL OF BIOLOGICAL CHEMISTRY
JOURNAL OF BIOLOGICAL CHEMISTRY
Alzheimer’s disease (AD) is characterized by accumulation of tau and amyloid-beta in the brain, and recent evidence suggests a correlation between associated protein aggregates and trace elements, such as copper, iron, and zinc. In AD, a distorted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17246254d5ee9ebbd7fa8a442af2e873
http://europepmc.org/articles/PMC7949056
http://europepmc.org/articles/PMC7949056