Výsledky vyhledávání - "FRANSSEN, EJF"

Valproic acid toxicokinetics: Serial hemodialysis and hemoperfusion

Autor: Franssen, EJF, van Essen, GG, Portman, AT, Go, G, Stegeman, CA, Uges, DRA

Publikováno v: Therapeutic Drug Monitoring, 21(3), 289-292. LIPPINCOTT WILLIAMS & WILKINS

The toxicity and pharmacokinetic properties of a drug determine whether hemodialysis and/or hemoperfusion are indicated in acute intoxications. Valproic acid is considered unremovable by hemodialysis because of the high protein binding of 90%-95%. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::b7e98f3cec565c8c334e4f3e3fb35589
https://research.rug.nl/en/publications/9bf420dd-f5ff-4a80-99e7-63095fb04698

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A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier

Autor: Hendrikse, NH, de Vries, EGE, Eriks-Fluks, L, van der Graaf, WTA, Hospers, GAP, Willemsen, ATM, Vaalburg, W, Franssen, EJF

Publikováno v: Cancer Research, 59(10), 2411-2416. AMER ASSOC CANCER RESEARCH

Drug resistance is a major cause of chemotherapy failure in cancer treatment, One reason is the overexpression of the drug efflux pump P-glycoprotein (P-gp), involved in multidrug resistance (MDR), In vivo pharmacokinetic analysis of P-gp transport m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::0ceb937b4c85fca70a825d93cf90f668
https://research.rug.nl/en/publications/28050621-ffa6-4f3a-a4a9-41965440bdaf

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Tc-99m-Sestamibi scanning with SDZ PSC 833 as a functional detection method for resistance modulation in patients with solid tumours

Autor: Bakker, M, Van der Graaf, WTA, Piers, DA, Franssen, EJF, Groen, HJM, Smit, EF, Kool, W, Hollema, H, Muller, EA, de Vries, EGE

Publikováno v: Anticancer Research, 19(3B), 2349-2353. INT INST ANTICANCER RESEARCH

Background: Our aim was to determine the value of 99mTc-Sestamibi scanning as functional detection method of P-glycoprotein (Pgp) blockade by PSC 833 in solid tumour patients. Patients and methods: Day 1 and day 4 after 2,200 mg orally administered P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4963b4a91a373bafee05d592c8a70692
https://research.rug.nl/en/publications/2b161979-6ed6-42fc-ac0e-35b8e6150ff6

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Feasibility of tumor imaging using L-3-[iodine-123]-iodo-alpha-methyl-tyrosine in extracranial tumors

Autor: Jager, PL, Franssen, EJF, Kool, W, Szabo, BG, Hoekstra, HJ, Groen, HJM, de Vries, EGE, van Imhoff, GW, Vaalburg, W, Piers, DA

Publikováno v: Journal of Nuclear Medicine, 39(10), 1736-1743. SOC NUCLEAR MEDICINE INC

L-3-[I-123]-lodo-alpha-methyl-tyrosine (IMT) is a modified amino acid. It is reported to be avidly taken up in brain tumors, reflecting amino acid transport and is suitable for SPECT. Methods: To determine whether tumors outside the brain can also ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::5e54a8a4db218b7539d273a727d19767
https://research.rug.nl/en/publications/5d6ce4b1-3997-4cac-b045-44fb724ed0f5

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Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

Autor: Hendrikse, NH, Schinkel, AH, De Vries, EGE, Fluks, E, Van der Graaf, WTA, Willemsen, ATM, Vaalburg, W, Franssen, EJF

Publikováno v: British Journal of Pharmacology, 124(7), 1413-1418. Wiley-Blackwell

1 Homozygously mdr1a gene disrupted mice (mdr1a(-/-) mice) and wild type mice (mdr1a(+/+) mice) were used to develop a method for P-glycoprotein (P-gp) function imaging non-invasively and to study the effect of a P-gp reversal agent on its function i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::080f029061624e863b8119936a5a0151
https://research.rug.nl/en/publications/c65f61ef-23f5-4275-b6d2-8e3e1c00d7ba

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Enzymatic synthesis of [4-methoxy-C-11]daunorubicin for functional imaging of P-glycoprotein with PET

Autor: Eriks-Fluks, E, Elsinga, PH, Hendrikse, NH, Franssen, EJF, Vaalburg, W

Publikováno v: Applied Radiation and Isotopes, 49(7), 811-813. PERGAMON-ELSEVIER SCIENCE LTD

One of the mechanisms for multidrug resistance (MDR) of tumors is an overexpression of the P-glycoprotein (P-gp). The cytostatic agent daunorubicin was labeled with carbon-11 to probe P-gp with PET. An enzymatic route for the conversion of carminomyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ceba919bb99d9efbe3882f6e9ebdc4d8
https://research.rug.nl/en/publications/97f3907b-082f-40b6-9aa9-eaa98e90766d

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Measurement of free fatty acid kinetics during non-equilibrium tracer conditions in man: implications for the estimation of the rate of appearance of free fatty acids

Autor: Riemens, SC, Dullaart, RPF, Franssen, EJF, Piers, DA, Sluiter, WJ

Publikováno v: European Journal of Clinical Investigation, 28(2), 108-114. Wiley

Background This study aimed to document the applicability and variability of free fatty acid (FFA) kinetic parameters during non-equilibrium and equilibrium tracer conditions in man. Methods FFA kinetic parameters were assessed after an overnight fas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cc4a1164d865905f93ecdd7987031f0f
https://research.rug.nl/en/publications/58b27ef2-eab6-47fb-8b49-5a497b931491

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Cobalt-55 positron emission tomography in ischemic stroke

Autor: Jansen, HML, Paans, AMJ, Vliet, AMV, VeenmavanderDuin, L, BolwijnMeijer, CJW, Pruim, J, Willemsen, ATM, Franssen, EJF, Minderhoud, JM, Korf, J

Publikováno v: Clinical neurology and neurosurgery, 99(1), 6-10. ELSEVIER SCIENCE BV

After acute cerebral stroke, the (peri-) infarct tissue is characterized by calcium (Ca)-mediated neuronal damage and inflammatory processes. Monitoring Ca-mediated damage using the isotope cobalt-55 (Go) as a Ga-tracer may enable PET-imaging of this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7e0d4f03fb73aadc96b9233316ab117b
https://research.rug.nl/en/publications/7ddda78e-15f5-4b70-b8e0-9e61a48d6253

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Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET

Autor: Elsinga, PH, Franssen, EJF, Hendrikse, NH, Fluks, L, Weemaes, AMA, vanderGraaf, WTA, deVries, GE, Visser, GM, Vaalburg, W

Publikováno v: Journal of Nuclear Medicine, 37(9), 1571-1575. SOC NUCLEAR MEDICINE INC

One of the mechanisms for multidrug resistance (MDR) of tumors is an overexpression of the P-glycoprotein (P-gp). The cytostatic agent daunorubicin and the modulator verapamil were labeled with C-11 to probe P-gp with PET. Methods: Carbon-11-daunorub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::a5f1417766f8fbff2433802cfc5c24d5
https://research.rug.nl/en/publications/8304e2fd-1184-4764-bec6-9e533ad96d39

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COBALT-55 POSITRON EMISSION TOMOGRAPHY IN RELAPSING-PROGRESSIVE MULTIPLE-SCLEROSIS

Autor: JANSEN, HML, WILLEMSEN, ATM, SINNIGE, LGF, PAANS, AMJ, HEW, JM, FRANSSEN, EJF, ZORGDRAGER, AM, PRUIM, J, MINDERHOUD, JM, KORF, J

Publikováno v: JOURNAL OF THE NEUROLOGICAL SCIENCES, 132(2), 139-145. ELSEVIER SCIENCE BV

Multiple sclerosis (MS) is an immune-mediated disease of the white matter in the brain that can have a progressive course. However, the progression of relapsing-remitting (RR) MS into relapsing-progressive (RP) MS might represent a more fundamental c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::34dd5885826eaa9fa0070caf00cb91b9
https://research.rug.nl/en/publications/474faeb4-4d91-4d5c-b1e0-6fbf07dda19a

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