Zobrazeno 1 - 10
of 206
pro vyhledávání: '"FRANK L. GRAHAM"'
Publikováno v:
BioTechniques, Vol 29, Iss 3, Pp 524-528 (2000)
We have recently developed a high-efficiency method of constructing adenovirus vectors based on Cre-mediated recombination between two plasmids co-transfected into 293 cells. The simplicity and efficiency of this method should greatly expedite the co
Externí odkaz:
https://doaj.org/article/a074403a8a67416bb125ef9ad0f6ee7a
Evidence has been presented that herpes simplex virus (HSV) immunoglobulin (IgG) Fc receptors are composed of a complex of two glycoproteins, gE and gI. In previous studies, cells infected with HSV-1 mutants lacking either gE or gI bound lower levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22b8414ddc2add6a29233d1326b3a9b
https://doi.org/10.1016/0042-6822(90)90507-n
https://doi.org/10.1016/0042-6822(90)90507-n
Autor:
Sheena H. MacLeod, Frank L. Graham, K Agopsowicz, Uma Sankar, Gianluca Bossi, Mary Hitt, M M Elgadi, David Sharon, A Pisio
Publikováno v:
Cancer Gene Therapy. 19:888-898
Despite the tremendous potential of adenovirus (Ad) as a delivery vector for cancer gene therapy, its use in clinical settings has been limited, mainly as a result of the limited infectivity in many tumors and the wide tissue tropism associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff2dca9cb00ae207b846548f2d4f946
https://doi.org/10.1038/cgt.2012.79
https://doi.org/10.1038/cgt.2012.79
Autor:
Todd A. Braciak, Yaiza Diaz de Durana, J Gauldie, Claudia Raja Gabaglia, Eli E. Sercarz, Frank L. Graham
Publikováno v:
Cancer Research. 67:2290-2297
Tumor cells can evolve to evade immune responses by down-modulating surface MHC class I expression and become refractory to T cell–directed immunotherapy. We employed a strategy to bypass this escape mechanism using a recombinant adenovirus vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668fd2ee31c8004bbb36821b5fccfab7
https://doi.org/10.1158/0008-5472.can-06-3399
https://doi.org/10.1158/0008-5472.can-06-3399
Publikováno v:
Annals of the New York Academy of Sciences. 762:282-293
Recombinant Adenovirus type 5 constructs containing IL-6 cDNA can be used to infect cells in vitro and obtain a high level of IL-6 expression and secretion into culture media. Furthermore, Ad5-IL-6 viruses can also be used to infect Balb/c mice or Sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03560154c6d5f6d430a9423967949049
https://doi.org/10.1111/j.1749-6632.1995.tb32333.x
https://doi.org/10.1111/j.1749-6632.1995.tb32333.x
Autor:
B. Brett Finlay, Lois A. Zitzow, James M. Rini, Aubrey J. Tingle, David Lawrence, David M. Patrick, Lorne A. Babiuk, Chetna Sharon, Raymond H. See, Jack Gauldie, Robert J. Hogan, Mary Hitt, Catherine P. Y. Mok, James B. Mahony, Alexander N. Zakhartchouk, David W. Scheifele, Frank L. Graham, Thomas Rowe, Thierry C. Auperin, Rachel L. Roper, Karuna P. Karunakaran, Ludvik Prevec, Danuta M. Skowronski, Thomas G. Voss, Robert C. Brunham, Martin Petric
Publikováno v:
Journal of General Virology. 87:641-650
Two different severe acute respiratory syndrome (SARS) vaccine strategies were evaluated for their ability to protect against live SARS coronavirus (CoV) challenge in a murine model of infection. A whole killed (inactivated byβ-propiolactone) SARS-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8684f2f43c8e6c3cdc8e3c8dea5acf
https://doi.org/10.1099/vir.0.81579-0
https://doi.org/10.1099/vir.0.81579-0
Publikováno v:
The Journal of Gene Medicine. 8:442-451
Background Helper-dependent (HD) adenovirus (Ad) vectors, deleted of all viral coding sequences, have a higher cloning capacity, improved performance of tissue-specific promoters, and reduced toxicity in animals relative to first-generation Ad vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a043733cb0248b8b48a47afc0ed77fed
https://doi.org/10.1002/jgm.867
https://doi.org/10.1002/jgm.867
Autor:
Michael A. Balamotis, Kohnosuke Mitani, Frank L. Graham, C. Thomas Caskey, Paul Hasty, Arturo Diaz, Atsuhiro Kishimoto, Emi Aizawa, Fumi Ohbayashi
Publikováno v:
Proceedings of the National Academy of Sciences. 102:13628-13633
For gene therapy of inherited diseases, targeted integration/gene repair through homologous recombination (HR) between exogenous and chromosomal DNA would be an ideal strategy to avoid potentially serious problems of random integration such as cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6fb7931b5edf49a65cf332d8a30c482
https://doi.org/10.1073/pnas.0506598102
https://doi.org/10.1073/pnas.0506598102
Autor:
Gunhild Mari Mælandsmo, Carole Evelegh, Robin J. Parks, Robert A. Meulenbroek, Daniel A. Muruve, Frank L. Graham, Marta Pavliv, P. Joel Ross
Publikováno v:
The Journal of Gene Medicine. 7:307-315
Background The development of any vector system as a gene delivery system requires its optimization in vitro and in vivo. Preliminary studies frequently involve the use of a reporter gene, which allows for the rapid and simple assay of vector functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7797443aef25d8765a7fdc472fa24fad
https://doi.org/10.1002/jgm.666
https://doi.org/10.1002/jgm.666
Publikováno v:
Molecular Therapy. 10:758-767
Expression of secretoglobin family 2A member 2 (SCGB2A2, also known as mammaglobin-1) has been detected in a high percentage of primary and metastatic breast tumors, to a lesser extent in normal breast, but not in other normal tissues. Plasmid transf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17cb4df08647ccd1c200d890f07ca6e
https://doi.org/10.1016/j.ymthe.2004.06.849
https://doi.org/10.1016/j.ymthe.2004.06.849